Results 111 to 120 of about 11,652,301 (264)

Design and analysis strategies for robust microbiome ageing research

FEBS Letters, EarlyView.
The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik, İsmail Güderer, Yi Wang, Tayyaba Alvi, Prasoon Pandey, Handan Melike Dönertaş   +5 more
wiley   +1 more source

The Clinical Applications of Triiodothyronine [PDF]

BMJ, 1957
A W, GOOLDEN, C D, BURRELL
openaire   +2 more sources

Reconstructing enzyme evolution by protein engineering

FEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler, Markus R. Busch, Reinhard Sterner   +2 more
wiley   +1 more source

Clinical Psychology Today Vol 4 Issue 1 (Summer 2020)

, 2020
'Clinical Psychology Today' a journal for Clinical Psychologists to share research, practice and exchange views on the science and practice of Clinical Psychology.
White, Lynn, Collins, Padraig
core  

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

FEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta, Hari Baskar Balasubramanian, Amir Pasokh, Marietta Zille   +3 more
wiley   +1 more source

An epithelial GPR35 isoform supports tumor‐associated transcriptional and metabolic phenotypes

FEBS Letters, EarlyView.
GPR35 generates two functionally distinct isoforms with previously unresolved roles. GPR35‐short mediates immune‐cell chemotaxis, while GPR35‐long is enriched in colorectal cancer epithelium, where it supports increased metabolism, proliferation, and tumor‐associated transcriptional programs.
Jørgen D. Rønneberg, Martine Hjeltnes, Josephine Krieger, Joshua E. Elias, Maria Stensland, Kristian Holm, Xiaojun Jiang, Chuki Khangsar, Tuula A. Nyman, Arthur Kaser, Johannes R. Hov, Tom H. Karlsen, Nicole C. Kaneider, Frode L. Jahnsen, Georg Schneditz   +14 more
wiley   +1 more source

The dual role of FSP1 in programmed cell death: resisting ferroptosis in the cell membrane and promoting necroptosis in the nucleus of THP-1 cells

Molecular Medicine
Background Acute monocytic leukemia-M5 (AML-M5) remains a challenging disease due to its high morbidity and poor prognosis. In addition to the evidence mentioned earlier, several studies have shown that programmed cell death (PCD) serves a critical ...
Xiaoqian Tan, Yinling He, Panpan Yu, Yunong Deng, Zhongcheng Xie, Jiami Guo, Qin Hou, Pin Li, Xiaoyan Lin, Siyu Ouyang, Wentao Ma, Yushu Xie, Zilong Guo, Dandan Chen, Zhixia Zhang, Yunyu Zhu, Fei Huang, Ziye Zhao, Cen Zhang, Zhirong Guo, Xi Chen, Tianhong Peng, Liang Li, Wei Xie   +23 more
doaj   +1 more source

Efficacy of dietary supplements as an adjunctive therapy for polycystic ovary syndrome: an umbrella meta-analysis

Frontiers in Nutrition
IntroductionPolycystic ovary syndrome (PCOS) affects 5–15% of reproductive-aged women and involves significant metabolic dysregulation, for which nutritional interventions show therapeutic potential.
Rutong Wang, Kongwei Huang, Mengyao Wang, Wenhui Zou, Yujun Huang, Wei Jiang, Yingqi Feng, Huilong Shen, Xiaocan Lei   +8 more
doaj   +1 more source

National early warning score National Clinical Guideline No. 1 Summary

, 2013
The National Early Warning Score and COMPASS© Education programme project is a work stream of the National Acute Medicine Programme, HSE, in association with the National Critical Care Programme, HSE, the National Elective Surgery Programme, HSE, the ...
National Clinical Effectiveness Committee
core  

Structure‐forward targeting of claudins with synthetic binders

FEBS Letters, EarlyView.
Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley   +1 more source