Results 81 to 90 of about 105,706 (296)

Climbing Plants: Attachment and the Ascent for Light [PDF]

Current Biology, 2011
How do vines climb upward and harvest sunlight? A detailed study of one species (Galium aparine L.) shows that leaf hairs (trichomes) provide one solution that solves both tasks simultaneously.
openaire   +2 more sources

Dual PI3K/AKT and CDK4/6 inhibition reveals selective sensitivity in an SHH medulloblastoma stem cell model

Molecular Oncology, EarlyView.
Targeted therapy was evaluated in SHH medulloblastoma using neuroepithelial stem cell (NES) and tumor‐derived NES‐like (tNES) models in 2D monolayers and 3D spheroids. PI3K, AKT, and CDK4/6 inhibitors had minimal effects in NES but markedly reduced viability and growth and induced apoptosis in tNES cells, revealing distinct therapeutic vulnerabilities.
Monika Lukoseviciute, Madeleine Birgersson, Paolo Ceriani, Margareta Wilhelm, Ourania N Kostopoulou   +4 more
wiley   +1 more source

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source

Herbal highs: review on psychoactive effects and neuropharmacology [PDF]

, 2017
Background: A new trend among users of new psychoactive substances’ the consumption of “herbal highs”: plant parts containing psychoactive substances.
Graziano, S, Orsolini, L, Pichini, S., Rotolo, Mc, Schifano, F, Tittarelli, R   +5 more
core   +1 more source

Convolvulaceae do Parque Nacional do Catimbau, Pernambuco, Brasil

Rodriguésia
Convolvulaceae é constituída por 58 gêneros e ca. 1880 espécies com distribuição cosmopolita, sendo mais frequente nos trópicos. No Brasil é representada por 19 gêneros e aproximadamente 370 espécies.
Geadelande Carolino Delgado Júnior, Maria Teresa Buril, Marccus Alves   +2 more
doaj   +1 more source

Deciphering transcriptional plasticity in pancreatic ductal adenocarcinoma reveals alterations in sensory neuron innervation

Molecular Oncology, EarlyView.
Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova, Michele Montrone, Uday Rangaswamy, Francesco Diversi, Irene Schiavo, Denise Ferrarini, Roberta Di Florio, Irene Longo, Michele Coscia, Nicola Zamboni, Giorgia Demontis, Lisa Veghini, Vincenzo Corbo, Remo Sanges, Paul Heppenstall   +14 more
wiley   +1 more source

CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3

Molecular Oncology, EarlyView.
PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh, Nitzan Medina‐Itzhaki, Milena Chekov, Eden Gal‐Swisa, Roba Gabesh‐Wahabi, Inbar Savyon, Inna Naroditsky, Hilary A. Kenny, Basem Fares, Lina Korsensky, Einav Girsh, Liron Berger, Ruth Perets   +12 more
wiley   +1 more source

Flora robotica -- An Architectural System Combining Living Natural Plants and Distributed Robots

, 2017
Key to our project flora robotica is the idea of creating a bio-hybrid system of tightly coupled natural plants and distributed robots to grow architectural artifacts and spaces.
Ayres, Phil, Hamann, Heiko, Heinrich, Mary Katherine, Hofstadler, Daniel Nicolas, Kernbach, Serge, Kuksin, Igor, Nielsen, Stig Anton, Risi, Sebastian, Schmickl, Thomas, Skrzypczak, Tomasz, Soorati, Mohammad Divband, Støy, Kasper, Veenstra, Frank, Wahby, Mostafa, Wojtaszek, Przemyslaw, Zahadat, Payam   +15 more
core  

A livelihoods study of fishers and farmers in Long An Province [PDF]

, 2001
This is the report of a livelihoods study team working together with people from two villages in Long An Province, Vietnam. The study is based on information provided by the villagers, who shared their knowledge and spoke about real problems they face ...

core  

Diversidade florística de Dioscoreaceae na Reserva Biológica do Alto da Serra de Paranapiacaba, Santo André, São Paulo, Brasil

Hoehnea
RESUMO O objetivo do presente estudo é investigar e analisar a diversidade florística de Dioscoreaceae na Reserva Biológica do Alto da Serra de Paranapiacaba para aumentar o conhecimento florístico de Dioscoreales desta unidade de conservação e do Estado
Mizue Kirizawa, Cecilia Carmen Xifreda, Jonathan Henrique da Silva   +2 more
doaj   +1 more source