Results 141 to 150 of about 5,362,679 (291)

Pharmacokinetics of novel anticancer drugs and dynamics of circulating tumor cells in early clinical studies [PDF]

, 2011
Cancer has an enormous impact on the lives of patients and on society and there is an urgent need for improvements in therapy. In this thesis, early-clinical studies into both safety and pharmacokinetics of novel anti-cancer drugs as well as into ...
Devriese, L.A., Clinical Pharmacology, Sub Clinical Pharmacology   +2 more
core   +1 more source

deStruct: Accurate Rearrangement Detection using Breakpoint Specific Realignment

, 2017
We propose that a breakpoint specific alignment procedure would improve breakpoint prediction. Our method, deStruct, uses multiple stages of realignment and clustering to progressively refine breakpoint prediction quality and accuracy.
Sohrab Shah, S. Cenk Sahinalp, Andrew McPherson   +2 more
core   +1 more source

Isolation of carbapenem‐resistant Pseudomonas aeruginosa and other Gram‐negative ESKAPE organisms from samples of raw‐meat diets for dogs in the UK

Veterinary Record, EarlyView.
Abstract Background Gram‐negative ESKAPE organisms are an emerging threat in veterinary medicine that also have zoonotic potential. However, little is known about the prevalence and risks of these organisms in pet food. We present the incidental finding of gram‐negative ESKAPE organisms within samples of raw meat diets for dogs in the United Kingdom ...
Genever Morgan, Nicola Williams, Jenny Llewelyn, Sam Haldenby, Gina Pinchbeck, Dorina Timofte   +5 more
wiley   +1 more source

Impact of a Structured Caesarean Reduction Strategy on Perinatal Outcomes: A Retrospective Ecological Time‐Trend Study

BJOG: An International Journal of Obstetrics &Gynaecology, EarlyView.
ABSTRACT Objective To evaluate the long‐term impact of a structured, multidisciplinary CS reduction strategy in a high‐complexity Italian hospital. Design Retrospective ecological time‐trend study. Setting Tertiary obstetric care Italian centre. Sample 28 577 deliveries, ≥ 22 weeks' gestation, from 2014 to 2024 were analysed.
Stefania Fieni, Giovanni Morganelli, Gabriella Maria Celora, Biancamaria Mastrandrea, Tullio Ghi   +4 more
wiley   +1 more source

Minocycline Activity Against Carbapenem Resistant Acinetobacter baumannii Isolates in a Large Integrated Healthcare System

Antimicrobial Stewardship & Healthcare Epidemiology
Background: Carbapenem-resistant Acinetobacter baumannii (CRAB) infections present treatment challenges due to host-related factors, infection source, and complex resistance mechanisms.
Victoria Gavaghan, Robert Citronberg, Jill Argotsinger   +2 more
doaj   +1 more source

Breakpoint phenological responses in high-Arctic arthropods

Many arthropod species show earlier seasonal activity trends with warming, but these responses cannot continue indefinitely. Beyond a threshold, phenological responses may no longer keep pace with climate change.
Schmidt, Niels M., Høye, Toke T., Holmstrup, Martin, School of Biological Sciences, Gerlich, Hannah Sørine, Aarhus University, Phillimore, Ally; id_orcid   +6 more
core   +1 more source

The company you keep: The influence of popular delinquents and deviant brokers on offending trajectories

Criminology, EarlyView.
Abstract Research on how delinquent peer associations affect individuals’ life courses is limited. This paper addresses this gap by examining delinquent peer network characteristics and their impact on offending trajectories through social network analysis (SNA) and group‐based trajectory modeling (GBTM).
Daniel Trovato
wiley   +1 more source

Assessment of outcome in clinical trials in mild Alzheimer 19s disease: urgent time for a rethink? [PDF]

, 2013
Introduction: A major barrier for clinical trials in Alzheimer's disease is the lack of sensitive clinical endpoints for the early stages. Until recently, regulatory agencies have required demonstration of improvement in two disease domains, cognition ...
McGoldrick, S., Duffy, Fiona, McGoldrick, Susan, Reynish, Emma, Kelly, Fiona, Morrison, Y., Wilson, L., Bennett, Crispin, Wilson, J T Lindsay, Bennett, C., Morrison, Yvonne, Duffy, F., Reynish, E.   +12 more
core  

Evolutionary and Epidemiological Characterization of Multidrug‐Resistant Escherichia coli Isolated From Pangolins in China

Integrative Zoology, EarlyView.
ABSTRACT Malayan pangolin populations have fallen to a critically endangered level, and illegal trafficking of wild pangolins is a global problem. Little is known about antimicrobial‐resistant bacteria (MDRB) harbored by pangolins, although pangolins are frequently consumed as food or used in traditional medicine. In this study, we report for the first
Yawen Wang, Xue Wang, Jianan Zhao, Jun Zeng, Shijia Hu, Fang Ji, Guoying Dong, Hongxuan He, Chengmin Wang   +8 more
wiley   +1 more source

Assessing quality standards of biomarker measurement in first‐trimester combined screening for preeclampsia in the Chinese population: A multicenter study

Acta Obstetricia et Gynecologica Scandinavica, EarlyView.
In 22 066 first‐trimester pregnancies from six Chinese hospitals, biomarker measurements required recalibration to align with the established risk model. Continuous quality assurance is essential to ensure accurate preeclampsia risk assessment when implementing combined screening in new populations.
Jiao Liu, Xiaotian Li, Huixia Yang, Qiongjie Zhou, Hao Ying, Rong Zhou, Yanping Zhang, Wang Xueyin, Han Xie, Xinzhi Tu, Lin Kong, Jie Qin, Chi Chiu Wang, Xiaohong Lu, Long Nguyen‐Hoang, Daljit S. Sahota, Liona C. Poon   +16 more
wiley   +1 more source