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Breakpoints in Antibiotic Sensitivity Testing and Their Clinical Relevance
Journal of Chemotherapy, 1997Antibiotic sensitivity testing has been developed into a highly sophisticated process technically. Interpretation of results obtained requires the definition of breakpoints in order to separate sensitive (likely to respond to treatment) from resistant (likely to persist despite treatment) strains. Various methods used for the setting of breakpoints are
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Can We Achieve Clinical Breakpoints for the Triazoles in Aspergillosis?
Current Fungal Infection Reports, 2011The azoles are first-line agents for the treatment of aspergillosis. A number of recent studies have shown increasing rates of resistance in A. fumigatus. Consequently, reliable in vitro susceptibility testing and breakpoints that appropriately classify resistant isolates are of paramount importance.
Juan Luis Rodriguez-Tudela +5 more
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Infection, 2009
Since the origin of an "'International Collaborative Study on Antibiotic Sensitivity Testing'" in 1971, considerable advancement has been made to standardize clinical susceptibility testing procedures of antimicrobial agents. However, a consensus on the methods to be used and interpretive criteria was not reached, so the results of susceptibility ...
A, Dalhoff, P G, Ambrose, J W, Mouton
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Since the origin of an "'International Collaborative Study on Antibiotic Sensitivity Testing'" in 1971, considerable advancement has been made to standardize clinical susceptibility testing procedures of antimicrobial agents. However, a consensus on the methods to be used and interpretive criteria was not reached, so the results of susceptibility ...
A, Dalhoff, P G, Ambrose, J W, Mouton
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Acta Haematologica, 2009
Cytogenetic study in a case of acute myelogenous leukemia revealed the presence of two identical dicentric marker chromosomes derived from an X with Xq13 breakpoints. Clinical and cytochemical findings suggest that the patient was affected by idiopathic acquired sideroblastic anemia before the acute leukemia.
SESSAREGO, MARIO +3 more
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Cytogenetic study in a case of acute myelogenous leukemia revealed the presence of two identical dicentric marker chromosomes derived from an X with Xq13 breakpoints. Clinical and cytochemical findings suggest that the patient was affected by idiopathic acquired sideroblastic anemia before the acute leukemia.
SESSAREGO, MARIO +3 more
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International Journal of Antimicrobial Agents, 2021
The application of cefepime breakpoint for carbapenem-resistant Klebsiella pneumoniae (CRKP) bacteraemia has not been explored. Adult cases of monomicrobial bloodstream infection (BSI) caused by cefepime-susceptible [minimum inhibitory concentration (MIC) ≤8 mg/L] K.
Nan-Yao Lee +6 more
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The application of cefepime breakpoint for carbapenem-resistant Klebsiella pneumoniae (CRKP) bacteraemia has not been explored. Adult cases of monomicrobial bloodstream infection (BSI) caused by cefepime-susceptible [minimum inhibitory concentration (MIC) ≤8 mg/L] K.
Nan-Yao Lee +6 more
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MIC and clinical efficacy. From systemic to ocular breakpoints
Acta Ophthalmologica, 2008AbstractAbstract not ...
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The Relationship Between the Location of the Breakpoint Within the M-BCR and Clinical Parameters
Leukemia & Lymphoma, 1993The Philadelphia chromosome (t9;22)(q34;q11) is a characteristic abnormality in chronic myeloid leukemia. In greater than 95% of the cases, the breakpoint occurs with the M-bcr region of the BCR gene on chromosome 22. Several studies have attempted to correlate the location of the breakpoint within the M-bcr with a clinical parameter.
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Journal of Infection and Chemotherapy, 2012
The pharmacokinetics-pharmacodynamics (PK-PD) breakpoint of piperacillin/tazobactam (PIPC/TAZ) for hospital-acquired pneumonia (HAP) and Pseudomonas aeruginosa-induced bacteremia is controversial, since the susceptibility of P. aeruginosa to PIPC/TAZ is known to be lower than that set by the Clinical Laboratory Standards Institute (CLSI), ≤64 mg/L. The
Yuka, Yamagishi +5 more
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The pharmacokinetics-pharmacodynamics (PK-PD) breakpoint of piperacillin/tazobactam (PIPC/TAZ) for hospital-acquired pneumonia (HAP) and Pseudomonas aeruginosa-induced bacteremia is controversial, since the susceptibility of P. aeruginosa to PIPC/TAZ is known to be lower than that set by the Clinical Laboratory Standards Institute (CLSI), ≤64 mg/L. The
Yuka, Yamagishi +5 more
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Seminars in Pediatric Infectious Diseases, 2004
Antimicrobial susceptibility test breakpoints are necessary for the correct clinical interpretation of quantitative or qualitative susceptibility test values of antibacterial agents. Breakpoints are selected by regulatory bodies or professional groups (eg, the National Committee for Clinical Laboratory Standards) based on an extensive review of the ...
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Antimicrobial susceptibility test breakpoints are necessary for the correct clinical interpretation of quantitative or qualitative susceptibility test values of antibacterial agents. Breakpoints are selected by regulatory bodies or professional groups (eg, the National Committee for Clinical Laboratory Standards) based on an extensive review of the ...
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