Results 101 to 110 of about 453,652 (299)

Breast examination as a cost-effective screening tool in a clinical practice setting in Ibadan, Nigeria

African Journal of Primary Health Care & Family Medicine, 2013
Background: Breast cancer is a disease of public health importance. It results in high morbidity and mortality in women worldwide. The high morbidity and mortality from breast cancer can be decreased by measures targeted at early detection such as ...
Adetola M. Ogunbode, Akinola A. Fatiregun, Olayinka O. Ogunbode, Lawrence A. Adebusoye   +3 more
doaj   +3 more sources

Interval Breast Cancers in Mass Screening by Clinical Breast Examination with Mammography: Comparison with Clinical Breast Examination Alone.

Nihon Nyugan Kenshin Gakkaishi (Journal of Japan Association of Breast Cancer Screening), 1996
1989年より50歳以上女性23,783人に対して, 視触診とマンモグラフィー方向撮影を併用した乳癌の集団検診を行った (検診間隔は2年)。1994年3月までに797人 (3.35%) が要精検となり, 54人 (発見率0.22%) の乳癌患者が発見され, 中間期乳癌は3人登録された。3例の内訳は, 検診後7カ月に診断されたStage IIIa症例と, 検診後20カ月と23カ月目にそれぞれ診断されたStage I症例であった。検診後1年以内の中間期乳癌を検診の偽陰性と定義すると, 偽陰性例は1例のみで, 併用検診の感度は98.2%, 特異度は96.9%, 陽性予知度は6.7%であった。一方, 同時期の視触診のみの検診を受けた50歳以上の女性は82,568人で, 3,551人 (4.30 ...
Koji Ohnuki, Noriaki Ohuchi, Koichi Yoshida, Michio Kimura, Akio Ouchi, Ken-ichi Shiiba, Ken-ichi Yokota, Seiki Matsuno   +7 more
openaire   +2 more sources

KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer

Molecular Oncology, EarlyView.
Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan, Veronika M Metzler, Simone de Brot, Corinne L Woodcock, Anna E Harris, Jennifer Lothion‐Roy, Emeli M Nilsson, Atara Ntekim, Michael S Toss, Jenny L Persson, Francesca Khani, Brian D Robinson, Lorraine J Gudas, Emad Rakha, David M Heery, Catrin S Rutland, Nigel P Mongan   +16 more
wiley   +1 more source

Unusual skin metastasis due to adenocarcinoma of the stomach: a case report [PDF]

, 2011
Clinical Findings A 68- year-old man presented with a skin thickening of the anterior neck started few months earlier. Upper respiratory and digestive tract had already been examined which proved normal.
Cerio, Rino, Piras, Daniela, Pruneddu, Sara, Wijesuriya, Nilukshi   +3 more
core  

Tolerance and safety evaluation of N, N-dimethylglycine, a naturally occurring organic compound, as a feed additive in broiler diets [PDF]

, 2009
N, N-dimethylglycine (DMG) is a tertiary amino acid that naturally occurs as an intermediate metabolite in choline-to-glycine metabolism. The objective of the present trial was to evaluate tolerance, safety and bioaccumulation of dietary DMG in broilers ...
Kalmar, I.D., Verstegen, M.W.A., Maenner, K., Zentek, J., Meulemans, G., Janssens, G.P.J.   +5 more
core   +1 more source

Adaptor protein CIN85 potentiates the motility of osteosarcoma cells via the Akt/mTOR and MMP2‐COL3A1 axis

Molecular Oncology, EarlyView.
CIN85 is highly expressed in osteosarcoma, particularly in metastatic lesions. Its overexpression increases cell migration and Matrigel invasion, while silencing CIN85 suppresses these behaviors. Transcriptome analysis shows that CIN85 regulates MMP2, COL3A1, and Akt/mTOR signaling. Targeting these pathways reverses CIN85‐induced motility, highlighting
Iryna Horak, Iva Staniczková Zambo, Matěj Přikryl, Peter Múdry, Danica Zapletalová, Jarmila Navrátilová, Jiří Navrátil, Jan Šmarda, Liudmyla Drobot, Petr Beneš, Lucia Knopfová   +10 more
wiley   +1 more source

Breast Cancer Prevention and Management: A Primer for General Practitioners

Preventive Medicine: Research & Reviews
Breast cancer is the most common malignancy among women in India and a significant contributor to cancer-related mortality. Early detection and evidence-based clinical interventions can substantially reduce the burden of breast cancer-related morbidity ...
Neha Singh, Khushboo Bhange, Kamlesh K Jain, Kanika Arora, Jitendra K. Meena   +4 more
doaj   +1 more source

The Clinical Breast Examination: A Useful Screening Tool?

Journal of Patient-Centered Research and Reviews, 2015
The standardization of the clinical breast examination as a screening tool for breast cancer has been a topic of controversy. Current recommendations vary significantly from organization to organization without consensus. There currently does not seem to
Jennifer Lo
doaj   +1 more source

Metaplastic Carcinoma of the Left Breast with Extensive Chondroid Differentiation [PDF]

, 2011
Metaplastic breast carcinoma is very rare neoplasm which contains mixture of carcinomatous (epithelial) and sarcomatous (mesenchymal) elements in variable proportion. Metaplastic carcinoma with chondroid differentiation is even rarer.
Bohra, Ashish, Jagtap, Sunil V, Jain, Gaurav, Kanetkar, Sujata R, Nikumbh, Dhiraj B   +4 more
core   +1 more source

Interaction of HS1BP3 with cortactin modulates TKS5 localisation, cell secretion and cancer malignancy

Molecular Oncology, EarlyView.
Here, we demonstrate that HS1BP3 interacts with Cortactin through a proline‐rich region (PRR3.1) and show that this interaction, and HS1BP3 itself, promote cancer cell proliferation and invasion. Inhibition of this interaction leads to build‐up of TKS5 in multivesicular endosomes and altered secretion of CD63 and CD9, providing an explanation for the ...
Arja Arnesen Løchen, Kristiane Søreng, Chiara Veroni, Laura Trachsel‐Moncho, Nagham Asp, Robin Gaupset, Lars Gustav Lyckander, Helene Knævelsrud, Lars Eftang, Anne Simonsen   +9 more
wiley   +1 more source