Results 131 to 140 of about 41,126 (213)

Gamma Knife treatment planning using knowledge‐based reinforcement learning

open access: yesMedical Physics, Volume 53, Issue 7, July 2026.
Abstract Background Inverse planning is often used for Gamma Knife radiosurgery, allowing clinicians to mathematically specify desired clinical objectives and dose limits. The objectives are controlled by weights that are manually tuned to find the desired trade‐off, which varies from case to case.
Christopher Huynh   +5 more
wiley   +1 more source

Long-Read HiFi Genome Sequencing Resolves Retrotransposon-Mediated Deletions in TANGO2 Deficiency Disorder. [PDF]

open access: yesNeurol Genet
Sabbagh Q   +8 more
europepmc   +1 more source

Getting It Right the Second Time: How Can we Optimize First‐Generation Cephalosporin Dosing for Skin and Soft Tissue Infections in the 21st Century?

open access: yesPharmacotherapy: The Journal of Human Pharmacology and Drug Therapy, Volume 46, Issue 7, July 2026.
ABSTRACT Optimal cephalexin and cefadroxil dosing for skin and soft tissue infections (SSTIs) is unclear. We summarize clinical and pharmacokinetic/pharmacodynamic (PK/PD) data that compare dosing strategies for SSTIs. Additionally, we conduct population PK target attainment simulations for varying doses of cephalexin and cefadroxil for Staphylococcus ...
Jonathan H. Ryder   +6 more
wiley   +1 more source

Establishing the Epidemiological Cut‐Off Value (ECOFF) for Cefquinome Against Staphylococcus aureus Using Standardised MIC Data

open access: yesVeterinary Medicine and Science, Volume 12, Issue 4, July 2026.
A total of 110 Staphylococcus aureus isolates from cattle were analysed to determine the epidemiological cut‐off value (ECOFF) for cefquinome. Minimum inhibitory concentrations (MICs) were determined using standardised agar dilution and broth microdilution methods following 24 h incubation.
Ijaz Ahmad   +8 more
wiley   +1 more source

Preclinical models for evaluating psychedelics in the treatment of major depressive disorder

open access: yesBritish Journal of Pharmacology, Volume 183, Issue 14, Page 3970-3991, July 2026.
Psychedelic drugs have seen a resurgence in interest as a next generation of psychiatric medicines with potential as rapid‐acting antidepressants (RAADs). Despite promising early clinical trials, the mechanisms which underlie the effects of psychedelics are poorly understood.
Laith Alexander   +5 more
wiley   +1 more source

The Molecular Diagnosis of Myopathies: Integrating Genomic, Proteomic, and Pathological Insights Toward Precision Medicine

open access: yesClinical Genetics, Volume 110, Issue 1, Page 15-28, July 2026.
Advances in genomic, proteomic, and transcriptomic technologies are transforming the diagnosis of genetic myopathies. When integrated with traditional muscle pathology, multi‐omics approaches improve diagnostic yield, clarify disease mechanisms, and support more precise, mechanism‐based therapeutic strategies for patients with neuromuscular disorders ...
Ludmila Alem   +2 more
wiley   +1 more source

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