Results 111 to 120 of about 9,840,923 (344)

PICALM::MLLT10 translocated leukemia

FEBS Letters, EarlyView.
This comprehensive review of PICALM::MLLT10 translocated acute leukemia provides an in‐depth review of the structure and function of CALM, AF10, and the fusion oncoprotein (1). The multifaceted molecular mechanisms of oncogenesis, including nucleocytoplasmic shuttling (2), epigenetic modifications (3), and disruption of endocytosis (4), are then ...
John M. Cullen, Antonia C. Nakatsugawa, Natalie Barton, Henry Haines, Gary S. Stein, Janet L. Stein, Daniel S. Wechsler, Jessica L. Heath   +7 more
wiley   +1 more source

Cell wall target fragment discovery using a low‐cost, minimal fragment library

FEBS Letters, EarlyView.
LoCoFrag100 is a fragment library made up of 100 different compounds. Similarity between the fragments is minimized and 10 different fragments are mixed into a single cocktail, which is soaked to protein crystals. These crystals are analysed by X‐ray crystallography, revealing the binding modes of the bound fragment ligands.
Kaizhou Yan, Mathew Stanley, Olawale Raimi, Andrew T. Ferenbach, Helge C Dorfmueller, Daan M. F. van Aalten   +5 more
wiley   +1 more source

PERFIL HEMATOLÓGICO E BIOQUÍMICO DE OVINOS SUPLEMENTADOS COM SALINOMICINA SUBMETIDOS À ACIDOSE LÁCTICA RUMINAL

Ciência Animal Brasileira, 2012
Twelve sheep were distributed into two groups, control (CG) and salinomycin (SG), to study clinical, hematological and biochemical alterations in sheep supplemented with the ionophore and to evaluate its effect in preventing experimental lactic ruminal ...
Aerlem Cynnara Vieira, Adaucides Câmara Câmara, Carla Lopes Mendonça, José Augusto Bastos Afonso   +3 more
doaj  

Effect of anti-retroviral therapy on oxidative stress in hospitalized HIV-infected adults with and without TB. [PDF]

, 2018
BackgroundHIV infection and opportunistic infections cause oxidative stress (OS), which is associated with tissue damage. Anti-retroviral therapy (ART) is used to treat HIV and decrease the risk of opportunistic infections, but it is unclear whether ART ...
Andama, Alfred, Bukenya, Andrew, Byanyima, Patrick, Davis, J Lucian, Huang, Laurence, Kaswabuli, Sylvia, Matovu, Denis Kasozi, Mayanja-Kizza, Harriet, Musisi, Emmanuel, Sanyu, Ingvar, Seremba, Emmanuel, Sessolo, Abdul, Walter, Nicholas D, Worodria, William, Zawedde, Josephine   +14 more
core   +3 more sources

Comprehensive Experiment—Clinical Biochemistry: Determination of Blood Glucose and Triglycerides in Normal and Diabetic Rats

Biochemistry and Molecular Biology Education, 2014
For second year medical students, we redesigned an original laboratory experiment and developed a combined research‐teaching clinical biochemistry experiment. Using an established diabetic rat model to detect blood glucose and triglycerides, the students
Li Jiao, Xiujuan Shi, Wang Juan, Jia Song, Xu Lei, Guotong Xu, L. Lixia   +6 more
semanticscholar   +1 more source

Inhibiting stearoyl‐CoA desaturase suppresses bone metastatic prostate cancer by modulating cellular stress, mTOR signaling, and DNA damage response

FEBS Letters, EarlyView.
Bone metastasis in prostate cancer (PCa) patients is a clinical hurdle due to the poor understanding of the supportive bone microenvironment. Here, we identify stearoyl‐CoA desaturase (SCD) as a tumor‐promoting enzyme and potential therapeutic target in bone metastatic PCa.
Alexis Wilson, Mackenzie K Herroon, Shane Mecca, Laimar C Garmo, Jacob Lindquist, Shrila Rajendran, Steve M. Patrick, Izabela Podgorski   +7 more
wiley   +1 more source

Medical Biochemistry as subdiscipline of laboratory medicine in Serbia [PDF]

Journal of Medical Biochemistry, 2017
Medical biochemistry is the usual name for clinical biochemistry or clinical chemistry in Serbia, and medical biochemist is the official name for the clinical chemist (or clinical biochemist). This is the largest sub-discipline of the laboratory medicine
Jovičić Snežana, Majkić-Singh Nada, Majkić-Singh Nada   +2 more
doaj  

Історія лабораторії біохімії Національного наукового центру «Інститут експериментальної і клінічної ветеринарної медицини» [PDF]

, 2011
В даній статті показана історія лабораторії біохімії Національного наукового центру «Інститут експериментальної і клінічної ветеринарної медицини» - першого науково-дослідного інституту України в області ветеринарної медицини.In given article history of
Корольов, А. Г.
core  

The human Cranio Facial Development Protein 1 (Cfdp1) gene encodes a protein required for the maintenance of higher-order chromatin organization [PDF]

, 2017
The human Cranio Facial Development Protein 1 (Cfdp1) gene maps to chromosome 16q22.2-q22.3 and encodes the CFDP1 protein, which belongs to the evolutionarily conserved Bucentaur (BCNT) family.
Atterrato, Maria Teresa, Dimitri, Patrizio, Losada, Ana, Messina, Giovanni, Piacentini, Lucia, Prozzillo, Yuri   +5 more
core   +3 more sources

β‐TrCP overexpression enhances cisplatin sensitivity by depleting BRCA1

Molecular Oncology, EarlyView.
Low levels of β‐TrCP (Panel A) allow the accumulation of BRCA1 and CtIP, which facilitate the repair of cisplatin‐induced DNA damage via homologous recombination (HR) and promote tumor cell survival. In contrast, high β‐TrCP expression (Panel B) leads to BRCA1 and CtIP degradation, impairing HR repair, resulting in persistent DNA damage and apoptosis ...
Rocío Jiménez‐Guerrero, Alejandro Belmonte‐Fernández, Mónica González‐Moreno, Laura Rodríguez‐Cordero, Begoña Pérez‐Valderrama, Joaquín Herrero‐Ruíz, Francisco Romero, Carmen Sáez, Miguel Á. Japón   +8 more
wiley   +1 more source