Results 81 to 90 of about 1,712,305 (283)
Molecular Oncology, EarlyView.The kinase SRPK1 directly interacts with the protein TOPBP1 and regulates the pre‐mRNA splicing of WIZ thereby contributing to the activation of the ATR/CHK1 replicative checkpoint in response to replicative stress. This allows cancer cells' genomic stability and survival.
Amani Shreim +17 more
wiley +1 more source
The impact of rock climbing on vascular plants, bryophytes, lichens, and land snails of the Niagara Escarpment, Ontario, Canada [PDF]
, 2000 This thesis addresses the question of whether recreational rock climbing is having a measurable impact on the vascular plants, bryophytes, lichens, and land snails of the Niagara Escarpment in Southern Ontario. Sampling was conducted quantitatively using
McMillan, Michele Ann
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Climbing plants of the Haut-Sassandra forest: species and biomorphology.
, 2005 In the Haut-Sassandra forest in the southwest of Côte d'Ivoire, climbing plants have been inventoried and comprised 30% of the species found. The present study aimed to characterise the climbers of the Haut-Sassandra forests, describing those present ...
D. T. Etien, D. Traoré
core +1 more source
Mutant p53R273H disrupts PDPK1 homodimerization and contributes to PDPK1 activation
Molecular Oncology, EarlyView.How mutant p53R273H drives AKT signaling is unclear. We show that p53R273H, but not wild‐type, directly binds PDPK1 via a mutation‐dependent conformational change. This interaction disrupts inhibitory PDPK1 homodimerization and enhances AKT phosphorylation.
Mei Chee Lim +11 more
wiley +1 more source
Convolvulaceae do Parque Nacional do Catimbau, Pernambuco, Brasil
RodriguésiaConvolvulaceae é constituída por 58 gêneros e ca. 1880 espécies com distribuição cosmopolita, sendo mais frequente nos trópicos. No Brasil é representada por 19 gêneros e aproximadamente 370 espécies.
Geadelande Carolino Delgado Júnior +2 more
doaj +1 more source
, 1903 (Uploaded by Plazi from the Biodiversity Heritage Library) No abstract provided.
openaire +2 more sources
Reprogramming tumor cells with LCOR mRNA nanotherapy to enhance immunotherapy
Molecular Oncology, EarlyView.LCOR (Ligand‐dependent corepressor) mRNA encapsulated in polymeric nanoparticles restores LCOR activity in tumor cells, constraining aggressive tumor cell states and increasing tumor immunogenicity. This reprogramming makes tumor cells more vulnerable to T‐cell attack and enhances their response to immune‐checkpoint immunotherapy.
Gabriel Serra‐Mir +9 more
wiley +1 more source
Spatial heterogeneity of hotspot mutations and clonal relatedness in ovarian endometrioid carcinoma
Molecular Oncology, EarlyView.Spatially resolved analysis revealed heterogeneous distributions of selected cancer‐associated mutations within ovarian endometrioid carcinomas. Shared mutations between paired endometrial and ovarian tumors supported clonal relatedness. These findings highlight the value of sampling multiple tumor regions when interpreting molecular profiles ...
Takahito Ashihara +10 more
wiley +1 more source
Forest climbing plants of West Africa: diversity, ecology and management
, 2005 Climbing plants, including lianas, represent a fascinating component of the ecology of tropical forests. This book focuses on the climbing plants of West African forests.
Parren, M.P.E. +2 more
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HoehneaRESUMO O objetivo do presente estudo é investigar e analisar a diversidade florística de Dioscoreaceae na Reserva Biológica do Alto da Serra de Paranapiacaba para aumentar o conhecimento florístico de Dioscoreales desta unidade de conservação e do Estado
Mizue Kirizawa +2 more
doaj +1 more source