Results 111 to 120 of about 1,583,870 (298)

PICALM::MLLT10 translocated leukemia

FEBS Letters, EarlyView.
This comprehensive review of PICALM::MLLT10 translocated acute leukemia provides an in‐depth review of the structure and function of CALM, AF10, and the fusion oncoprotein (1). The multifaceted molecular mechanisms of oncogenesis, including nucleocytoplasmic shuttling (2), epigenetic modifications (3), and disruption of endocytosis (4), are then ...
John M. Cullen, Antonia C. Nakatsugawa, Natalie Barton, Henry Haines, Gary S. Stein, Janet L. Stein, Daniel S. Wechsler, Jessica L. Heath   +7 more
wiley   +1 more source

'Low-value' clinical care in general practice: associations of low value care in GP trainees' practice, including formative and summative examination performance - protocol for cross-sectional and retrospective cohort study analyses using the QUestionable In Training Clinical Activities (QUIT-CA) index. [PDF]

BMJ Open, 2022
Magin P, Ralston A, Tapley A, Holliday E, Ball J, van Driel ML, Davey A, Klein L, FitzGerald K, Spike N, Fielding A.   +10 more
europepmc   +1 more source

ANG1005, a novel peptide-paclitaxel conjugate crosses the BBB and shows activity in patients with recurrent CNS metastasis from breast cancer, results from a phase II clinical study [PDF]

, 2016
Shou‐Ching Tang, Priya Kumthekar, Andrew Brenner, Santosh Kesari, David Piccioni, CK Anders, J.A. Carillo, Pavani Chalasani, Peter Kabos, Shannon L. Puhalla, Agustin A. García, Katherine H. R. Tkaczuk, Manmeet S. Ahluwalia, Nehal J. Lakhani, Nuhad K. Ibrahim   +14 more
openalex   +1 more source

Comparison of the Immediate Effect of Active Stretching Techniques and Self-myofascial Release on the Flexibility of the Iliotibial Band and Functional Activities in Semi-Elite Athletes: A Randomized Clinical Trial [PDF]

, 2023
Ehsan Afshari, Mehrnaz Kajbafvala, Holakoo Mohsenifar, Leila Abbasi   +3 more
openalex   +1 more source

Cell wall target fragment discovery using a low‐cost, minimal fragment library

FEBS Letters, EarlyView.
LoCoFrag100 is a fragment library made up of 100 different compounds. Similarity between the fragments is minimized and 10 different fragments are mixed into a single cocktail, which is soaked to protein crystals. These crystals are analysed by X‐ray crystallography, revealing the binding modes of the bound fragment ligands.
Kaizhou Yan, Mathew Stanley, Olawale Raimi, Andrew T. Ferenbach, Helge C Dorfmueller, Daan M. F. van Aalten   +5 more
wiley   +1 more source

Monitoring brain activity in preterms: mathematics helps to predict clinical outcome: Figure 1 [PDF]

, 2015
Heiko J. Luhmann, Nora de Camp, Jürgen Bergeler   +2 more
openalex   +1 more source

Supplementary tables. Novel protein markers of androgen activity in humans with potential clinical value.

, 2021
Aleksander Giwercman, K. Barbara Sahlin, Indira Plá, Krzysztof Pawłowski, Yvonne Lundberg Giwercman, Irene Leijonhufvud, Roger Appelqvist, Aniel Sánchez, Johan Malm   +8 more
openalex   +1 more source

Inhibiting stearoyl‐CoA desaturase suppresses bone metastatic prostate cancer by modulating cellular stress, mTOR signaling, and DNA damage response

FEBS Letters, EarlyView.
Bone metastasis in prostate cancer (PCa) patients is a clinical hurdle due to the poor understanding of the supportive bone microenvironment. Here, we identify stearoyl‐CoA desaturase (SCD) as a tumor‐promoting enzyme and potential therapeutic target in bone metastatic PCa.
Alexis Wilson, Mackenzie K Herroon, Shane Mecca, Laimar C Garmo, Jacob Lindquist, Shrila Rajendran, Steve M. Patrick, Izabela Podgorski   +7 more
wiley   +1 more source

SPACO+: a mixed methods protocol to assessing the effectiveness of an educative intervention in patients with Long Covid

BMC Infectious Diseases
Background The management of many chronic diseases requires a multidisciplinary and holistic approach. Long Covid is a recent, poorly understood disease with several symptoms. Most recommendations suggest a multidisciplinary approach.
Odette Linda Kamdem, Caroline Dupre, Valdez Heugno, Amandine Baudot, Estelle Essangui, Marie Blanquet, Nina Guercon, Marie Fanget, Sasha Bayet, Marie Pierre Vericel, Pauline Oustric, Yves Mbama Biloa , Elie Shikitele Lola, Mabrouk Nekaa, Mario Debellis, François Stierlam, Ronelle Fabiola Mbia, Olivier Tatsilong, Peguy Assomo Ndemba, Williams Bell Ngan, Valérie Ndobo, Clarisse Ayina Ayina, Jerson Mekoulou, Marie Solange Ndom Ebongue, Thomas Celarier, Louise Ruiz, Veronique Regnier, Claude Bika, Françoise Ngo Sack, Judith Laure Ngondi, Nathalie Barth, Samuel Honore Mandengue, Frederic Roche, Elisabeth Botelho-nevers, Carole Else Eboumbou Moukoko, Céline Nguefeu Nkenfou, David Hupin, Bienvenu Bongue, Jessica Guyot   +38 more
doaj   +1 more source

Structural biology of ferritin nanocages

FEBS Letters, EarlyView.
Ferritin is a conserved iron‐storage protein that sequesters iron as a ferric mineral core within a nanocage, protecting cells from oxidative damage and maintaining iron homeostasis. This review discusses ferritin biology, structure, and function, and highlights recent cryo‐EM studies revealing mechanisms of ferritinophagy, cellular iron uptake, and ...
Eloise Mastrangelo, Flavio Di Pisa
wiley   +1 more source