Results 141 to 150 of about 579,638 (359)
An Engineered Soluble Single‐Chain TCR Engager for KRAS‐G12V Specific Tumor Immunotherapy
Advanced Science, EarlyView.This study develops a dimeric T cell receptor engager protein specific for tumor KRAS‐G12V mutation. The engager proteins are capable of mediating the formation of synapse between T cell and tumor cell and demonstrate substantial tumor suppression efficacy.
Keke Ma +14 more
wiley +1 more source
Advanced Science, EarlyView.A phosphorothioate‐modified aptamer PTf‐SRiApt capable of disrupting “undruggable” transcription factor SCAF4‐POLR2A interaction with high inhibitory activity and biological stability is presented here. Through this inhibition, PTf‐SRiApt successfully arrested cell cycle progression, induced cell death, and elevated immune recruitment in SCAF4‐POLR2A ...
Liyan Fei +13 more
wiley +1 more source
Assessment of Practice in Pre-Registration Undergraduate Nursing Programmes. Phase 2 Evaluation: Survey of students’ and mentors’ experiences of grading student competence in practice. [PDF]
, 2009 Executive Summary Context Local and national concerns regarding competency in newly qualified practitioners provided the impetus for the undergraduate nursing programme team at Bournemouth University to radically change the practice assessment tool as ...
Cooper, K. +3 more
core
Approaching Consensus in Clinical Competence Assessment [PDF]
, 2001 Vinette Cross
openalex +1 more source
Advanced Science, EarlyView.The DNA demethylase TET3 drives lipid metabolic reprogramming in pancreatic ductal adenocarcinoma via a non‐catalytic mechanism. TET3 recruits histone deacetylases to repress GATA6, sustaining lipogenic enzyme expression and ferroptosis resistance.
Shuai Liu +8 more
wiley +1 more source
A Complementarity‐Based Approach to De Novo Binder Design
Advanced Science, EarlyView.A novel method for surface complementarity detection (HECTOR) enables highly efficient docking and design of protein interfaces. Applied to therapeutically relevant targets, this method yields de novo binders with potent antagonistic activity. As a first‐principles approach, HECTOR offers a training‐free solution to the binder design problem and is ...
Kateryna Maksymenko +17 more
wiley +1 more source
Advanced Science, EarlyView.The existence of Pin1 and Notch1 crosstalk is identified and verified in HCC, and the crucial function of this crosstalk in sustaining the aggressive phenotypes of CSCs and radioresistance. A biomimetic nanovesicle is now developed to block the crosstalk between Pin1 and Notch1 for inducing CSCs differentiation and sensitizing HCC radiotherapy ...
Hongmei Cao +9 more
wiley +1 more source
Improving support for doctors in the UK : the development of a modified physician assistant model in primary care and internal medicine [PDF]
, 2006 In the United Kingdom, there has been a demand over the last few years to increase the workforce in both primary and secondary care to meet the requirements of the government's ambitious plan for the National Health Service.
Lakhani, Mayur, Sparrow, Nigel
core
Relationships between clinical competence ratings and examination performance
, 1976 Fred J. Dowaliby, Barbara J. Andrew
openalex +1 more source
American College of Cardiology/American Heart Association Clinical Competence Statement on Echocardiography [PDF]
, 2003 Miguel A. Quiñones +20 more
openalex +1 more source