Results 11 to 20 of about 11,652,301 (264)
L1CAM Is a Marker for Enriching Corticospinal Motor Neurons in the Developing Brain
Frontiers in Cellular Neuroscience, 2020 The cerebral cortical tissue of murine embryo and pluripotent stem cell-derived neurons can survive in the adult brain and extend axons to the spinal cord.
Bumpei Samata +6 more
doaj +1 more source
Ex vivo generation of platelet products from human iPS cells
Inflammation and Regeneration, 2020 Platelet products are used in treatments for thrombocytopenia caused by hematopoietic diseases, chemotherapy, massive hemorrhages, extracorporeal circulation, and others. Their manufacturing depends on volunteers who donate blood. However, it is becoming
Sou Nakamura, Naoshi Sugimoto, Koji Eto
doaj +1 more source
Nature Communications, 2021 Tendon self-renewal occurs rarely and reconstructive surgery comes with significant limitations. Here the authors present an induced pluripotent stem cell-based method to generate tenocytes, analyze their developmental trajectory using scRNA-seq, and ...
Taiki Nakajima +8 more
doaj +1 more source
Stem Cells Translational Medicine, 2021 Nakajo‐Nishimura syndrome (NNS) is an autoinflammatory disorder caused by a homozygous mutations in the PSMB8 gene. The administration of systemic corticosteroids is partially effective, but continuous treatment causes severe side effects.
Naoya Kase +8 more
doaj +1 more source
SMN promotes mitochondrial metabolic maturation during myogenesis by regulating the MYOD-miRNA axis
Life Science Alliance, 2023 SMN contributes to muscle maturation by binding to the promoter regions of MYOD1 and miRNAs and regulating the expression of these molecules during myogenesis.
Akihiro Ikenaka +6 more
doaj +1 more source
Regenerative Therapy, 2022 Background: – Neural tissue grafting is an acceptable form of cell therapy for brain injury and diseases. However, methods that can evaluate the graft integration and measure axonal extensions in a 3D environment are limited in scale, inconvenient, and ...
Luc Grinand, Jun Takahashi
doaj +1 more source
Clinical Pharmacokinetics of Systemically Administered Antileishmanial Drugs [PDF]
, 2017 This review describes the pharmacokinetic properties of the systemically administered antileishmanial drugs pentavalent antimony, paromomycin, pentamidine, miltefosine and amphotericin B (AMB), including their absorption, distribution, metabolism and ...
Schellens, Jan H M +17 more
core +1 more source
Reproductive Biology and Endocrinology, 2022 Diabetes mellitus (DM), a high incidence metabolic disease, is related to the impairment of male spermatogenic function. Spermidine (SPM), one of the biogenic amines, was identified from human seminal plasma and believed to have multiple pharmacological ...
Jin-Yuan Wang +11 more
doaj +1 more source
Frontiers in Physiology, 2023 Duchenne muscular dystrophy (DMD) is an X-linked fatal muscular disease, affecting one in 3,500 live male births worldwide. Currently, there is no cure for this disease, except for steroid-based treatment to attenuate disease progression.
Masae Sato +3 more
doaj +1 more source
Considerations in hiPSC-derived cartilage for articular cartilage repair
Inflammation and Regeneration, 2018 Background A lack of cell or tissue sources hampers regenerative medicine for articular cartilage damage. Main text We review and discuss the possible use of pluripotent stem cells as a new source for future clinical use.
Akihiro Yamashita +5 more
doaj +1 more source