Results 21 to 30 of about 11,652,301 (264)

iPSC-Derived Platelets Depleted of HLA Class I Are Inert to Anti-HLA Class I and Natural Killer Cell Immunity

Stem Cell Reports, 2020
Summary: The ex vivo production of platelets depleted of human leukocyte antigen class I (HLA-I) could serve as a universal measure to overcome platelet transfusion refractoriness caused by HLA-I incompatibility.
Daisuke Suzuki, Charlotte Flahou, Norihide Yoshikawa, Ieva Stirblyte, Yoshikazu Hayashi, Akira Sawaguchi, Marina Akasaka, Sou Nakamura, Natsumi Higashi, Huaigeng Xu, Takuya Matsumoto, Kosuke Fujio, Markus G. Manz, Akitsu Hotta, Hitoshi Takizawa, Koji Eto, Naoshi Sugimoto   +16 more
doaj   +1 more source

Clinical pharmacokinetics of an amorphous solid dispersion tablet of elacridar [PDF]

, 2017
Elacridar is an inhibitor of the permeability glycoprotein (P-gp) and the breast cancer resistance protein (BCRP) and is a promising absorption enhancer of drugs that are substrates of these drug-efflux transporters.
Schellens, Jan H M, Huitema, Alwin D R, Verheijen, Remy B., van Tellingen, Olaf, Afd Pharmacoepi & Clinical Pharmacology, Pharmacoepidemiology and Clinical Pharmacology, Sawicki, Emilia, Beijnen, Jos H., Nuijen, Bastiaan, Steeghs, Neeltje   +9 more
core   +2 more sources

Enhanced Axonal Extension of Subcortical Projection Neurons Isolated from Murine Embryonic Cortex using Neuropilin-1

Frontiers in Cellular Neuroscience, 2017
The cerebral cortical tissue of murine embryo and pluripotent stem cell (PSC)-derived neurons can survive in the brain and extend axons to the spinal cord.
Jun Takahashi, Jun Takahashi, Noritaka Sano, Noritaka Sano, Takafumi Shimogawa, Takafumi Shimogawa, Hideya Sakaguchi, Yoshihiko Ioroi, Yoshihiko Ioroi, Yoshifumi Miyawaki, Asuka Morizane, Susumu Miyamoto   +11 more
doaj   +1 more source

Betaine attenuate chronic restraint stress-induced changes in testicular damage and oxidative stress in male mice

Reproductive Biology and Endocrinology, 2022
Scope Male fertility and sperm quality are negatively affected by psychological stress. Chronic restraint stress (CRS) is a common psychological stress that has a negative effect on sperm. Betaine (BET), an active ingredient isolated from Lycium barbarum,
Xingqi Meng, Lixuan Peng, Jie Xu, Dongming Guo, Wenyu Cao, Yang Xu, Suyun Li   +6 more
doaj   +1 more source

A disease-specific iPS cell resource for studying rare and intractable diseases

Inflammation and Regeneration, 2023
Background Disease-specific induced pluripotent stem cells (iPSCs) are useful tools for pathological analysis and diagnosis of rare diseases. Given the limited available resources, banking such disease-derived iPSCs and promoting their widespread use ...
Megumu K. Saito, Mitsujiro Osawa, Nao Tsuchida, Kotaro Shiraishi, Akira Niwa, Knut Woltjen, Isao Asaka, Katsuhisa Ogata, Suminobu Ito, Shuzo Kobayashi, Shinya Yamanaka   +10 more
doaj   +1 more source

A review of clinical decision-making: Models and current research [PDF]

, 2007
Aims and objectives: The aim of this paper was to review the current literature with respect to clinical decision-making models and the educational application of models to clinical practice.
Banning, M, Maggi Banning
core   +1 more source

Single-cell RNA-seq reveals heterogeneity in hiPSC-derived muscle progenitors and E2F family as a key regulator of proliferation

Life Science Alliance, 2022
This study identified and characterized four different populations of muscle progenitor cells derived from human induced pluripotent stem cells. Human pluripotent stem cell-derived muscle progenitor cells (hiPSC-MuPCs) resemble fetal-stage muscle ...
Minas Nalbandian, Mingming Zhao, Hiroki Kato, Tatsuya Jonouchi, May Nakajima-Koyama, Takuya Yamamoto, Hidetoshi Sakurai   +6 more
doaj   +1 more source

Clinical applications of microRNAs [PDF]

F1000Research, 2013
MicroRNAs represent a class of small RNAs derived from polymerase II controlled transcriptional regions. The primary transcript forms one or several bulging double stranded hairpins which are processed by Drosha and Dicer into hetero-duplexes. The targeting microRNA strand of the duplex is incorporated into the RNA Induced Silencing Complex from where ...
Hydbring, Per, Badalian-Very, Gayane
openaire   +4 more sources

Clinical application of Adlloy-OH in conservative and prosthetic dentistry [PDF]

, 1992
P(論文)Adlloy-OH was developed as a surface modification material for precious metal adherend. Excellent adhesion of dental adhesive materials to precious metal alloys is realized by the simple application of Adlloy-OH.
23329, 大野, 弘機, 松田, 浩一, 坂口, 邦彦, 23330, 23331, 23332, 23333, 原口, 克博, 日景, 盛   +9 more
core  

Medication Use and Clinical Outcomes by the Dutch Institute for Clinical Auditing Medicines Program: Quantitative Analysis [PDF]

, 2022
BACKGROUND: The Dutch Institute for Clinical Auditing (DICA) Medicines Program was set up in September 2018 to evaluate expensive medicine use in daily practice in terms of real-world effectiveness using only existing data sources.
van Breeschoten, Jesper, Hilarius, Doranne, Pasmooij, Anna Maria Gerdina, van Loosen, Caspar, van Dartel, Maaike, de Boer, Anthonius, Wouters, Michel, Afd Pharmacoepi & Clinical Pharmacology, Pharmacoepidemiology and Clinical Pharmacology, Ismail, Rawa Kamaran, van der Flier, Silvia, van den Eertwegh, Alfons   +11 more
core   +2 more sources