Results 161 to 170 of about 68,369 (257)

Incidence patterns and temporal trends of childhood cancer in Germany, 1980–2019: Forty years of childhood cancer registration in Germany

International Journal of Cancer, Volume 158, Issue 6, Page 1541-1554, 15 March 2026.
What's new? Childhood cancer ranks among the leading causes of disease‐related deaths in children in high‐income countries. Established risk factors, however, account for only a small proportion of incident childhood cancers. In this report, the authors present the first long‐term assessment of temporal trends in childhood cancer incidence rates in ...
Friederike Erdmann, Maike Wellbrock, Claudia Trübenbach, Desiree Grabow, Martin Schrappe, Peter Kaatsch, Claudia Spix, Joachim Schüz, Cécile M. Ronckers   +8 more
wiley   +1 more source

Aging‐Derived Alterations in Genomic, Immune, and Metabolic Networks: Implications for Cancer Development and Therapy

MedComm – Oncology, Volume 5, Issue 1, March 2026.
Ageing acts as a double‐edged sword in cancer. In the elderly, open chromatin, immunosenescence, and chronic inflammation drive SASP (IL‐6, MMPs), MDSC accumulation and T‐cell suppression, fostering tumor‐promoting microenvironments and limited therapeutic benefit.
Qi Wang, Xue Sun, Xinhao Han, Xingda Zhang, Wenzheng Wang, Hongbin Wang, He Ren, Lina Gu   +7 more
wiley   +1 more source

RELEVANCE OF DELETION BREAKPOINT SPECIFICATION IN 22q11.2 DELETION SYNDROME: CLINICAL MANAGEMENT OF THREE ILLUSTRATIVE PATIENTS

Clinical Neuropsychiatry, 2018
Contains fulltext : 197326.pdf (Publisher’s version ) (Open Access)
Verhoeven, W.M.A., Egger, J.I.M., Leeuw, N. de   +2 more
openaire   +2 more sources

Genomic Sequencing and Analysis of New Variants of Enzootic Nasal Tumour Virus Type 2 Revealed Recombination Events between Different Sublineages

Veterinary Medicine and Science, Volume 12, Issue 2, March 2026.
The strains from sublineages 1.5 and 1.2 may be promoting the emergence of new strains of ENTV‐2 in China. Recombination drives ENTV‐2's rapid evolution . ABSTRACT In recent years, multiple regions in China have experienced an increase in the occurrence of enzootic nasal tumour virus type 2 (ENTV‐2) infections. This research highlights the initial full
Yong Pan, Li Yang, Ting Li, Jinge Xu, Qiufan Xu, Qi Yang   +5 more
wiley   +1 more source

Molecular Landscape in Limb Anomalies: Diagnostic Yield and New Candidate Genes

Clinical Genetics, Volume 109, Issue 3, Page 424-436, March 2026.
In 132 individuals with limb anomalies, diagnostic yield was 36% (47/132), including 25 novel variants, three cases with new phenotypes, and two candidate loci, HOXA11 and a small 2q31.1 deletion. Mouse data and exome‐wide analysis, key in identifying the candidate loci, represent an important opportunity for gene discovery.
Akram Mokhtari, Jade Charbonneau, Valancy Miranda, Khadijé Jizi, Marie‐Ange Delrue, Patricia Egerszegi, Isabelle Thiffault, Philippe M. Campeau   +7 more
wiley   +1 more source

High Concordance of Copy Number Variants Detected by Chromosomal Microarray and Exome Sequencing in Clinical Diagnostics

Clinical Genetics, Volume 109, Issue 3, Page 529-538, March 2026.
To assess the relevance of exome sequencing as a first‐tier diagnostic tool, three aspects were investigated: detection of copy number variants (CNVs) from exomes as compared to chromosomal microarray, clinically‐relevant CNVs across all sizes, and additional diagnostic utilities (uniparental disomy and triploidy).
Rivka Birnbaum, Maya Slovik, Shamir Zenvirt, Ilana Livyatan, Israel Altman, Shiri Gershon, Jonathan Rips, Hagit Daum, Chaggai Rosenbluh, Orly Elpeleg, Vardiella Meiner, Ayala Frumkin, Hagar Mor‐Shaked, Tamar Harel   +13 more
wiley   +1 more source

Machine learning for personalized antimicrobial susceptibility breakpoints. [PDF]

J Antimicrob Chemother
Zhong Y, Hope W, Buchan I, Velluva A, Gerada A, Rosato C, Green PL, Howard A.   +7 more
europepmc   +1 more source

Clinically Irrelevant Terminal 16q21 Deletion Detected by NIPT Is Attributable to Inherited Fragility at FRA16B

American Journal of Medical Genetics Part A, Volume 200, Issue 2, Page 348-352, February 2026.
ABSTRACT Genome‐wide non‐invasive prenatal testing (NIPT) is a powerful tool for prenatal detection of the common aneuploidies causing Down‐, Edwards‐, and Patau syndrome. Its genome‐wide reach also enables the detection of unbalanced structural chromosomal abnormalities.
Servi J. C. Stevens, Wanwisa van Dijk, Nicole Y. Souren, Merryn V. E. Macville, Guillaume van de Zande, Brigitte H. W. Faas, Bart de Koning, Arthur van den Wijngaard, Sonja de Munnik, Masoud Zamani Esteki   +9 more
wiley   +1 more source

Sentinel Lymph‐Node Biopsy Guided Neck Dissection Versus Elective Neck Dissection in the Management of Early‐Stage Oral Cancer—A Cost‐Utility Analysis

Cancer Medicine, Volume 15, Issue 2, February 2026.
ABSTRACT Objectives This study aims to assess the incremental cost per quality‐adjusted‐life‐year (QALY) gained in treating patients with early oral squamous cell carcinoma (OSCC) using sentinel lymph node biopsy (SLNB) guided neck dissection. Methods A Markov model was created to simulate disease‐free survival, recurrence, and overall survival in a ...
Shivakumar Thiagarajan, Shweta Sharda, Yashika Chugh, Nidhi Gupta, C. S. Pramesh, Shankar Prinja   +5 more
wiley   +1 more source

Acute Hypoxia Decreases Maximum Fat Oxidation Rate During Step Incremental Exercise Normalized to Respiratory Compensation Point

European Journal of Sport Science, Volume 26, Issue 2, February 2026.
ABSTRACT Whether fat oxidation (FATox) is altered during exercise in hypoxia remains equivocal due to differences in experimental protocols. Furthermore, to date no investigation has reported the effect of hypoxia on maximal fat oxidation rate (MFO).
Youmna Elsayed Hassanein, Dania Ibrahim, Juan M. Murias, Nathan Townsend   +3 more
wiley   +1 more source