Results 91 to 100 of about 12,438,664 (296)

Reciprocal control of viral infection and phosphoinositide dynamics

FEBS Letters, EarlyView.
Phosphoinositides, although scarce, regulate key cellular processes, including membrane dynamics and signaling. Viruses exploit these lipids to support their entry, replication, assembly, and egress. The central role of phosphoinositides in infection highlights phosphoinositide metabolism as a promising antiviral target.
Marie Déborah Bancilhon, Bruno Mesmin
wiley   +1 more source

Clinical and epidemiological aspects of yersinioses in Kharkiv region

Annals of Mechnikov's Institute, 2020
Despite great success in diagnostics of infectious diseases and development of new laboratory methods, vast majority of cases are not diagnosed or registered as different diagnosis.
O Mohylenets
doaj  

Real-World Effectiveness of Palbociclib Versus Clinical Trial Results in Patients With Advanced/Metastatic Breast Cancer That Progressed on Previous Endocrine Therapy

, 2019
Objective: The aim of this study was to assess the real-world effectiveness and tolerability of palbociclib combined with endocrine therapy for the treatment of hormone receptor positive (HR-positive), human epidermal growth factor receptor 2 negative ...
Agterof, Mariette J, Bui, Tam Binh V, Afd Pharmacoepi & Clinical Pharmacology, van de Garde, Ewoudt Mw, Pharmacoepidemiology and Clinical Pharmacology, Mariette J Agterof, Ewoudt MW van de Garde, Tam Binh V Bui, Desirée MT Burgers, Burgers, Desirée Mt   +9 more
core   +1 more source

Spatiotemporal and quantitative analyses of phosphoinositides – fluorescent probe—and mass spectrometry‐based approaches

FEBS Letters, EarlyView.
Fluorescent probes allow dynamic visualization of phosphoinositides in living cells (left), whereas mass spectrometry provides high‐sensitivity, isomer‐resolved quantitation (right). Their synergistic use captures complementary aspects of lipid signaling. This review illustrates how these approaches reveal the spatiotemporal regulation and quantitative
Hiroaki Kajiho, Shin Morioka, Junko Sasaki, Takehiko Sasaki   +3 more
wiley   +1 more source

The Role of the Clinical Pharmacist in Hospital Admission Medication Reconciliation in Low-Resource Settings

Pharmacy
Medication discrepancies at hospital admission are common and may lead to adverse outcomes. Medication reconciliation is a critical process for minimizing medication discrepancies and medication errors at the time of hospital admission.
Tijana Kovačević, Sonja Nedinić, Vedrana Barišić, Branislava Miljković, Emir Fazlić, Slobodan Vukadinović, Pedja Kovačević   +6 more
doaj   +1 more source

Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?

FEBS Letters, EarlyView.
This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes, Guilherme M. Azevedo, Amanda P. Barcellos, Diana Bahia   +3 more
wiley   +1 more source

Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation

FEBS Letters, EarlyView.
Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe, Tanmay Kumar Mohanty, Rashna Bhandari, Dorothea Fiedler   +3 more
wiley   +1 more source

Challenges and Opportunities of Internship Method in Technologist Surgery Undergraduate Interns: A Qualitative Content Analysis Study

Iranian Journal of Nursing and Midwifery Research
Background: In the clinical environment, clinical education is one of the components of nursing education that transforms a student from a novice to a competent student. This professional transition can be taught in a variety of methods.
Marzieh Beigom Bigdeli Shamloo, Neda Rashidi, Leila Kalani, Darioush Rokhafrooz   +3 more
doaj   +1 more source

Structural instability impairs function of the UDP‐xylose synthase 1 Ile181Asn variant associated with short‐stature genetic syndrome in humans

FEBS Letters, EarlyView.
The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li, Pedro A. Sánchez‐Murcia, Bernd Nidetzky   +2 more
wiley   +1 more source

IJCM_280A: A prospective study on safety and clinical efficacy of rabies biologicals in paediatric patients with category III animal exposure

Indian Journal of Community Medicine
Background: Rabies remains a significant public health concern worldwide, particularly among paediatric populations who are vulnerable to animal exposures.
Nidhi Fotedar, HS Ravish
doaj   +1 more source