Targeting p38α in cancer: challenges, opportunities, and emerging strategies
p38α normally regulates cellular stress responses and homeostasis and suppresses malignant transformation. In cancer, however, p38α is co‐opted to drive context‐dependent proliferation and dissemination. p38α also supports key functions in cells of the tumor microenvironment, including fibroblasts, myeloid cells, and T lymphocytes.
Angel R. Nebreda
wiley +1 more source
Converting an Entire Course Into a Game by Implementing Gated Pathways. [PDF]
Sharmin N, Chow AK.
europepmc +1 more source
Correlation of the differential expression of PIK3R1 and its spliced variant, p55α, in pan‐cancer
PIK3R1 undergoes alternative splicing to generate the isoforms, p85α and p55α. By combining large patient datasets with laboratory experiments, we show that PIK3R1 spliced variants shape cancer behavior. While tumors lose the protective p85α isoform, p55α is overexpressed, changes linked to poorer survival and more pronounced in African American ...
Ishita Gupta +10 more
wiley +1 more source
Clinical and functional outcomes of arthroscopic autologous collagen-induced chondrogenesis (ACIC) for osteochondral lesions of the talus: A retrospective case series. [PDF]
Gatti SD +4 more
europepmc +1 more source
Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley +1 more source
Satisfaction and perceptions with clinical practicum course among graduating nursing students: a mixed methods study. [PDF]
Wu CJ, Tsai LH, Chen CM, Chiang SF.
europepmc +1 more source
Assessing the carbon footprint of French academic clinical trials using the NIHR method. [PDF]
Auriault C +4 more
europepmc +1 more source
Factors Associated With Patient Safety Activities of Clinical Nurses: A Cross-Sectional Secondary Data Analysis. [PDF]
Lee J, Nam KH, Suh Y, Lee Y, Lee D.
europepmc +1 more source
Starting Up Clinical Trials in Emergency Medicine: Advice and Acronyms for New Investigators. [PDF]
Southerland LT +6 more
europepmc +1 more source
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Journal of the American Academy of Dermatology, 2017Current modalities of understanding disease state (active/stable) are limited when considering treatment of vitiligo.We sought to develop a rapid, accurate, and noninvasive assessment of vitiligo state.In daylight and Wood's light examinations, 2 common clinical types of vitiligo were identified as amelanotic with sharply demarcated borders and ...
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