Results 271 to 280 of about 1,583,870 (298)
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Oxaliplatin clinical activity: a review
Critical Reviews in Oncology/Hematology, 2000Oxaliplatin (Eloxatin), a recently developed third-generation cisplatin analogue with a 1,2-diaminocyclohexane (DACH) carrier ligand, has displayed preclinical and clinical activity in a wide variety of tumour types. Synergistic with 5-FU in colorectal cancer (CRC), the combination has proven efficacy in 5-FU-resistant advanced disease and in ...
Misset, Jean Louis +4 more
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Implementing Active Clinical Training Approach (ACTA) in clinical practice
Nurse Education in Practice, 2020Active Clinical Training Approach (ACTA) is a newly developed theoretical model of active learning to promote self-directed learning through integrating the process, person, and context model. This study aimed to assess whether the use of Active Clinical Training Approach (ACTA) increases students' engagement in clinical practicum and enhances self ...
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1998
Development of new antiviral drugs is needed and challenging. Antiviral drug discovery has focused on viral inhibition strategies principally directed at viral penetration and uncoating or viral genome replication, and the era of human immunodeficiency virus (HIV) infection and acquired immunodeficiency syndrome (AIDS) has helped regenerate interest in
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Development of new antiviral drugs is needed and challenging. Antiviral drug discovery has focused on viral inhibition strategies principally directed at viral penetration and uncoating or viral genome replication, and the era of human immunodeficiency virus (HIV) infection and acquired immunodeficiency syndrome (AIDS) has helped regenerate interest in
openaire +1 more source
Drotrecogin alfa (activated): diffusion from clinical trials to clinical practice
European Journal of Anaesthesiology, 2008Although the PROWESS trial demonstrated a mortality benefit, subsequent studies in different patient populations have not reproduced the effect. As a result, concerns have been expressed about the clinical effectiveness of drotrecogin alfa (activated).
S, Ridley +6 more
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Clinical disease activity in systemic vasculitis
Current Opinion in Rheumatology, 1996Long-term follow-up data indicate that the systemic vasculitides are chronic relapsing diseases with high morbidity. It is therefore of paramount importance to distinguish activity, which requires cytotoxic or immunosuppressive therapy, from damage requiring rehabilitation.
A R, Exley, P A, Bacon
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Active-Controlled Clinical Trials
2012In order to fulfill the requirement of a new drug application, a sponsor needs to conduct randomized clinical trials to demonstrate that the test treatment is effective. With placebo control in the clinical trial, efficacy of the test treatment is demonstrated by showing that the test treatment is statistically and clinically superior to placebo ...
Yi Tsong, Joanne Zhang
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Clinical dental anatomy active learning
Journal of Dental Education, 2023Norio Kitagawa +2 more
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Physical activity and depression: clinical experience
Acta Psychiatrica Scandinavica, 1994Two quasiexperimental and 10 experimental exercise intervention studies have been performed in depressed subjects. Some of the studies have methodological shortcomings, but in all studies the results point in the same direction: aerobic exercise is more effective than no treatment, but not significantly different from other forms of therapy, including ...
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Clinical Pharmacology of Active Variceal Bleeding
Digestive Diseases, 1992Although the mechanism initiating and maintaining variceal hemorrhage is not completely understood, there has been general agreement in recent years on the concept that variceal rupture occurs when the tension on the wall of the varices reaches a critical value (the rupture point) that leads to the leakage of the elastic components of the wall. If this
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