Results 91 to 100 of about 701,993 (266)

Epigenetic reprogramming of lineage switching in cancer

FEBS Letters, EarlyView.
Cancer cells rarely commit to a single identity. Epigenetic mechanisms and tumor microenvironment cues push epithelial cells toward flexible, hybrid states that can shift into mesenchymal, neuroendocrine, or stem‐like fates, driving metastasis, drug resistance, and tumor heterogeneity. Targeting the epigenetic regulators behind these transitions, using
Ezgi Boyvatlı, Burcu Akman, Ezgi Bağırsakçı, Nese Atabey, Serap Erkek‐Ozhan   +4 more
wiley   +1 more source

The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers

Molecular Oncology, EarlyView.
The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce, Simone Bini, Marialuisa Sponziello, Giorgio Grani, Giulia Fiscon, Paola Paci, Lorenzo Farina, Rosa Falcone, Valentina Maggisano, Sebastiano Filetti, Cosimo Durante, Antonella Verrienti   +11 more
wiley   +1 more source

Can ChatGPT Support Clinical Coding Using the ICD-10-CM/PCS?

Informatics
Introduction: With the growing development and adoption of artificial intelligence in healthcare and across other sectors of society, various user-friendly and engaging tools to support research have emerged, such as chatbots, notably ChatGPT. Objective:
Bernardo Nascimento Teixeira, Ana Leitão, Generosa Nascimento, Adalberto Campos-Fernandes, Francisco Cercas   +4 more
doaj   +1 more source

Circular RNA expression landscapes in myelodysplastic neoplasms: Associations with mutational signatures and disease progression

Molecular Oncology, EarlyView.
In this explorative study, the abundance of circular RNA molecules in bone marrow stem cells was found to be elevated in patients with high‐risk myelodysplastic neoplasms, and to be associated with an increased risk of progression to acute myeloid leukemia.
Eileen Wedge, Morten Tulstrup, Gabriele Todisco, Pedro Moura, Christophe Côme, Jakob Werner Hansen, Jakob Schmidt Jespersen, Balthasar Schlotmann, Maria Creignou, Mette Dahl, Claudia Schöllkopf, Klas Raaschou‐Jensen, Krister Wennerberg, Bo Porse, Joachim Weischenfeldt, Eva Hellström‐Lindberg, Lasse Sommer Kristensen, Kirsten Grønbæk   +17 more
wiley   +1 more source

Towards consensus: The need for standardised definitions in Long (post) COVID care in 34 European countries

European Journal of General Practice
Background The COVID-19 pandemic has significantly impacted global healthcare systems, leading to challenges in managing Long COVID. Variations in definitions and diagnostic criteria across Europe hinder recognition and treatment efforts. This study aims
Raquel Gomez-Bravo, Sandra León-Herrera, Marina Guisado-Clavero, Ileana Gefaell, Xenia Wostmann, Nathalie Wössner, Shlomo Vinker, Francesca Vassallo La Ferla, Erva Kırkoç Üçüncü, Georgi Tsigarovski, Péter Torzsa, Kadri Suija, Aleksander Stepanović, Theresa Sentker, Anna Segernäs, Bohumil Seifert, Marta Sánchez-Castro, Jochen G. Schneider, Anna Repovská, Ferdinando Petrazzuoli, Davorina Petek, Abel Perjes, Naldy Parodi López, Ana Luisa Neves, Katarzyna Nessler, Jean Muris, Achim Mortsiefer, Sarah Moreels, Tatjana Meister, Pekka Mäntyselkä, Liubovė Murauskienė, Heidrun Lingner, Anna Krztoń-Królewiecka, Milena Kostic, Büsra Çimen Korkmaz, Snezana Knezevic, Stylianos Kazakos, Vasilis Karathanos, Ivanna Shushman, Oksana Ilkov, Kathryn Hoffmann, Bruno Heleno, Miroslav Hanževački, Dragan Gjorgjievski, Thomas Frese, Marta Fournier, Louise Fitzgerald, Sabīne Feldmane, Marina Dotsenko, Philip-Richard Domeyer, Daniel Croucher, Vojtech Cerny, Jako S. Burgers, Elena Brutskaya-Stempkovskaya, Carmen Iliana Busneag, Nicola Buono, Sherihane Bensemmane, Sabine Bayen, Maria Bakola, Radost Assenova, Limor Adler, Sara Ares-Blanco, María Pilar Astier-Peña   +62 more
doaj   +1 more source

Keratin 19 as a prognostic marker and contributing factor of metastasis and chemoresistance in high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch, Isabel Vogel, Sina Nokodian, Johanna Moeller, Antonia Blechschmidt, Vicky Hecht, Vanessa Kuentzel, Katharina Thiedig, Melissa Schwab, Oliver Schilling, Holger Bronger, Marion Kiechle, Viktor Magdolen, Tobias Dreyer   +13 more
wiley   +1 more source

CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3

Molecular Oncology, EarlyView.
PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh, Nitzan Medina‐Itzhaki, Milena Chekov, Eden Gal‐Swisa, Roba Gabesh‐Wahabi, Inbar Savyon, Inna Naroditsky, Hilary A. Kenny, Basem Fares, Lina Korsensky, Einav Girsh, Liron Berger, Ruth Perets   +12 more
wiley   +1 more source

Transcriptional profiling of circulating extracellular vesicles from prebiopsy prostate cancer patients

Molecular Oncology, EarlyView.
RNA profiling of circulating extracellular vesicles (EVs) from blood samples of men undergoing prostate biopsy identifies transcripts associated with clinically significant prostate cancer. Integrative analysis with public tumor datasets links EV‐derived gene signatures to tumor stage and progression‐free survival, highlighting CASP3, XRCC2, and RIT1 ...
Stefan Werner, Pierre Tennstedt, Randi C. Pose, Christian Müller, Katharina Besler, Svenja Schneegans, Malik Alawi, Marie C. Roesch, Sven Peine, Desiree Bonci, Joanna Budna‐Tukan, Evi Lianidou, Catherine Alix‐Panabières, Derya Tilki, Klaus Pantel   +14 more
wiley   +1 more source

Dementia Data for People Living in Care Homes: Cross-sectoral National Data Linkage Study of Care Home, Healthcare and Administrative Data Sources

International Journal of Population Data Science
Introduction Dementia is common among people living in care homes, but many residents lack a diagnosis. Quantifying the prevalence of dementia in care homes is therefore challenging.
Kalliopi Mavromati, Maria Drelciuc, Ellen Lynch, Sophie A Hay, Peter Hanlon, Terry J Quinn, Jennifer Kirsty Burton   +6 more
doaj   +1 more source

Automated clinical coding: what, why, and where we are? [PDF]

NPJ Digit Med, 2022
Dong H, Falis M, Whiteley W, Alex B, Matterson J, Ji S, Chen J, Wu H.   +7 more
europepmc   +1 more source