Results 91 to 100 of about 201,869 (314)

Rational Design of Unsaturated, Thioether Ionizable Lipids for Enhanced In Vivo mRNA Delivery

Advanced Healthcare Materials, EarlyView.
Lipid nanoparticles (LNPs) have rapidly become the delivery system of choice for RNA therapeutics. Here, a rational design approach is taken to improve the effectiveness of LNPs based on an ionizable thioether lipid library. The incorporation of unsaturated tails and bulkier, hydrophobic head groups significantly enhances their functionality and ...
Eleni Samaridou, Johanna Simon, Moritz Beck‐Broichsitter, Gary Davidson, Pavel A. Levkin   +4 more
wiley   +1 more source

Nano‐Octahedron Cobalt Oxide Decorated Graphene Nanocomposites for the Selective/Simultaneous Detection of Dopamine

Advanced Materials Interfaces, EarlyView.
Nano‐octahedron Co3O4 decorated graphene composite electrode for selective and simultaneous detection of dopamine. The detection limit of 0.09 µM, and linear range from 1 to 500 µM are reported. The synergistic effect of nano octahedron Co3O4 and graphene results in excellent performance of the sensor in terms of selectivity and sensitivity.
Swathi Tharani Dharmalingam, Mushtaq Ahmad Dar, Rukhsana Gul, Manickam Minakshi Sundaram, Ibrahim Abdullah Alnaser, R. Sivasubramanian   +5 more
wiley   +1 more source

Expanding the clinical spectrum associated with the PACS1 p.Arg203Trp mutational hot‐spot: Two additional Italian patients

, 2023
American Journal of Medical Genetics Part A, Volume 191, Issue 1, Page 284-288, January 2023.
Lucia Pia Bruno, Gabriella Doddato, Margherita Baldassarri, Caterina Lo Rizzo, Sara Resciniti, Mirella Bruttini, Lista Mirjam, Kristina Zguro, Simone Furini, Maria Antonietta Mencarelli, Alessandra Renieri, Francesca Ariani   +11 more
wiley   +1 more source

Identifying roles of clinical pharmacy with survey evaluation [PDF]

arXiv, 2014
The survey data sets are important sources of data and their successful exploitation is of key importance for informed policy-decision making. We present how a survey analysis approach initially developed for customer satisfaction research in marketing can be adapted for the introduction of clinical pharmacy services into hospital.
arxiv  

Ammonia Dynamics in the Human Body: Insights in Biomedical Sensing Technologies

Advanced Sensor Research, EarlyView.
Ammonia (NH3) is a significant biomarker in diagnostics, affecting the respiratory system, stomach, liver, kidneys, bladder, and gastrointestinal tract. NH3 detection, using sensors, has the potential to improve medical diagnosis. This review examines recent advancements in NH3 sensing technologies and explores future research directions, including ...
Annelot Nijkoops, Manuela Ciocca, Martina Aurora Costa Angeli, Silvia Pogliaghi, Soufiane Krik, Enrico Avancini, Niko Münzenrieder, Paolo Lugli, Luisa Petti   +8 more
wiley   +1 more source

A Bayesian Joint model for Longitudinal DAS28 Scores and Competing Risk Informative Drop Out in a Rheumatoid Arthritis Clinical Trial [PDF]

arXiv, 2018
Rheumatoid arthritis clinical trials are strategically designed to collect the disease activity score of each patient over multiple clinical visits, meanwhile a patient may drop out before their intended completion due to various reasons. The dropout terminates the longitudinal data collection on the patients activity score.
arxiv  

FUS Selectively Facilitates circRNAs Packing into Small Extracellular Vesicles within Hypoxia Neuron

Advanced Science, EarlyView.
This study aimed to unravel the role of FUS in the loading of functional circRNAs into neuronal sEVs under hypoxic conditions, which involves their aggregations in SGs and specific interaction between the FUS Zf_RanBP domain to regulate circRNA sorting in sEVs.
Jiankun Zang, Yousheng Wu, Xuanlin Su, Kaiwei Cai, Man Ke, Niu He, Huili Zhu, Zefeng Tan, Jielin Zhu, Wensheng He, Min Peng, Shiqing Zhang, Hongcheng Mai, Anding Xu, Dan Lu   +14 more
wiley   +1 more source

Post-simulation debriefing as a stepping stone to self-reflection and increased awareness — a qualitative study

Advances in Simulation
Background The voice of the students should be engaged in simulation curriculum development. Involving the students in the development of debriefing strategies might result in a deeper understanding of learning. However, few studies have investigated the
Sissel Eikeland Husebø, Inger Åse Reierson, Anette Hansen, Hilde Solli   +3 more
doaj   +1 more source

GRP78 Nanobody‐Directed Immunotoxin Activates Innate Immunity Through STING Pathway to Synergize Tumor Immunotherapy

Advanced Science, EarlyView.
A GRP78 nanobody‐directed immunotoxin suppresses cancer progression and metastasis by enhancing antitumor immunity via STING pathway activation, offering a pan‐cancer‐targeted approach and immunotherapy combination strategy. Abstract The lack of targetable antigens poses a significant challenge in developing effective cancer‐targeted therapies.
Huifang Wang, Runhua Zhou, Chengchao Xu, Lingyun Dai, Rui Hou, Liuhai Zheng, Chunjin Fu, Guangwei Shi, Jingwei Wang, Yang Li, Jinpeng Cen, Xiaolong Xu, Le Yu, Yilei Li, Jigang Wang, Qingfeng Du, Zhijie Li   +16 more
wiley   +1 more source

Men's Behaviour Change Program: Participants' and Facilitators' Perceptions

Australian and New Zealand Journal of Family Therapy, Volume 43, Issue 4, Page 412-422, December 2022., 2022
Men's behaviour change programs (MBCPs) are group programs for men using family violence. This preliminary evaluation examines participants' and facilitators' perceptions of a redeveloped MBCP. Participants reported significant improvements in their ability to manage stress, understand the impact of their use of violence, and apply skills to repair the
Amanda O'Connor, Anastasia Panayiotidis, Andrew Bickerdike, Sandra Opoku, Helen Skouteris   +4 more
wiley   +1 more source