Results 51 to 60 of about 453,652 (299)

An association of boswellia, betaine and myo-inositol (Eumastós) in the treatment of mammographic breast density. A randomized, double-blind study [PDF]

, 2015
Mammographic breast density is a recognized risk factor for breast cancer. The causes that lead to the proliferation of the glandular breast tissue and, therefore, to an increase of breast density are still unclear.
Alwasel, S. H, BIZZARRI, Mariano, CUCINA, Alessandra, Giuliani, A, Gullo, G, Harrath, A. H, PASTA, Vittorio, TARTAGLIA, Francesco   +7 more
core  

Potential therapeutic targeting of BKCa channels in glioblastoma treatment

Molecular Oncology, EarlyView.
This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak, Karolina Pytlak, Sandra Jaworowska, Bogusz Kulawiak, Piotr Bednarczyk   +4 more
wiley   +1 more source

Exploring factors associated with breast cancer screening among women aged 15 - 49 years in Lesotho

The Pan African Medical Journal, 2021
INTRODUCTION: Breast cancer is associated with serious morbidity, low quality of life and mortality. Prevention through early screening remains one of the most optimal strategies against breast cancer.
Kanono Thabane, Yolisa Mashologu, Lehana Thabane   +2 more
doaj   +1 more source

PARP inhibition and pharmacological ascorbate demonstrate synergy in castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon, Peter T. Gallagher, Orly I. Richter, Neermala Poudel Neupane, Amy C. Mandigo, Jennifer J. McCann, Emanuela Dylgjeri, Irina Vasilevskaya, Christopher McNair, Channing J. Paller, Wm. Kevin Kelly, Karen E. Knudsen, Matthew J. Schiewer, Ayesha A. Shafi   +13 more
wiley   +1 more source

Awareness on Breast Cancer among the Women of Reproductive Age

Journal of Family and Reproductive Health, 2011
Objective: To assess the level of awareness on breast cancer among women of reproductive age. Materials and methods: A cross-sectional descriptive study was conducted in OPD of Dhaka Medical College Hospital among the 175 respondents by face to face ...
Shahanaz Chowdhury, Shaila Sultana
doaj  

Fighting breast cancer in low-and-middle-income countries – What must we do to get every woman screened on regular basis?

Scientific African, 2023
Background and Purpose: Currently, the incidence of female breast cancer has surpassed all other cancers globally. In low-and-middle-income countries (LMICs), breast cancer incidence is relatively lower than it is in high-income countries (HICs). However,
Eric Naab Manson, Daniel Gyingiri Achel
doaj   +1 more source

LDAcoop: Integrating non‐linear population dynamics into the analysis of clonogenic growth in vitro

Molecular Oncology, EarlyView.
Limiting dilution assays (LDAs) quantify clonogenic growth by seeding serial dilutions of cells and scoring wells for colony formation. The fraction of negative wells is plotted against cells seeded and analyzed using the non‐linear modeling of LDAcoop.
Nikko Brix, Daniel Samaga, Katharina Gehr, Benedek Dankó, Mohamed Schumann, Guido Drexler, Ahmed Alnatsha, Georg Beyer, Ujjwal Mahajan, Martin Selmansberger, Julia Mayerle, Claus Belka, Horst Zitzelsberger, Kirsten Lauber   +13 more
wiley   +1 more source

Knowledge, attitude, and behavior among Saudis toward cancer preventive practice

Journal of Family and Community Medicine, 2011
Objective: To examine self-reported knowledge, attitude, and preventive practices on cancer among Saudis. Materials and Methods: Data was collected from Saudis aged 15 years or more, who attended one of the randomly selected 20 Primary Health Centers ...
Kandasamy Ravichandran, Nasser A Al-Hamdan, Gamal Mohamed   +2 more
doaj   +1 more source

Twenty five year follow-up for breast cancer incidence and mortality of the Canadian national breast screening study: randomised screening trial [PDF]

, 2014
Annual mammography in women aged 40-59 does not reduce mortality from breast cancer beyond that of physical examination or usual care when adjuvant therapy for breast cancer is freely available.
Anthony B. Miller, Claus Wall, Cornelia J. Baines, Ping Sun, Steven A. Narod, Teresa To   +5 more
core   +1 more source

Therapeutic strategies for MMAE‐resistant bladder cancer through DPP4 inhibition

Molecular Oncology, EarlyView.
We established monomethyl auristatin E (MMAE)‐resistant bladder cancer (BC) cell lines by exposure to progressively increasing concentrations of MMAE in vitro. RNA sequencing showed DPP4 expression was increased in MMAE‐resistant BC cells. Both si‐DPP4 and the DPP4 inhibitor sitagliptin suppressed the viability of MMAE‐resistant BC cells.
Gang Li, Shuichi Tatarano, Hirofumi Yoshino, Saeki Saito, Mitsuhiko Tominaga, Junya Arima, Ikumi Fukuda, Takashi Sakaguchi, Ryosuke Matsushita, Yasutoshi Yamada, Hideki Enokida   +10 more
wiley   +1 more source