Results 61 to 70 of about 1,712,305 (283)

MITF maintains genome stability in nonmelanocyte lineages

Molecular Oncology, EarlyView.
MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir, Adrián López García de Lomana, Thejus B. Venkatesh, Kritika Kirty, Snaevar Sigurdsson, Linda Vidarsdottir, Ramile Dilshat, Erla Sveinbjornsdottir, Snaedis Ragnarsdottir, Daniel H Magnusson, Maria R. Bustos, Eirikur Steingrimsson, Thorkell Gudjonsson, Stefan Sigurdsson   +13 more
wiley   +1 more source

Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization

Molecular Oncology, EarlyView.
In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu, Nicolas J. Niklaus, Anna M. Schläfli, Igor Tokarchuk, Magali Humbert, Federico La Manna, Bich Vu, David Maul, Ramin Radpour, Marianna Kruithof‐de Julio, Inti Zlobec, Jörn Dengjel, Bruce E. Torbett, Mario P. Tschan   +13 more
wiley   +1 more source

STRUKTUR, KERAGAMAN DAN ASOSIASI KOMUNITAS TUMBUHAN PEMANJAT DENGAN POPULASI ALAM MERBAU DI TAMAN WISATA ALAM GUNUNG MEJA MANOKWARI-PAPUA BARAT (Structure, Diversity and Association of Climbing Plants Communities with Merbau Population in Gunung Meja)

Jurnal Manusia dan Lingkungan, 2016
ABSTRAK Struktur, keragaman dan asosiasi komunitas tumbuhan pemanjat dengan pohon inang di hutan tropis sangat ditentukan oleh banyak faktor biofisik habitat yang saling timbal balik hubungannya.
Elieser Viktor Sirami, Djoko Marsono, Ronggo Sadono, Muhammad Ali Imron   +3 more
doaj   +1 more source

Plant community dynamics in an urban forest fragment of the São Paulo Metropolitan Area, Brazil

Hoehnea, 2020
We present a synthesis (2006-2012) of plant community dynamics in an area (1 ha) of the largest remnant of Atlantic Rain Forest surrounded by São Paulo city.
Hebert Kondrat, Sonia Aragaki, Eduardo Pereira Cabral Gomes   +2 more
doaj   +1 more source

Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer

Molecular Oncology, EarlyView.
Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola, Yasmine Illi, Anna Bircher, Marijn Wilmink, Rachele F. Malagutti, Solenn Ottié, Cordelia Schuler, Pedro A. Ruiz, Cheryl de Vallière, Klaus Seuwen, Gerhard Rogler, Martin Hausmann   +11 more
wiley   +1 more source

Diversity and distribution of climbers of Uttar Pradesh: a preliminary review

Journal of Threatened Taxa
Uttar Pradesh (UP) is one of the largest states in India. Based on vegetation types, the state is divided into four main regions: the Terai Region, Gangetic Plains, Vindhyan, and Semi-arid Regions.
Rameshwar Prasad, Muzeev Ahmad, Sushma Verma, K.M. Prabhukumar, T.S. Rana   +4 more
doaj   +1 more source

A study on diameter-dependent support selection of the tendrils of Cayratia japonica

Scientific Reports, 2022
Organisms make decisions when they perceive cues of varying intensities. In case of climbing plants, the diameter of supports in contact (tree or stem) is an important cue for their growth as plants that coil around a support with large diameter are ...
Kazuya Saito
doaj   +1 more source

Spatial and single‐nuclei transcriptomics reveals idiosyncratic and generic patterns in papillary and anaplastic thyroid cancers

Molecular Oncology, EarlyView.
Matched spatial transcriptomics and single‐nuclei RNA‐seq were generated for anaplastic and BRAFV600E papillary thyroid cancers revealing generic and tumor‐specific states occurring in cancer cells and in the tumor microenvironment. In this context, cancer dedifferentiation mirrored organoid maturation through ordered thyroid marker gain/loss ...
Adrien Tourneur, Joel Rodrigues Vitória, Manuel Saiselet, Ligia Craciun, Denis Larsimont, Anne Lefort, Frédérick Libert, Carine Maenhaut, Sabine Costagliola, Maxime Tarabichi, Mirian Romitti, Vincent Detours   +11 more
wiley   +1 more source

Flora of Ceará state, Brazil Distimake (Convolvulaceae) [PDF]

Rodriguésia
We present a floristic study of Distimake in the state of Ceará, as part of the project “Flora of Ceará: Knowing to conserve”. The study was based on morphological analysis of specimens deposited in herbaria collection or obtained in the field ...
Diego Santos, Luana Mateus de Sousa, Maria Iracema Bezerra Loiola   +2 more
doaj   +1 more source

CEACAM1 participation in breast cancer progression

Molecular Oncology, EarlyView.
In invasive breast cancer (BC), CEACAM1 shifts from an apical to a uniform membranous/cytoplasmic pattern, or is lost, as tumors dedifferentiate, inversely tracking the Ki‐67 proliferative index. In MCF‐7 cells, only CEACAM1‐4L suppresses proliferation, repressing cell cycle and growth factor genes.
Mykola Lyndin, Irina Kube‐Golovin, Anatolii Romaniuk, Gunther Wennemuth   +3 more
wiley   +1 more source