Results 61 to 70 of about 7,450,889 (232)

Breast Hamartoma: Clinical, Radiological, and Histopathological Evaluation

European Journal of Breast Health, 2021
Objective:Breast hamartomas are rare, benign, and slow-growing breast tumors that can be definitively diagnosed by combining the results of clinical, radiological, and histopathological examination. This study aimed to evaluate the clinical, radiological,
Deniz Tazeoğlu, Ahmet Dağ, Bilal Arslan, Mustafa Berkeşoğlu   +3 more
doaj   +1 more source

Finding novel vulnerabilities of hypomorphic BRCA1 alleles

Molecular Oncology, EarlyView.
Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder, Klaas de Lint, Hồ Mỹ Phúc Võ, Mariana M. Góis, Rosalie A. Kampen, Marta San Martin Alonso, Ilse Nootenboom, Veronica Garzero, Tiemen J. Wendel, Rob M. F. Wolthuis, Sylvie M. Noordermeer   +10 more
wiley   +1 more source

Assessment of the national breast cancer screening program outcomes in the Skhirat-Temara prefecture from 2020 to 2024

Discover Public Health
Context Breast cancer tops the list of cancer fatalities globally amongst women. It is fast growing in Morocco, where it accounts for 39% of female cancers.
Aicha Elalami, Zaynab Boujelb, Zaki El Hanchi, Hafid Hachi, Hasna Ahyayauch, Abdelhalem Mesfioui   +5 more
doaj   +1 more source

MITF maintains genome stability in nonmelanocyte lineages

Molecular Oncology, EarlyView.
MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir, Adrián López García de Lomana, Thejus B. Venkatesh, Kritika Kirty, Snaevar Sigurdsson, Linda Vidarsdottir, Ramile Dilshat, Erla Sveinbjornsdottir, Snaedis Ragnarsdottir, Daniel H Magnusson, Maria R. Bustos, Eirikur Steingrimsson, Thorkell Gudjonsson, Stefan Sigurdsson   +13 more
wiley   +1 more source

Outcome and human epidermal growth factor receptor (HER) 1-4 status in invasive breast carcinomas with proliferation indices evaluated by bromodeoxyuridine labelling [PDF]

, 2004
Background: We have shown previously that whereas overexpression of human epidermal growth factor receptor (HER) 1, HER2 and HER3 is associated with poor prognosis in breast cancer, HER4 is associated with a good prognosis.
Reeves, J.R., Cooke, T.G., Caroline J Witton, Peter D Stanton, Timothy G Cooke, John MS Bartlett, Witton, C.J., Tovey, S.M., Bartlett, J.M.S., Sian M Tovey, Jonathan R Reeves, Stanton, P.D.   +11 more
core   +2 more sources

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

Clinical usefulness of cancer markers in primary breast cancer [PDF]

, 2011
The aim of this study was to investigate the diagnostic power of CA 549, MSA and CA 15-3 in identifying breast cancer. The study included 232 patients of which 56 were healthy, 43 had benign breast cancer and 191 with other growths.
Verring, A., Ziolkowski, Piotr, Oremek, Gerhard, Clouth, Aline   +3 more
core   +1 more source

Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization

Molecular Oncology, EarlyView.
In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu, Nicolas J. Niklaus, Anna M. Schläfli, Igor Tokarchuk, Magali Humbert, Federico La Manna, Bich Vu, David Maul, Ramin Radpour, Marianna Kruithof‐de Julio, Inti Zlobec, Jörn Dengjel, Bruce E. Torbett, Mario P. Tschan   +13 more
wiley   +1 more source

Survival analysis of 1148 women diagnosed with breast cancer in Southern Iran [PDF]

, 2009
Background: while there has been much research regarding risk factors and prognostic factors for breast cancer in general, research specific to Iran is sparse.
Talei, Abdolrasoul, Rezaianzadeh, Abbas, Daniel Reidpath, Reidpath Daniel, Reidpath, D, Peacock, J, Hosseini, SV, Talei Abdolrasoul, Hosseini, Seyed Vahid, Hosseini, Seyed Vahid, Seyed Hosseini, Rezaianzadeh Abbas, Davood Mehrabani, Talei, A, Janet Peacock, Hoseini Seyed, Mehrabani, D, Mehrabani Davood, Rezaianzadeh, A, Peacock, Janet, Hosseini, S.V, Peacock Janet, Seyed Vahid Hosseini, Peacock, J.L, Mehrabani, Davood, Reidpath, Daniel, Abdolrasoul Talei, Reidpath, DD, Abbas Rezaianzadeh   +28 more
core   +2 more sources

Inhibition of cyclin‐dependent kinases 12/13 using CT7439 as a treatment for colorectal cancer with CDK12 upregulation

Molecular Oncology, EarlyView.
The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington, Divya L. Dayanidhi, Mohammad Zokaasadi, John B. Mantyh, Pelumi D. Olawuni, Gabrielle Rupprecht, Jeremy M. Force, Shannon McCall, Ashwani K. Bahl, David S. Hsu, Jason A. Somarelli   +10 more
wiley   +1 more source