Results 161 to 170 of about 413,875 (287)

Targeted protein degradation in oncology: novel therapeutic opportunity for solid tumours?

Molecular Oncology, EarlyView.
Current anticancer therapies are limited by the occurrence of resistance and undruggability of most proteins. Targeted protein degraders are novel, promising agents that trigger the selective degradation of previously undruggable proteins through the recruitment of the ubiquitin–proteasome machinery. Their mechanism of action raises exciting challenges,
Noé Herbel, Sophie Postel‐Vinay
wiley   +1 more source

Digitisers: their use in the entry of orders, urinalysis results, and isoenzyme interpretation in a clinical biochemistry computer system. [PDF]

, 1984
Jane F Loughlin, J F Tuckerman, A R Henderson   +2 more
openalex   +1 more source

Aberrant expression of nuclear prothymosin α contributes to epithelial‐mesenchymal transition in lung cancer

Molecular Oncology, EarlyView.
Nuclear prothymosin α inhibits epithelial‐mesenchymal transition (EMT) in lung cancer by increasing Smad7 acetylation and competing with Smad2 for binding to SNAI1, TWIST1, and ZEB1 promoters. In early‐stage cancer, ProT suppresses TGF‐β‐induced EMT, while its loss in the nucleus in late‐stage cancer leads to enhanced EMT and poor prognosis.
Liyun Chen, Chung‐Teng Wang, Jia‐Ming Chang, Ai‐Li Shiau, Gia‐Shing Shieh, Yau‐Lin Tseng, Yi‐Ting Yen, Tang‐Hsiu Huang, Li‐Hsin Cheng, Yu‐Chih Wu, Chao‐Liang Wu, Bing‐Hua Su, Pensee Wu   +12 more
wiley   +1 more source

Cross-Sectional Associations between Clinical Biochemistry and Nutritional Biomarkers and Sarcopenic Indices of Skeletal Muscle in the Baltimore Longitudinal Study of Aging. [PDF]

J Nutr
Scott J, Yates M, Tanaka T, Ferrucci L, Cameron D, Welch AA.   +5 more
europepmc   +1 more source

Prognostic Value of a Clinical Biochemistry-Based Nomogram for Coronavirus Disease 2019. [PDF]

Front Med (Lausanne), 2020
Yu J, Nie L, Wu D, Chen J, Yang Z, Zhang L, Li D, Zhou X.   +7 more
europepmc   +1 more source

Clinical Biochemistry Services for Liver Transplantation

, 1975
J. G. Lines
openalex   +1 more source

Progress in Clinical Biochemistry and Medicine [PDF]

, 1990
Andrew Green
openalex   +1 more source

Determination of ADP/ATP translocase isoform ratios in malignancy and cellular senescence

Molecular Oncology, EarlyView.
The individual functions of three isoforms exchanging ADP and ATP (ADP/ATP translocases; ANTs) on the mitochondrial membrane remain unclear. We developed a method for quantitatively differentiating highly similar human ANT1, ANT2, and ANT3 using parallel reaction monitoring. This method allowed us to assess changes in translocase levels during cellular
Zuzana Liblova, Dominika Maurencova, Barbora Salovska, Marek Kratky, Tomas Mracek, Zuzana Korandova, Alena Pecinova, Pavla Vasicova, David Rysanek, Ladislav Andera, Ivo Fabrik, Rudolf Kupcik, Pavel Kashmel, Pinky Sultana, Vojtech Tambor, Jiri Bartek, Josef Novak, Marie Vajrychova, Zdenek Hodny   +18 more
wiley   +1 more source

Achieving High Standards in Clinical Biochemistry: Integrating Six Sigma, Quality Goal Index (QGI), and Operating Specifications (OPSpecs) for Targeted Quality Enhancement. [PDF]

Cureus
Panchal KR, Vaghasiya ND, Vasava SH, Patel DS.   +3 more
europepmc   +1 more source

Analysis of short-term variation and long-term drift during reagent kit lot change in an NABL accredited clinical biochemistry laboratory. [PDF]

J Med Biochem, 2021
Ambade V, Misra P, Vashum Y, Sharma M, Mukherjee B, Bhatia K, Puliyath M, Rasu P, Indra PB, Sibin MK.   +9 more
europepmc   +1 more source