Results 81 to 90 of about 12,438,664 (296)

Experience With Performing Rheocarna Therapy via the Single‐Needle Method for Treatment of Chronic Limb‐Threatening Ischemia

Therapeutic Apheresis and Dialysis, EarlyView.
ABSTRACT Introduction This study investigated the safety and efficacy of single‐needle Rheocarna therapy for chronic limb‐threatening ischemia (CLTI) with wounds. Methods Six patients with CLTI involving ulcers unresponsive to revascularization underwent single‐needle Rheocarna treatment.
Yasutaka Yamauchi, Rie Tanaka, Reona Kawahira, Shingo Nabeta, Kouhei Naoi, Kazuhito Kitajima, Akira Wada, Tomonari Takagi, Norihiko Ohura, Akira Miyamoto   +9 more
wiley   +1 more source

Shifts in hospital-associated pathogens and prevalence trends of carbapenem-resistant Escherichia coli infections, 2021–2023

Journal of Infection in Developing Countries
Introduction: Carbapenem-resistant Escherichia coli (CREC) have emerged as a significant global health threat, particularly in hospital settings, due to their high resistance to critical antibiotics.
Luyao Liu, Shihui Liu, Zhenghai Yang, Fan Wang, Huiwen Yuan, Hao Xu, Jinguan Chen, Xiaoning Li   +7 more
doaj   +1 more source

Prognosis of Long‐Term Continuous Renal Replacement Therapy and the Impact of Combined Continuous Intravenous Sodium Infusion Therapy

Therapeutic Apheresis and Dialysis, EarlyView.
ABSTRACT Introduction Patients requiring long‐term continuous renal replacement therapy (CRRT) generally have poor prognoses. This study evaluated whether adding continuous intravenous sodium infusion (cIVNa) is associated with improved hemodynamics and outcomes in patients undergoing long‐term CRRT for ≥ 7 days.
Akinori Yamaguchi, Atsuyoshi Mita, Kosuke Sonoda, Makoto Harada, Koji Hashimoto, Hiroshi Imamura, Yuji Kamijo   +6 more
wiley   +1 more source

A Deep Learning Model for Predicting ICU Discharge Readiness and Estimating Excess ICU Stay Duration

IEEE Journal of Translational Engineering in Health and Medicine
Objective: In the complex landscape of ICU operations, accurate discharge decisions are crucial yet challenging, as premature discharge risks readmission and mortality while prolonged stays consume resources and heighten infection risk.
Mohsen Nabian, Louis Atallah
doaj   +1 more source

Clinical trial simulations in paediatric oncology: A feasibility study from the Innovative Therapies for Children with Cancer Consortium [PDF]

, 2017
INTRODUCTION: Paediatric dose-finding studies are challenging to perform due to ethical reasons, the limited number of available patients and restricted number of blood samples.
Schellens, Jan H M, Huitema, Alwin D R, Jan H.M. Schellens, Alwin D.R. Huitema, Julie M. Janssen, Zwaan, C. Michel, Afd Pharmacoepi & Clinical Pharmacology, Pharmacoepidemiology and Clinical Pharmacology, C. Michel Zwaan, Janssen, Julie M, Jos H. Beijnen, Beijnen, Jos H, Zwaan, C Michel   +12 more
core   +1 more source

Enteropathogenic E. coli shows delayed attachment and host response in human jejunum organoid‐derived monolayers compared to HeLa cells

FEBS Letters, EarlyView.
Enteropathogenic E. coli (EPEC) infects the human intestinal epithelium, resulting in severe illness and diarrhoea. In this study, we compared the infection of cancer‐derived cell lines with human organoid‐derived models of the small intestine. We observed a delayed in attachment, inflammation and cell death on primary cells, indicating that host ...
Mastura Neyazi, Pilar Samperio Ventayol, Natalie Burkard, Nicolas Schlegel, Carmen Aguilar, Sina Bartfeld   +5 more
wiley   +1 more source

The Myositis Clinical Trials Consortium: an international collaborative initiative to promote clinical trials in adult and juvenile myositis

Idiopathic inflammatory myopathies (IIM), or myositis, are a heterogeneous group of systemic autoimmune disorders that are associated with significant morbidity and mortality.
Lilleker, James B., Rivero-Gallegos, Daphne, Bishnoi, Anuradha, Pais, Faye M., Khoo, Thomas, Lan, Ting-Yuan, Aggarwal, Rohit, Usman, Sabeena Y., Conticini, Edoardo, Bozán, Francisca, Oddis, Chester V., Kavadichanda, Chengappa G., Keret, Shiri, Smaili, Rachid, Tulluru, Gayathri, Leclair, Valérie, Kuwana, Masataka, Sreerama, Reddy Kaushik, Dourado, Eduardo, Gandiga, Prateek C., Tang, Iris Yan Ki, Vencovský, Jiří, Landon-Cardinal, Océane, Dominguez, Solciris A., Yoshida, Akira   +24 more
core   +1 more source

Organoids in pediatric cancer research

FEBS Letters, EarlyView.
Organoid technology has revolutionized cancer research, yet its application in pediatric oncology remains limited. Recent advances have enabled the development of pediatric tumor organoids, offering new insights into disease biology, treatment response, and interactions with the tumor microenvironment.
Carla Ríos Arceo, Jarno Drost
wiley   +1 more source

Effects of Complementary and Alternative Medicines (CAM) on the Metabolism and Transport of Anticancer Drugs

, 2013
The use of complementary and alternative medicines (CAM), such as herbs and dietary supplements, has become more popular among cancer patients. Cancer patients use these supplements for different reasons such as reduction of side effects and improvement ...
Clinical Pharmacology, Mooiman, K.D., Sub Clinical Pharmacology   +2 more
core  

Liquid chromatography-tandem mass spectrometric assay for the quantification of galunisertib in human plasma and the application in a pre-clinical study

, 2019
Galunisertib is an anti-cancer drug currently evaluated in phase I and II clinical trials. This study describes the development and validation of a bioanalytical assay to quantify galunisertib in human plasma using HPLC-MS/MS.
Huijberts, S, Afd Pharmacoepi & Clinical Pharmacology, Schinkel, A H, Pharmacoepidemiology and Clinical Pharmacology, Beijnen, J H, Li, W, Gebretensae, A, Tibben, M M, Rosing, H   +8 more
core   +1 more source