Results 201 to 210 of about 18,646,845 (356)

Highly multiplexed digital PCR assay for simultaneous quantification of variant allele frequencies and copy number alterations of KRAS and GNAS in pancreatic cancer precursors

Molecular Oncology, EarlyView.
Combining melting curve analysis enhances the multiplexing capability of digital PCR. Here, we developed a 14‐plex assay to simultaneously measure single nucleotide mutations and amplifications of KRAS and GNAS, which are common driver genes in pancreatic cancer precursors. This assay accurately quantified variant allele frequencies in clinical samples
Junko Tanaka, Tatsuo Nakagawa, Yusuke Ono, Yoshio Kamura, Takeshi Ishida, Hidemasa Kawabata, Kenji Takahashi, Hiroki Sato, Andrew S. Liss, Yusuke Mizukami, Takahide Yokoi   +10 more
wiley   +1 more source

D3S-001, a KRAS G12C Inhibitor with Rapid Target Engagement Kinetics, Overcomes Nucleotide Cycling, and Demonstrates Robust Preclinical and Clinical Activities. [PDF]

Cancer Discov
Zhang J, Lim SM, Yu MR, Chen C, Wang J, Wang W, Rui H, Lu J, Lu S, Mok T, Chen ZJ, Cho BC.   +11 more
europepmc   +1 more source

Clinical Significance of Serum Transaminase Activities

, 1964
Ichiro Ujihira
openalex   +2 more sources

Exploration of heterogeneity and recurrence signatures in hepatocellular carcinoma

Molecular Oncology, EarlyView.
This study leveraged public datasets and integrative bioinformatic analysis to dissect malignant cell heterogeneity between relapsed and primary HCC, focusing on intercellular communication, differentiation status, metabolic activity, and transcriptomic profiles.
Wen‐Jing Wu, Jianchao Wang, Fuqing Chen, Xuefeng Wang, Bin Lan, Ruyi Fu, Hong Wen, Fangfang Chen, Wei Hong, Tian‐Yu Tang, Ying He, Gang Chen, Jianyin Zhou, Hai‐Long Piao, Di Chen, Shu‐Yong Lin   +15 more
wiley   +1 more source

Mixed probiotics modulated gut microbiota to improve spermatogenesis in bisphenol A-exposed male mice

Ecotoxicology and Environmental Safety
Bisphenol A (BPA), an environmental endocrine disruptor (EDC), has been implicated in impairing intestinal and male reproductive dysfunction. The efficacy of gut microbiota modulation for BPA-exposed testicular dysfunction has yet to be verified through ...
Jingyuan Wu, Tuoyu Zhou, Haofei Shen, Yanbiao Jiang, Qi Yang, Shaochen Su, Luming Wu, Xue Fan, Min Gao, Yang Wu, Yun Cheng, Yuan Qi, Ting Lei, Yongan Xin, Shiqiang Han, Xiangkai Li, Yiqing Wang   +16 more
doaj  

Role of 2-day critical ultrasound training curriculum in guiding clinical activities in China. [PDF]

Am J Transl Res
Xin D, Lian H, Zhao H, Zeng X, Li L, Huo Y, Chen M, Chao Y, Wang X, He W.   +9 more
europepmc   +1 more source

Doubling Pharmacist Coverage in the Intensive Care Unit: Impact on the Pharmacists' Clinical Activities and Team Members' Satisfaction. [PDF]

Hosp Pharm, 2017
McDaniel J, Bass L, Pate T, DeValve M, Miller S.   +4 more
europepmc   +1 more source

Assessment of activity in SLE: a clinical and serological study.

, 1975
Jason Edmonds, C Bruneau, G R Hughes
openalex   +1 more source

Documenting the Clinical Pharmacist's Activities: Back to Basics [PDF]

, 1988
Linda M. Strand, Robert J. Cipolle, Peter C. Morley   +2 more
openalex   +1 more source

The atypical KRASQ22K mutation directs TGF‐β response towards partial epithelial‐to‐mesenchymal transition in patient‐derived colorectal cancer tumoroids

Molecular Oncology, EarlyView.
TGF‐β has a complex role in cancer, exhibiting both tumor‐suppressive and tumor‐promoting properties. Using a series of differentiated tumoroids, derived from different stages and mutational background of colorectal cancer patients, we replicate this duality of TGF‐β in vitro. Notably, the atypical but highly aggressive KRASQ22K mutation rendered early‐
Theresia Mair, Philip König, Milena Mijović, Jessica Kalla, Anil Baskan, Loan Tran, Kristina Draganić, Pedro Morata Saldaña, Carlos Uziel Pérez Malla, Janette Pfneissl, Andreas Tiefenbacher, Julijan Kabiljo, Velina S. Atanasova, Lisa Wozelka‐Oltjan, Leonhard Müllauer, Michael Bergmann, Raheleh Sheibani‐Tezerji, Gerda Egger   +17 more
wiley   +1 more source