Results 181 to 190 of about 874,306 (301)

Midline and Mediolateral Episiotomy: Risk Assessment Based on Clinical Anatomy. [PDF]

Diagnostics (Basel), 2021
Garner DK, Patel AB, Hung J, Castro M, Segev TG, Plochocki JH, Hall MI.   +6 more
europepmc   +1 more source

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source

Clinical Anatomy and Diagnostic Challenges in Peripheral Nerve Trauma for the Forensic Physician. [PDF]

Diagnostics (Basel)
Hostiuc S, Ciobanu OM, Popa E, Căținaș R, Ionescu-Mihăiță AM, Sima A, Negoi I, Costescu M.   +7 more
europepmc   +1 more source

Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer

Molecular Oncology, EarlyView.
Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni, Antonella Palmese, Stefano Scalera, Laura Cipriani, Davide Mascolo, Patrizia Vici, Teresa Arcuri, Lorena Filomeno, Eriseld Krasniqi, Giovanni Blandino, Giulia Bon, Marcello Maugeri‐Saccà   +11 more
wiley   +1 more source

Submental Intubation: Clinical Anatomy and Video Technical Note. [PDF]

Head Neck
Rohée-Traoré A, Gagnieur P, Gleizal A, Daurade M.   +3 more
europepmc   +1 more source

Musculocutaneous and median nerve branching: anatomical variations. Case Series from UR clinical anatomy and literature review. [PDF]

Afr Health Sci, 2022
Kubwimana O, Ndata A, Ivang A, Ndahimana P, Nzayisenga A, Byiringiro JC, Gashegu J.   +6 more
europepmc   +1 more source

CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3

Molecular Oncology, EarlyView.
PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh, Nitzan Medina‐Itzhaki, Milena Chekov, Eden Gal‐Swisa, Roba Gabesh‐Wahabi, Inbar Savyon, Inna Naroditsky, Hilary A. Kenny, Basem Fares, Lina Korsensky, Einav Girsh, Liron Berger, Ruth Perets   +12 more
wiley   +1 more source

Assessing LLM-generated vs. expert-created clinical anatomy MCQs: a student perception-based comparative study in medical education. [PDF]

Med Educ Online
Elzayyat M, Mohammad JN, Zaqout S.
europepmc   +1 more source

E2A selectively regulates TGF‐β–induced apoptosis in KRAS‐mutant non‐small cell lung cancer

Molecular Oncology, EarlyView.
Ability to induce apoptosis by TGF‐β is frequently lost in advanced lung adenocarcinoma despite intact TGF‐β signaling. We identify E2A as a mutant KRAS–dependent mediator of resistance to TGF‐β–induced apoptosis. TGF‐β induces E2A via SMAD3 in mutant KRAS cells, and E2A silencing restores apoptosis and enhances radiation response in cell lines ...
Sergei Chuikov, Shiva Krishna Katkam, Zhefan Wang, Venkateshwar G. Keshamouni   +3 more
wiley   +1 more source

A novel program of cadaver surgical training for young surgeons at the Clinical Anatomy Laboratory Nagoya (CALNA). [PDF]

Gen Thorac Cardiovasc Surg
Nakamura S, Ueno H, Imamura Y, Okado S, Nomata Y, Takenaka H, Watanabe H, Kawasumi Y, Kadomatsu Y, Kato T, Mizuno T, Chen-Yoshikawa TF.   +11 more
europepmc   +1 more source