Results 41 to 50 of about 11,652,301 (264)

Early Body Mass Index z‐Score Change and Resolution of Severe Malnutrition in Children With Sickle Cell Anemia in a Low‐Income Setting: A Prospective Single‐Arm Extension Study

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Children with sickle cell anemia (SCA) in low‐income settings are at risk of severe malnutrition, but optimal nutritional management has not been established. We evaluated an intensified ready‐to‐use therapeutic food (RUTF) regimen in children with persistent severe malnutrition after initial treatment and assessed whether early ...
Safiya Gambo, Shehu Umar Abdullahi, Hassan Adam Murtala, Halima Kabir, Khadija A. Shamsu, Sari A. Acra, Virginia A. Stallings, Mark Rodeghier, Michael R. DeBaun, Lauren J. Klein   +9 more
wiley   +1 more source

Clinical applications of amrinone

Journal of Cardiothoracic Anesthesia, 1989
A bipyridine derivative, amrinone is a noncatecholamine, nonglycoside alternative in the treatment of perioperative myocardial dysfunction. A type-3 phosphodiesterase enzyme inhibitor, amrinone combines positive inotropic support with systemic and pulmonary vasodilation.
openaire   +2 more sources

Early clinical development of targeted anticancer agents [PDF]

, 2017
Van Brummelen studied the safety and preliminary signs of efficacy of several novel targeted anticancer agents in phase I trials. In her thesis, she reports the results of trials with the immunotherapies pembrolizumab and cergutuzumab-amunaleukin, and ...
van Brummelen, E.M.J., Pharmacoepidemiology and Clinical Pharmacology, Sub Clinical Pharmacology   +2 more
core  

Pharmaceutical development of an amorphous solid dispersion formulation of elacridar hydrochloride for proof-of-concept clinical studies [PDF]

, 2017
Objective: A novel tablet formulation containing an amorphous solid dispersion (ASD) of elacridar hydrochloride was developed with the purpose to resolve the drug’s low solubility in water and to conduct proof-of-concept clinical studies.
Schellens, J. H M, Nuijen, B., Afd Pharmacoepi & Clinical Pharmacology, Pharmacoepidemiology and Clinical Pharmacology, Beijnen, J. H., Sawicki, E.   +5 more
core   +2 more sources

Social Functioning Within the First Years After Pediatric Brain Tumor Diagnosis and the Relationship With Family Psychosocial Risk

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Survivors of pediatric brain tumors (PBTs) can experience long‐term social difficulties, impacting quality of life. Beyond medical and environmental factors, family psychosocial risk may play a role in social outcomes by shaping the caregiving environment and may provide intervention options.
Renske H. Houben, Marisa H. Huisman, Martha A. Grootenhuis, Femke K. Aarsen, Marita Partanen   +4 more
wiley   +1 more source

BMP-9 mediates fibroproliferation in fibrodysplasia ossificans progressiva through TGF-β signaling

EMBO Molecular Medicine
Fibrodysplasia ossificans progressiva (FOP) is a rare genetic disorder presenting with progressive heterotopic ossification (HO) in soft tissues. Early-stage FOP is characterized by recurrent episodes of painful tissue swelling (flare-ups), with numerous
Chengzhu Zhao, Yoshiko Inada, Souta Motoike, Daisuke Kamiya, Kyosuke Hino, Makoto Ikeya   +5 more
doaj   +1 more source

Clinical applications for estetrol [PDF]

The Journal of Steroid Biochemistry and Molecular Biology, 2009
In this paper the potential clinical applications for the human fetal estrogen estetrol (E(4)) are presented based on recently obtained data in preclinical and clinical studies. In the past E(4) has been classified as a weak estrogen due to its rather low estrogen receptor affinity.
Monique, Visser, Herjan J T, Coelingh Bennink   +1 more
openaire   +2 more sources

Retrospective Analysis of Donor Lymphocyte Infusions in Pediatric Patients With Mixed Chimerism After Hematopoietic Stem Cell Transplantation

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Allogeneic hematopoietic stem cell transplantation (alloHSCT) is an essential therapy for several malignant and nonmalignant diseases, but relapse and graft loss remain the principal threats to its success. Routine monitoring of chimerism and minimal residual disease (MRD) enables early detection of imminent recurrence and guides ...
Carmen Junk, Sebastian Michaelis, Michaela Döring, Thomas Eichholz, Ursula Holzer, Martin Ebinger, Tim Flaadt, Rupert Handgretinger, Peter Lang, Jan Frederic Weller, Markus Mezger   +10 more
wiley   +1 more source

Defective flow space limits the scaling up of turbulence bioreactors for platelet generation

Communications Engineering
To complement donor-dependent platelets supplies, we previously developed an ex vivo manufacturing system using induced pluripotent stem cell (iPSC)-derived expandable immortalized megakaryocyte progenitor cell lines (imMKCLs), and a turbulent flow ...
Haruki Okamoto, Kosuke Fujio, Sou Nakamura, Yasuo Harada, Hideki Hayashi, Natsumi Higashi, Atsushi Ninomiya, Ryota Tanaka, Naoshi Sugimoto, Naoya Takayama, Atsushi Kaneda, Akira Sawaguchi, Yoshikazu Kato, Koji Eto   +13 more
doaj   +1 more source

Blood Levels to Optimize Antipsychotic Treatment in Clinical Practice: A Joint Consensus Statement of the American Society of Clinical Psychopharmacology and the Therapeutic Drug Monitoring Task Force of the Arbeitsgemeinschaft für Neuropsychopharmakologie und Pharmakopsychiatrie.

, 2020
The quantification of antipsychotic levels in blood, also known as therapeutic drug monitoring (TDM), is a potentially useful tool of modern personalized therapy that can be applied to augment antipsychotic use and dosing decisions.
Newcomer, J.W., Citrome, L., Goff, D.C., Kane, J.M., Correll, C.U., Gründer, G., Robinson, D.G., Zernig, G., Haen, E., Piacentino, D., Hiemke, C., Schoretsanitis, G., Paulzen, M., Conca, A., Baumann, P., Freudenreich, O., Pharmakopsychiatrie, TTDMTFOTAFNU, Kelly, D.L., Marder, S.R.   +18 more
core   +1 more source