Results 141 to 150 of about 67,573 (268)

Experimental evaluation of tenocillin clinical breakpoints against enterobacterales

, 2019
Dans le monde entier l’antibiorésistance des entérobactérales communautaires, notamment par production de ß-lactamase à spectre étendu (E-BLSE), conduit à une consommation préoccupante d’antibiotique de dernier recours tels les carbapénèmes. Dérivé de la ticarcilline la témocilline pourrait représentée une alternative y compris sur certaines ...
openaire   +1 more source

Candidozyma cisalpinoae sp. nov., a Genomically Distinct, Flower‐Associated Yeast, Resistant to Azoles and Exhibiting Pathogenicity‐Related Traits

Yeast, EarlyView.
Candidozyma cisalpinoae sp. nov. represents a distinct species within the Candidozyma clade, supported by multilocus phylogeny, genome‐scale metrics, and phenotypic traits. Although isolated from floral substrates, this species displays several traits commonly associated with opportunistic pathogenic yeasts.
Anna Paula O. Tironi, Katharina O. Barros, Luiz Felipe A. Santana, Daniela L. Souza, Ana Raquel O. Santos, Giovana R. Ávila, Thiago M. Batista, Glória R. Franco, Raphael S. Pimenta, Paula B. Morais, Marc‐André Lachance, Carlos A. Rosa, Susana Johann   +12 more
wiley   +1 more source

Temporal and geographical patterns of nitazene detections in drug samples and biospecimens in the United States, 2019–2024

Addiction, EarlyView.
Abstract Background and aims Nitazenes are a novel subclass of synthetic opioids that have been increasingly implicated in the United States (US) overdose crisis. Despite their growing presence in the illicit drug supply, national trends have not been systematically evaluated.
David T. Zhu, Nicole D. Fitzgerald, Joseph J. Palamar, Alex J. Krotulski   +3 more
wiley   +1 more source

Birth and abortion rates among young women over the past 50 years examined in relation to providers and reimbursement for hormonal contraception across the Nordic countries, an ecological study

Acta Obstetricia et Gynecologica Scandinavica, EarlyView.
Along with the liberalization of the abortion laws in the Nordic countries during the 1970s, there were efforts to prevent unplanned pregnancies among young women by improved contraceptive provisions. The strategies for preventing unplanned pregnancies have varied across the Nordic countries.
Finn Egil Skjeldestad, Mika Gissler, Reynir Tómas Geirsson, Kristina Gemzell‐Danielsson, Oskari Heikinheimo   +4 more
wiley   +1 more source

Optical genome mapping detects cryptic high‐risk and targetable abnormalities in adult AML

British Journal of Haematology, EarlyView.
Summary Acute myeloid leukaemia (AML) risk stratification relies on cytogenetic and molecular abnormalities defined by European LeukemiaNet (ELN) 2022. Conventional cytogenetic techniques, including chromosomal banding analysis (CBA) and fluorescence in situ hybridization, have limited resolution and may miss cryptic events. Optical genome mapping (OGM)
Audrey Bidet, Elodie Laharanne, Manon Dos Santos, Anne‐Charlotte De Grande, Thibaut Leguay, Arnaud Pigneux, Eric Frison, Sandrine Achard, Stéphanie Dupont‐Moufakkir, Emilie Klein, Pierre‐Yves Dumas   +10 more
wiley   +1 more source

Chemotherapy‐driven expression of WNT ligands in bone marrow stromal cells contributes to chemoresistance in acute lymphoblastic leukaemia

British Journal of Haematology, EarlyView.
Chemotherapy‐induced WNT ligand secretion by bone marrow (BM) stroma drives acute lymphoblastic leukaemia (ALL) chemoresistance. WNT pathway inhibition disrupts this cross‐talk and restores therapeutic response, highlighting WNT inhibitors as a promising strategy to prevent relapse in ALL.
Foteini Kalampalika, Amanda Jiménez‐Pompa, Raúl Sánchez‐Lanzas, Bela Patel, Miguel Ganuza   +4 more
wiley   +1 more source

Progressive Mauve: Multiple alignment of genomes with gene flux and rearrangement [PDF]

, 2009
Multiple genome alignment remains a challenging problem. Effects of recombination including rearrangement, segmental duplication, gain, and loss can create a mosaic pattern of homology even among closely related organisms.
Darling, Aaron E., Mau, Bob, Perna, Nicole T.   +2 more
core  

Two Cases of SPEN Haploinsufficiency Presenting with Dystonia: Expanding the Genotype and Phenotype

Movement Disorders Clinical Practice, EarlyView.
Lisa Buikema, Matej Lokar, Saman Vinke, Borut Peterlin, Gaber Bergant, Dejan Georgiev   +5 more
wiley   +1 more source

Preclinical models for evaluating psychedelics in the treatment of major depressive disorder

British Journal of Pharmacology, EarlyView.
Psychedelic drugs have seen a resurgence in interest as a next generation of psychiatric medicines with potential as rapid‐acting antidepressants (RAADs). Despite promising early clinical trials, the mechanisms which underlie the effects of psychedelics are poorly understood.
Laith Alexander, Dasha Anderson, Luke Baxter, Matthew Claydon, James Rucker, Emma S. J. Robinson   +5 more
wiley   +1 more source

Prevalence and Spectrum of Congenital Heart Disease in Individuals With Distal Chromosome 22q11.22–23 Deletions

Clinical Genetics, EarlyView.
The frequency and severity of congenital heart disease vary extensively in individuals with 22q11.22–23 distal deletions. Reduced gene dosage particularly within the low copy repeat (LCR22) D–E region including MAPK1 and HIC2 conveys risk for these defects.
Tanner J. Nelson, Daniel E. McGinn, T. Blaine Crowley, Lydia Rockart, Audrey Green, Victoria Giunta, Oanh Tran, Daniella Miller, Jeroen Breckpot, Ann Swillen, M. Cristina Digilio, Marta Unolt, Carolina Putotto, Federica Pulvirenti, Bruno Marino, Beverly S. Emanuel, Elaine H. Zackai, Zhengdong D. Zhang, Elizabeth Goldmuntz, Erik Boot, Anne S. Bassett, Bernice E. Morrow, Donna M. McDonald‐McGinn   +22 more
wiley   +1 more source