Results 191 to 200 of about 10,946,773 (345)

Clinical Anatomy and Ultrasound Bootcamp for Anesthesiology Residents: A Pilot Study and Lessons Learned. [PDF]

J Educ Perioper Med
Menon A, Asri R, Grachan JJ, Eloy JD, Holan G.   +4 more
europepmc   +1 more source

Use of Advanced Artificial Intelligence in Forensic Medicine, Forensic Anthropology and Clinical Anatomy. [PDF]

Healthcare (Basel), 2021
Thurzo A, Kosnáčová HS, Kurilová V, Kosmeľ S, Beňuš R, Moravanský N, Kováč P, Kuracinová KM, Palkovič M, Varga I.   +9 more
europepmc   +1 more source

Developmental programmes drive cellular plasticity, disease progression and therapy resistance in lung adenocarcinoma

Molecular Oncology, EarlyView.
This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska, Stephany Gallardo, Nur S. Zainal, Leena Arora, Matthew Ellis, Maria‐Antoinette Lopez, Judith Austine, Sai Pittla, Serena J Chee, Aiman Alzetani, Emily C Shaw, Christian H Ottensmeier, Gareth J Thomas, Christopher J Hanley   +13 more
wiley   +1 more source

Midline and Mediolateral Episiotomy: Risk Assessment Based on Clinical Anatomy. [PDF]

Diagnostics (Basel), 2021
Garner DK, Patel AB, Hung J, Castro M, Segev TG, Plochocki JH, Hall MI.   +6 more
europepmc   +1 more source

Stimulator of interferon genes agonist augmented antitumor immunity of osimertinib in Egfr‐mutated lung cancer

Molecular Oncology, EarlyView.
Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura, Tadahiro Kuribayashi, Johannes Brägelmann, Sachi Okawa, Masataka Taoka, Shunta Mori, Tomoka Nishimura, Takaaki Tanaka, Go Makimoto, Kiichiro Ninomiya, Kammei Rai, Eiki Ichihara, Ryohei Katayama, Katsuyuki Hotta, Masahiro Tabata, Yosuke Togashi, Yoshinobu Maeda, Martin L. Sos, Katsuyuki Kiura, Kadoaki Ohashi   +19 more
wiley   +1 more source

Clinical Anatomy and Diagnostic Challenges in Peripheral Nerve Trauma for the Forensic Physician. [PDF]

Diagnostics (Basel)
Hostiuc S, Ciobanu OM, Ciobanu OM, Popa E, Căținaș R, Ionescu-Mihăiță AM, Sima A, Negoi I, Costescu M.   +8 more
europepmc   +1 more source

Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining

Molecular Oncology, EarlyView.
IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis, Jack V. Mills, Wojciech Niedzwiedz, Valentine M. Macaulay   +3 more
wiley   +1 more source

Submental Intubation: Clinical Anatomy and Video Technical Note. [PDF]

Head Neck
Rohée-Traoré A, Gagnieur P, Gleizal A, Daurade M.   +3 more
europepmc   +1 more source

Musculocutaneous and median nerve branching: anatomical variations. Case Series from UR clinical anatomy and literature review. [PDF]

Afr Health Sci, 2022
Kubwimana O, Ndata A, Ivang A, Ndahimana P, Nzayisenga A, Byiringiro JC, Gashegu J.   +6 more
europepmc   +1 more source

Finding novel vulnerabilities of hypomorphic BRCA1 alleles

Molecular Oncology, EarlyView.
Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder, Klaas de Lint, Hồ Mỹ Phúc Võ, Mariana M. Góis, Rosalie A. Kampen, Marta San Martin Alonso, Ilse Nootenboom, Veronica Garzero, Tiemen J. Wendel, Rob M. F. Wolthuis, Sylvie M. Noordermeer   +10 more
wiley   +1 more source