Results 1 to 10 of about 1,320,103 (119)

Morphological and phenotypical characteristics of porcine satellite glial cells of the dorsal root ganglia

open access: yesFrontiers in Neuroanatomy, 2022
Satellite glial cells (SGCs) of the dorsal root ganglia (DRG) ensure homeostasis and proportional excitability of sensory neurons and gained interest in the field of development and maintenance of neuropathic pain.
Isabel Zdora   +8 more
doaj   +1 more source

A Learning Health System Framework to Operationalize Health Data to Improve Quality Care: An Australian Perspective

open access: yesFrontiers in Medicine, 2021
Our healthcare system faces a burgeoning aging population, rising complexity, and escalating costs. Around 10% of healthcare is harmful, and evidence is slow to implement.
Joanne C. Enticott   +12 more
doaj   +1 more source

Bipolar Chronobiology in Men and Mice: A Narrative Review

open access: yesBrain Sciences, 2023
In patients with bipolar disorder, we do not only see a cycling of mood episodes, but also a shift in circadian rhythm. In the present overview, the circadian rhythm, the “internal clock”, and their disruptions are briefly described.
Nadja Freund, Ida Haussleiter
doaj   +1 more source

Review of the Role of the Brain in Chemotherapy-Induced Peripheral Neuropathy

open access: yesFrontiers in Molecular Biosciences, 2021
Chemotherapy-induced peripheral neuropathy (CIPN) is a common, debilitating, and dose-limiting side effect of many chemotherapy regimens yet has limited treatments due to incomplete knowledge of its pathophysiology.
Maryam Omran   +6 more
doaj   +1 more source

The Translational Relevance of Human Circulating Memory Cutaneous Lymphocyte-Associated Antigen Positive T Cells in Inflammatory Skin Disorders

open access: yesFrontiers in Immunology, 2021
Circulating memory T cells are heterogeneous in their tissue tropism. The skin-seeking T cell subset expresses the cutaneous lymphocyte-associated antigen (CLA) on their surface.
Carmen de Jesús-Gil   +7 more
doaj   +1 more source

YI 1.4 Increases in Circulating Trimethylamine-N-Oxide Contribute to the Development of Age-Related Aortic Stiffness in Humans and Mice

open access: yesArtery Research, 2020
Age-related increases in aortic stiffness, assessed by pulse wave velocity (PWV), predict cardiovascular (CV)-related mortality, but the upstream drivers are incompletely understood.
Abigail G Casso   +9 more
doaj   +1 more source

Animal models of chronic pain. Are naturally occurring diseases a potential model for translational research?

open access: yesAustral Journal of Veterinary Sciences, 2021
Despite the vast amount of molecular data obtained from classical pain studies, there is an ongoing translational pain model crisis reflected by the reduced amount of new effective and safe compounds developed to treat chronic pain in humans.
Daniel E. Herzberg, Hedie A. Bustamante
doaj   +1 more source

Evaluating preclinical evidence for clinical translation in childhood brain tumours: Guidelines from the CONNECT, PNOC, and ITCC brain networks

open access: yesFrontiers in Oncology, 2023
Clinical outcomes for many childhood brain tumours remain poor, despite our increasing understanding of the underlying disease biology. Advances in molecular diagnostics have refined our ability to classify tumour types and subtypes, and efforts are ...
Chris Jones   +13 more
doaj   +1 more source

Publisher Correction to: Off label use of Aripiprazole shows promise as a treatment for Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS): a retrospective study of 101 patients treated with a low dose of Aripiprazole

open access: yesJournal of Translational Medicine, 2021
An amendment to this paper has been published and can be accessed via the original article.
Journal of Translational Medicine
doaj   +1 more source

Gene therapy approaches for equine osteoarthritis

open access: yesFrontiers in Veterinary Science, 2022
With an intrinsically low ability for self-repair, articular cartilage injuries often progress to cartilage loss and joint degeneration resulting in osteoarthritis (OA).
Parvathy Thampi   +5 more
doaj   +1 more source

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