Results 91 to 100 of about 1,583,870 (298)

Peptide‐based ligand antagonists block a Vibrio cholerae adhesin

FEBS Letters, EarlyView.
The structure of a peptide‐binding domain of the Vibrio cholerae adhesin FrhA was solved by X‐ray crystallography, revealing how the inhibitory peptide AGYTD binds tightly at its Ca2+‐coordinated pocket. Structure‐guided design incorporating D‐amino acids enhanced binding affinity, providing a foundation for developing anti‐adhesion therapeutics ...
Mingyu Wang, Grace Du, Charity Yongo‐Luwawa, Angelina Lu, Brett Kinrade, Kim Munro, Karl E. Klose, William D. Lubell, Peter Davies, Shuaiqi Guo   +9 more
wiley   +1 more source

Orthopedist involvement in the management of clinical activities: a case study. [PDF]

BMC Health Serv Res, 2021
Côté A, Abasse KS, Laberge M, Gilbert MH, Breton M, Lemaire C.   +5 more
europepmc   +1 more source

Clinically Active Yaws in Sheffield [PDF]

Sexually Transmitted Infections, 1963
J J, DALY, R S, MORTON
openaire   +2 more sources

Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation

FEBS Letters, EarlyView.
Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe, Tanmay Kumar Mohanty, Rashna Bhandari, Dorothea Fiedler   +3 more
wiley   +1 more source

A probiotic Limosilactobacillus fermentum GR-3 mitigates colitis-associated tumorigenesis in mice via modulating gut microbiome

npj Science of Food
Bacterial therapy for colorectal cancer (CRC) represents a burgeoning frontier. The probiotic Limosilactobacillus fermentum GR-3, derived from traditional food “Jiangshui”, exhibited superior antioxidant capacity by producing indole derivatives ICA and ...
Tuoyu Zhou, Jingyuan Wu, Aman Khan, Tianxiang Hu, Yiqing Wang, El-Sayed Salama, Shaochen Su, Huawen Han, Weilin Jin, Xiangkai Li   +9 more
doaj   +1 more source

Impact of COVID-19 Pandemic on the Clinical Activities in Obstetrics and Gynecology: A National Survey in China. [PDF]

Front Med (Lausanne), 2021
Li L, Cao Y, Fan J, Li T, Lang J, Zhang H, Lv J, Zhu L, Chinese Medical Doctor Association.   +8 more
europepmc   +1 more source

Function‐driven design of a surrogate interleukin‐2 receptor ligand

FEBS Letters, EarlyView.
Interleukin (IL)‐2 signaling can be achieved and precisely fine‐tuned through the affinity, distance, and orientation of the heterodimeric receptors with their ligands. We designed a biased IL‐2 surrogate ligand that selectively promotes effector T and natural killer cell activation and differentiation. Interleukin (IL) receptors play a pivotal role in
Ziwei Tang, Zelin Cheng, Teng Li, Fulian Wang, Liangminghui Zhang, Xiuxiu He, Lili Liu, Wei Wang, Aibin Liang, Guang Yang   +9 more
wiley   +1 more source

Sex chromosomes/hormones and the tumor microenvironment of non-reproductive cancers

Frontiers in Immunology
Cancer exhibits profound sexual dimorphism in incidence and therapeutic outcomes, driven by the interplay between biological sex determinants and immune regulation.
Chun-Miao Zhang, Zhong-Bo Ge, Hai-Hong Zhou, Hai-Hong Zhou, Meng-Xiao Wei, Xin-Yuan Ding, Zhe-Zheng Lin, Ming-Yu Wang, Cai-Juan Bai, Cai-Juan Bai   +9 more
doaj   +1 more source

Mechanisms of parasite‐mediated disruption of brain vessels

FEBS Letters, EarlyView.
Parasites can affect the blood vessels of the brain, often causing serious neurological problems. This review explains how different parasites interact with and disrupt these vessels, what this means for brain health, and why these processes matter. Understanding these mechanisms may help us develop better ways to prevent or treat brain infections in ...
Leonor Loira, Sílvia Arroz‐Madeira, Cláudio A. Franco, Sara Silva Pereira   +3 more
wiley   +1 more source

CLINICAL STUDIES ON POLAROGRAPHIC PROTEIN ACTIVITY

Nihon Naika Gakkai Zasshi, 1964
ポーラログラフ蛋白活性による癌判定は他の癌反応よりも陽性率が高く,臨床的に癌反応として用いられている.これを各種疾患に行ない,検討した結果,二,三の疾患の鑑別,並びに診断に役立つことを知ったが,反面において,炎症性疾患などでも陽性を示すものが相当あり,これが本反応の欠点にもなっている.そこで高活性を示す炎症性疾患,悪性腫瘍に治療(手術,放射線治療,制癌剤,抗生剤投与)を行ない,経時的に観察することにより,両疾患の活性変動態度の異なることを見出し,これを応用し両疾患の鑑別を行なうに良き結果をえた.また,これと共に,両疾患の治療効果判定,予後推測にも,経時的に本反応を行なうことが良い指針を与えることを知つに.
openaire   +3 more sources