Results 151 to 160 of about 18,646,845 (356)

In Vitro Activity of Doxycycline Against Bacteria from Clinical Material [PDF]

, 1967
Henry D. Isenberg
openalex   +1 more source

TRPM4 contributes to cell death in prostate cancer tumor spheroids, and to extravasation and metastasis in a zebrafish xenograft model system

Molecular Oncology, EarlyView.
Transient receptor potential melastatin‐4 (TRPM4) is overexpressed in prostate cancer (PCa). Knockout of TRPM4 resulted in reduced PCa tumor spheroid size and decreased PCa tumor spheroid outgrowth. In addition, lack of TRPM4 increased cell death in PCa tumor spheroids.
Florian Bochen, Saurav Subedi, Federico La Manna, Sofia Jarrin, Irida Papapostolou, Marianna Kruithof‐de Julio, Christine Peinelt   +6 more
wiley   +1 more source

Cystatin A promotes the antitumor activity of T helper type 1 cells and dendritic cells in murine models of pancreatic cancer

Molecular Oncology, EarlyView.
Pancreatic ductal adenocarcinoma (PDAC) is a disease with very poor prognosis due to therapeutic limitations. We investigated the antitumor effects of cystatin A (CSTA) in PDAC murine models. We are first to confirm that CSTA enhances T helper type 1‐mediated antitumor effects through promotion of dendritic cells and M1 macrophage activity. CSTA can be
Alessandro Nasti, Shingo Inagaki, Tuyen Thuy Bich Ho, Akihiro Seki, Keiko Yoshida, Kosuke Satomura, Yoshio Sakai, Shuichi Kaneko, Taro Yamashita   +8 more
wiley   +1 more source

Phytochemistry, pharmacology and clinical applications of the traditional Chinese herb Pseudobulbus Cremastrae seu Pleiones (Shancigu): A review

Arabian Journal of Chemistry, 2022
Pseudobulbus Cremastrae seu Pleiones (PCsP) is a traditional Chinese herbal medicine known as “Shancigu” in China. It has the property of relieving fever, counteracting toxicity, dissipating phlegm and resolving masses.
Sai Jiang, Mengyun Wang, Salman Zafar, Lin Jiang, Jiangyi Luo, Huimin Zhao, Siying Tian, Yuqing Zhu, Caiyun Peng, Wei Wang   +9 more
doaj  

CLINICAL STUDIES ON POLAROGRAPHIC PROTEIN ACTIVITY

Nihon Naika Gakkai Zasshi, 1964
ポーラログラフ蛋白活性による癌判定は他の癌反応よりも陽性率が高く,臨床的に癌反応として用いられている.これを各種疾患に行ない,検討した結果,二,三の疾患の鑑別,並びに診断に役立つことを知ったが,反面において,炎症性疾患などでも陽性を示すものが相当あり,これが本反応の欠点にもなっている.そこで高活性を示す炎症性疾患,悪性腫瘍に治療(手術,放射線治療,制癌剤,抗生剤投与)を行ない,経時的に観察することにより,両疾患の活性変動態度の異なることを見出し,これを応用し両疾患の鑑別を行なうに良き結果をえた.また,これと共に,両疾患の治療効果判定,予後推測にも,経時的に本反応を行なうことが良い指針を与えることを知つに.
openaire   +4 more sources

Integration of single‐cell and bulk RNA‐sequencing data reveals the prognostic potential of epithelial gene markers for prostate cancer

Molecular Oncology, EarlyView.
Prostate cancer is a leading malignancy with significant clinical heterogeneity in men. An 11‐gene signature derived from dysregulated epithelial cell markers effectively predicted biochemical recurrence‐free survival in patients who underwent radical surgery or radiotherapy.
Zhuofan Mou, Lorna W. Harries
wiley   +1 more source

A seven week observational analysis of clinical activities in a North Italian orthopaedic hospital during the second wave of SARS-CoV-2 pandemic: far from usual volumes, but different from the first wave. [PDF]

Int Orthop, 2021
Zagra L, Faraldi M, Andreata M, Ottaiano I, Basile G, Lombardi G.   +5 more
europepmc   +1 more source

Fibrinolytic activity in the clinical crisis of sickle-cell anaemia. [PDF]

, 1967
Altaf Mahmood, D.M. Macintosh, A. G. Shaper   +2 more
openalex   +1 more source

Clinical significance of stratifying prostate cancer patients through specific circulating genes

Molecular Oncology, EarlyView.
We tested a specific panel of genes representative of luminal, neuroendocrine and stem‐like cells in the blood of prostate cancer patients, showing predictive value from diagnosis to late stages of disease. This approach allows monitoring of treatment responses and outcomes at specific time points in trajectories.
Seta Derderian, Edouard Jarry, Arynne Santos, Quentin Vesval, Lucie Hamel, Rafael Sanchez‐Salas, Alexis Rompré‐Brodeur, Wassim Kassouf, Raghu Rajan, Fadi Brimo, Marie Duclos, Armen Aprikian, Simone Chevalier   +12 more
wiley   +1 more source

MET variants with activating N‐lobe mutations identified in hereditary papillary renal cell carcinomas still require ligand stimulation

Molecular Oncology, EarlyView.
MET variants in the N‐lobe of the kinase domain, found in hereditary papillary renal cell carcinoma, require ligand stimulation to promote cell transformation, in contrast to other RTK variants. This suggests that HGF expression in the microenvironment is important for tumor growth in such patients. Their sensitivity to MET inhibitors opens the way for
Célia Guérin, Audrey Vinchent, Marie Fernandes, Isabelle Damour, Agathe Laratte, Rémi Tellier, Gabriella O. Estevam, Jean‐Pascal Meneboo, Céline Villenet, Clotilde Descarpentries, James S. Fraser, Martin Figeac, Alexis B. Cortot, Etienne Rouleau, David Tulasne   +14 more
wiley   +1 more source