Results 131 to 140 of about 9,840,923 (344)

Bridging the gap: Multi‐stakeholder perspectives of molecular diagnostics in oncology

Molecular Oncology, EarlyView.
Although molecular diagnostics is transforming cancer care, implementing novel technologies remains challenging. This study identifies unmet needs and technology requirements through a two‐step stakeholder involvement. Liquid biopsies for monitoring applications and predictive biomarker testing emerge as key unmet needs. Technology requirements vary by
Jorine Arnouts, Senada Koljenović, Elise Daems, Karolien De Wael, Marc Peeters, Léon C. van Kempen, Greetje Vanhoutte, Karen Zwaenepoel, Timon Vandamme   +8 more
wiley   +1 more source

Clinical and Laboratory Barriers to the Timely Diagnosis of Sulphite Oxidase Deficiency

Proceedings of Singapore Healthcare, 2010
Isolated sulphite oxidase deficiency (SOD) is a rare genetic neurometabolic disorder characterised by intractable seizures and progressive severe neurological dysfunction.
Chew Thye Choong MBBS, MMED (Paed), Claire Hart MSc Clinical Biochemistry, FRCPath, Ee Shien Tan MBBS, MMED (Paed), Denise Li Meng Goh MBBS, MMED (Paed)   +3 more
doaj   +1 more source

Adenosine‐to‐inosine editing of miR‐200b‐3p is associated with the progression of high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
A‐to‐I editing of miRNAs, particularly miR‐200b‐3p, contributes to HGSOC progression by enhancing cancer cell proliferation, migration and 3D growth. The edited form is linked to poorer patient survival and the identification of novel molecular targets.
Magdalena Niemira, Anna Skwarska, Karolina Chwialkowska, Agnieszka Ostrowska, Gabriela Sokolowska, Anna Zeller, Anna Erol, Andrzej Eljaszewicz, Bartosz Hanczaruk, Anna Michalska‐Falkowska, Agnieszka Tarasik, Joanna Reszec‐Gielazyn, Pawel Knapp, Marcin Moniuszko, Adam Kretowski   +14 more
wiley   +1 more source

Molecular differences between young and mature stria vascularis from organotypic explants and transcriptomics

iScience
Summary: The stria vascularis (SV) is an essential component of the inner ear that regulates the ionic environment required for hearing. SV degeneration disrupts cochlear homeostasis, leading to irreversible hearing loss, yet a comprehensive ...
Matsya Ruppari Thulasiram, Ryosuke Yamamoto, Rafal T. Olszewski, Shoujun Gu, Robert J. Morell, Michael Hoa, Alain Dabdoub   +6 more
doaj   +1 more source

Investigating the cell of origin and novel molecular targets in Merkel cell carcinoma: a historic misnomer

Molecular Oncology, EarlyView.
This study indicates that Merkel cell carcinoma (MCC) does not originate from Merkel cells, and identifies gene, protein & cellular expression of immune‐linked and neuroendocrine markers in primary and metastatic Merkel cell carcinoma (MCC) tumor samples, linked to Merkel cell polyomavirus (MCPyV) status, with enrichment of B‐cell and other immune cell
Richie Jeremian, Sriraam Sivachandran, Melissa Galati, Brandon Ramchatesingh, Hibo Rijal, Johnny Hanna, Elena Netchiporouk, May Chergui, Margaret Redpath, Samy Abou Setah, Ivan V. Litvinov   +10 more
wiley   +1 more source

Recommendation of the Czech Nephrological Society and Czech Society of Clinical Biochemistry ČLS JEP for Examination of Proteinuria [PDF]

, 2011
Fyziologie, J Brinkman, S Bakker, R Gansevoort, W Comper, O Jerums, T Osicka, W Comper, T Osicka, M Engli, D Fliser, J Novak, V Thongboonkerd, B Friedeck, W Guder, W Hofmann, W Hofmann, B Rossmller, W Guder, H Ibsen, M Olsen, K Wachtell, M Ivandic, W Hofmann, W Guder, B Julian, H Suzuki, Y Suzuki, K/ Doqi, W Keane, G Eknoyan, Proteinuria, T Kouri, G Fogazzi, V Gant, E Lamb, F Mackenzie, P Stevens, M Mcqueen, H Gerstein, J Pogue, G Miller, D Bruns, G Hortin, N Ohisa, K Kanemitsu, R Matsuki, J Redon, R Rodby, R Rohde, Z Sharon, L Russo, W Comper, T Osicka, A Shaikh, J Segmiller, T Borland, V Teplan, V Tesa, L Vojtov, T Zima, L Thomas, V Thongboonkerd, K Mcleish, J Arthur, J Klein, D Wilson, R Anderson, J abka, O Viklick, S Dusilov-Sulkov, Autorsk Kolektiv ; Tesa, Zima Vladimr, Racek Tom, Teplan Jaroslav, Friedeck Vladimr, Kratochvla Bedich, Grantov Josef, Kubek Jana, Zdenek Doc, Mudr, Csc Romana Ryav   +81 more
openalex   +1 more source

Integrated genomic and proteomic profiling reveals insights into chemoradiation resistance in cervical cancer

Molecular Oncology, EarlyView.
A comprehensive genomic and proteomic analysis of cervical cancer revealed STK11 and STX3 as a potential biomarkers of chemoradiation resistance. Our study demonstrated EGFR as a therapeutic target, paving the way for precision strategies to overcome treatment failure and the DNA repair pathway as a critical mechanism of resistance.
Janani Sambath, Irene A. George, Srikanth S. Manda, Prasanth Ariyannur, Ekta R. Dhawale, Raja Sekhar Kommu, Rajan Datar, Darshana Patil, Vinita Trivedi, Manisha Singh, Kumar Prabhash, Sewanti Limaye, Richa Chauhan, Prashant Kumar   +13 more
wiley   +1 more source

The Evaluation of the Quality Performance of Biochemical Analytes in Clinical Biochemistry Laboratory Using Six Sigma Matrices. [PDF]

Cureus, 2023
Panda CR, Kumari S, Mangaraj M, Nayak S.
europepmc   +1 more source

The Evergreen Connection of Clinical and Medical Biochemistry [PDF]

, 2020
Ramon Cacabelo
openalex   +1 more source

YAP1::TFE3 mediates endothelial‐to‐mesenchymal plasticity in epithelioid hemangioendothelioma

Molecular Oncology, EarlyView.
The YAP1::TFE3 fusion protein drives endothelial‐to‐mesenchymal transition (EndMT) plasticity, resulting in the loss of endothelial characteristics and gain of mesenchymal‐like properties, including resistance to anoikis, increased migratory capacity, and loss of contact growth inhibition in endothelial cells.
Ant Murphy, Samuel Hartzler, Paula A. Vargas Carranza, Shyaman Jayasundara, Madison E. Yates, Nimod D. Janson, Bozhi Liu, Annaleigh Benton, Majid Kazemian, Jason A. Hanna   +9 more
wiley   +1 more source