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First-trimester SPISE mediates the association between early-pregnancy body fat percentage change and gestational diabetes mellitus: an exploratory secondary analysis of a prospective cohort. [PDF]

Front Endocrinol (Lausanne)
Zhang X, Guo M, Chen Y.
europepmc   +1 more source

Comprehensive evaluation of structural variation detection for germline and somatic analysis with long-read sequencing data. [PDF]

Brief Bioinform
Shi H, Lin Y, Liu D, Wu H, Mat Isa AN, Wei L, Zou Q, Chen X.   +7 more
europepmc   +1 more source

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Breaking Down the Breakpoints: Rationale for the 2022 Clinical and Laboratory Standards Institute Revised Piperacillin-Tazobactam Breakpoints Against Enterobacterales

Clinical Infectious Diseases, 2022
Abstract Piperacillin-tazobactam (PTZ) is one of the most common antibiotics administered to hospitalized patients. Its broad activity against gram-negative, gram-positive, and anaerobic pathogens; efficacy in clinical trials across diverse infection types and patient populations; and generally favorable toxicity profile make it a ...
Pranita D Tamma, Patrick N A Harris, Amy J Mathers, Eric Wenzler, Romney M Humphries   +4 more
openaire   +4 more sources

Comparison of antimicrobial pharmacokinetic/pharmacodynamic breakpoints with EUCAST and CLSI clinical breakpoints for Gram-positive bacteria

International Journal of Antimicrobial Agents, 2012
This study compared the susceptibility breakpoints based on pharmacokinetic/pharmacodynamic (PK/PD) models and Monte Carlo simulation with those defined by the Clinical and Laboratory Standards Institute (CLSI) and the European Committee on Antimicrobial Susceptibility Testing (EUCAST) for antibiotics used for the treatment of infections caused by Gram-
Eduardo, Asín, Arantxazu, Isla, Andrés, Canut, Alicia, Rodríguez Gascón   +3 more
openaire   +2 more sources

Carbapenem susceptibility breakpoints, clinical implications with the moving target

Expert Review of Anti-infective Therapy, 2016
Carbapenems are primary agents used to treat a variety of Gram-negative multi-drug resistant infections. In parallel with increasing use, increasing resistance to carbapenem agents has manifested as increased minimum inhibitory concentrations (MICs). To attempt to improve clinical outcomes with carbapenems, the Clinical Laboratory Standards Institute ...
J Nicholas, O'Donnell, Cristina M, Miglis, Jane Y, Lee, Merika, Tuvell, Tina, Lertharakul, Marc H, Scheetz   +5 more
openaire   +2 more sources

Prevalence, breakpoint distribution, and clinical correlates of t(5;12)

Cancer Genetics and Cytogenetics, 2004
Among 56,709 cytogenetic studies performed during a 15-year period at the Mayo Clinic, 25 cases of t(5;12) were identified. Among 11 patients with available clinical information, 4 had myelodysplastic syndrome, 2 had acute myelocytic leukemia, 2 had myelofibrosis with myeloid metaplasia (MMM), 2 had atypical chronic myelocytic disorder (ACMD), and 1 ...
Patricia T, Greipp, Gordon W, Dewald, Ayalew, Tefferi   +2 more
openaire   +2 more sources