Results 61 to 70 of about 2,986,872 (249)

Enteropathogenic E. coli shows delayed attachment and host response in human jejunum organoid‐derived monolayers compared to HeLa cells

FEBS Letters, EarlyView.
Enteropathogenic E. coli (EPEC) infects the human intestinal epithelium, resulting in severe illness and diarrhoea. In this study, we compared the infection of cancer‐derived cell lines with human organoid‐derived models of the small intestine. We observed a delayed in attachment, inflammation and cell death on primary cells, indicating that host ...
Mastura Neyazi, Pilar Samperio Ventayol, Natalie Burkard, Nicolas Schlegel, Carmen Aguilar, Sina Bartfeld   +5 more
wiley   +1 more source

Organoids in pediatric cancer research

FEBS Letters, EarlyView.
Organoid technology has revolutionized cancer research, yet its application in pediatric oncology remains limited. Recent advances have enabled the development of pediatric tumor organoids, offering new insights into disease biology, treatment response, and interactions with the tumor microenvironment.
Carla Ríos Arceo, Jarno Drost
wiley   +1 more source

A Novel Approach to Clinical Change Endpoints: A Win Ratio Analysis of the INCREASE Trial. [PDF]

Ann Am Thorac Soc, 2023
Nathan SD, Medarov B, Ho L, Kingrey J, Hong T, Rao Y, Shen E, Smith P, Deng C, Waxman A.   +9 more
europepmc   +1 more source

Reciprocal control of viral infection and phosphoinositide dynamics

FEBS Letters, EarlyView.
Phosphoinositides, although scarce, regulate key cellular processes, including membrane dynamics and signaling. Viruses exploit these lipids to support their entry, replication, assembly, and egress. The central role of phosphoinositides in infection highlights phosphoinositide metabolism as a promising antiviral target.
Marie Déborah Bancilhon, Bruno Mesmin
wiley   +1 more source

Clinical research changing clinical practice

Injury, 2023
Peter, Augat, Hamish, Simpson, Volker, Alt   +2 more
openaire   +2 more sources

Referral to and Engagement with Pulmonary Rehabilitation: A Review and Strategic Behavioural Analysis of Factors Influencing Behaviour and Intervention Opportunities

International Journal of COPD
Amanda P Moore,1 Isolt Reardon,1 Osanna Ramkissoon,1 Frances Early,2 Estelle Payerne,3 Polly-Anna Ashford,3 Stephen Holmes,4 Michael P Kelly,5 Sally J Singh,6 GM Monsur Habib,7 Jonathan Fuld,8 Fabiana Lorencatto1 On behalf of the UPTURN Team1Centre for ...
Moore AP, Reardon I, Ramkissoon O, Early F, Payerne E, Ashford PA, Holmes S, Kelly MP, Singh SJ, Habib GM, Fuld J, Lorencatto F   +11 more
doaj  

Modelling malaria environmental suitability and population exposure using the analytic hierarchy process among local government areas in Bayelsa State, Nigeria

Discover Public Health
Background Persistent malaria transmission in Africa underscores the need for spatially explicit tools that identify highly endemic areas for targeted control. Although multi-criteria decision analysis (MCDA) offers a structured approach, its application
Okpachi Christopher Abbah, Olalekan John Taiwo, James Olaoye Oyeleye, Ganiyat Eshikhena, Tamaraebi Borme, German Wisdom, Dupsy Akoma, Fayokemi Olususi, Ifeoma Ezenyi, Chioma Unogu, Kaduru Chijioke   +10 more
doaj   +1 more source

Spatiotemporal and quantitative analyses of phosphoinositides – fluorescent probe—and mass spectrometry‐based approaches

FEBS Letters, EarlyView.
Fluorescent probes allow dynamic visualization of phosphoinositides in living cells (left), whereas mass spectrometry provides high‐sensitivity, isomer‐resolved quantitation (right). Their synergistic use captures complementary aspects of lipid signaling. This review illustrates how these approaches reveal the spatiotemporal regulation and quantitative
Hiroaki Kajiho, Shin Morioka, Junko Sasaki, Takehiko Sasaki   +3 more
wiley   +1 more source

Behavioural Systems Mapping of Solid Waste Management in Kisumu, Kenya, to Understand the Role of Behaviour in a Health and Sustainability Problem

Behavioral Sciences
Poor solid waste management in Kisumu, Kenya, contributes to adverse health, social, and environmental outcomes as a result of open burning, illegal dumping, and reliance on landfills.
Joanna Davan Wetton, Micaela Santilli, Hellen Gitau, Kanyiva Muindi, Nici Zimmermann, Susan Michie, Michael Davies   +6 more
doaj   +1 more source

From Clinical Center to Academic Institution: An Example of How to Bring About Educational Change

Health Professions Education, 2015
Background: The usual scenario for change management in the medical education field is an academic institution creating a patient care facility. The opposite change is however rather rare and challenging.
Hanan M. Al-Kadri, Ibrahim A. Al Alwan, Mohamed S. Al-Moamary, Youssef A. Al Eissa, Bandar A. Al Knawy   +4 more
doaj   +1 more source