Results 11 to 20 of about 1,513,840 (316)

Morphological and phenotypical characteristics of porcine satellite glial cells of the dorsal root ganglia

Frontiers in Neuroanatomy, 2022
Satellite glial cells (SGCs) of the dorsal root ganglia (DRG) ensure homeostasis and proportional excitability of sensory neurons and gained interest in the field of development and maintenance of neuropathic pain.
Isabel Zdora, Isabel Zdora, Lorna Jubran, Lorna Jubran, Lisa Allnoch, Florian Hansmann, Wolfgang Baumgärtner, Wolfgang Baumgärtner, Eva Leitzen   +8 more
doaj   +1 more source

A Learning Health System Framework to Operationalize Health Data to Improve Quality Care: An Australian Perspective

Frontiers in Medicine, 2021
Our healthcare system faces a burgeoning aging population, rising complexity, and escalating costs. Around 10% of healthcare is harmful, and evidence is slow to implement.
Joanne C. Enticott, Joanne C. Enticott, Joanne C. Enticott, Angela Melder, Angela Melder, Alison Johnson, Angela Jones, Tim Shaw, Tim Shaw, Wendy Keech, Jim Buttery, Helena Teede, Helena Teede   +12 more
doaj   +1 more source

Bipolar Chronobiology in Men and Mice: A Narrative Review

Brain Sciences, 2023
In patients with bipolar disorder, we do not only see a cycling of mood episodes, but also a shift in circadian rhythm. In the present overview, the circadian rhythm, the “internal clock”, and their disruptions are briefly described.
Nadja Freund, Ida Haussleiter
doaj   +1 more source

Review of the Role of the Brain in Chemotherapy-Induced Peripheral Neuropathy

Frontiers in Molecular Biosciences, 2021
Chemotherapy-induced peripheral neuropathy (CIPN) is a common, debilitating, and dose-limiting side effect of many chemotherapy regimens yet has limited treatments due to incomplete knowledge of its pathophysiology.
Maryam Omran, Elizabeth K. Belcher, Nimish A. Mohile, Shelli R. Kesler, Michelle C. Janelsins, Andrea G. Hohmann, Ian R. Kleckner   +6 more
doaj   +1 more source

The Translational Relevance of Human Circulating Memory Cutaneous Lymphocyte-Associated Antigen Positive T Cells in Inflammatory Skin Disorders

Frontiers in Immunology, 2021
Circulating memory T cells are heterogeneous in their tissue tropism. The skin-seeking T cell subset expresses the cutaneous lymphocyte-associated antigen (CLA) on their surface.
Carmen de Jesús-Gil, Lídia Sans-de SanNicolàs, Irene García-Jiménez, Marta Ferran, Antonio Celada, Anca Chiriac, Ramon M. Pujol, Luis F. Santamaria-Babí   +7 more
doaj   +1 more source

YI 1.4 Increases in Circulating Trimethylamine-N-Oxide Contribute to the Development of Age-Related Aortic Stiffness in Humans and Mice

Artery Research, 2020
Age-related increases in aortic stiffness, assessed by pulse wave velocity (PWV), predict cardiovascular (CV)-related mortality, but the upstream drivers are incompletely understood.
Abigail G Casso, Rachel A Gioscia-Ryan, Zachary J Sapinsley, Nicholas S VanDongen, Amy E Bazzoni, Andrew P Neilson, Melanie C Zigler, Kevin P Davy, Douglas R Seals, Vienna E Brunt   +9 more
doaj   +1 more source

Animal models of chronic pain. Are naturally occurring diseases a potential model for translational research?

Austral Journal of Veterinary Sciences, 2021
Despite the vast amount of molecular data obtained from classical pain studies, there is an ongoing translational pain model crisis reflected by the reduced amount of new effective and safe compounds developed to treat chronic pain in humans.
Daniel E. Herzberg, Hedie A. Bustamante
doaj   +1 more source

New Journal Launch: Global Clinical and Translational Research

, 2022
We are proud to announce the launch of Global Clinical and Translational Research, a new journal that aims to promote clinical and translational research in the genomic era from a global perspective.
Hughes, Claude, Zhang, Fengyu
core   +1 more source

Evaluating preclinical evidence for clinical translation in childhood brain tumours: Guidelines from the CONNECT, PNOC, and ITCC brain networks

Frontiers in Oncology, 2023
Clinical outcomes for many childhood brain tumours remain poor, despite our increasing understanding of the underlying disease biology. Advances in molecular diagnostics have refined our ability to classify tumour types and subtypes, and efforts are ...
Chris Jones, Karin Straathof, Karin Straathof, Maryam Fouladi, Maryam Fouladi, Darren Hargrave, Darren Hargrave, Michael Prados, Adam Resnick, Francois Doz, David T.W. Jones, David T.W. Jones, Sabine Mueller, Sabine Mueller   +13 more
doaj   +1 more source

Genome-wide analysis of growth phase-dependent translational and transcriptional regulation in halophilic archaea : research article [PDF]

, 2007
Background Differential expression of genes can be regulated on many different levels. Most global studies of gene regulation concentrate on transcript level regulation, and very few global analyses of differential translational efficiencies exist.
Schuster Stephan C, Lange, Christian, Oesterhelt, Dieter, Raddatz, Günter, Dieter Oesterhelt, Soppa, Jörg (Prof. Dr.), Jens Twellmeyer, Christian Lange, Soppa Jörg, Twellmeyer, Jens, Zaigler, Alexander, Oesterhelt Dieter, Jörg Soppa, Günter Raddatz, Lange, C., Raddatz Günter, Zaigler Alexander, Soppa, J., Lange Christian, Schuster, S., Zaigler, A., Schuster, Stephan C., Alexander Zaigler, Oesterhelt, D., Hammelmann Mathias, Raddatz, G., Stephan C Schuster, Mathias Hammelmann, Hammelmann, Mathias, Twellmeyer Jens, Hammelmann, M., Twellmeyer, J.   +31 more
core   +1 more source