Results 141 to 150 of about 13,627,543 (246)

ADP‐ribosylation: An emerging regulator of the epigenome

Molecular Oncology, EarlyView.
ADP‐ribosylation has emerged as a dynamic epigenetic signaling mechanism that modifies histones and chromatin‐associated proteins. Through coordinated PARylation and MARylation, it integrates with other histone modifications to regulate chromatin structure, transcription factor activity, and gene expression, influencing genome function and disease ...
Cristel V. Camacho, Chenqian Liu, W. Lee Kraus   +2 more
wiley   +1 more source

Download Complete Issue: 43 (100MB)

, 2002
Issue, Complete
core   +1 more source

The Pharmacological Management of Cancer Pain in Adults Clinical Audit Tool

, 2016
The audit standards are based on the Pharmacological Management of Cancer Pain in Adults NCEC National Clinical Guideline No. 9. In developing this tool consideration has been given to the clinical issues covered by the guideline and the potential ...
National Clinical Programme for Palliative Care
core  

Castration‐resistant prostate cancer cells are addicted to the high activity of cyclin‐dependent kinase 2

Molecular Oncology, EarlyView.
We show that emergence of castration‐resistant prostate (CRPC) is associated with significant upregulation of cyclins that positively regulate cyclin‐dependent kinase 2 (CDK2) and concomitant downregulation of CDK4 cyclins. This renders CRPC cells dependent on the high activity of CDK2, and CDK2 inhibitors synergistically sensitize CRPC cells to both ...
Joyeeta Chatterjee, Alessia Marin, Shivani Yalala, Harri M. Itkonen   +3 more
wiley   +1 more source

Development of a Patient Decision Aid for Rectal Cancer Patients with Clinical Complete Response after Neo-Adjuvant Treatment. [PDF]

Cancers (Basel), 2023
Smets L, Debucquoy A, Oldenburger E, Van Audenhove C, Debrun L, Dekervel J, Bislenghi G, D'Hoore A, Wolthuis A, Haustermans K.   +9 more
europepmc   +1 more source

Download the Complete Issue (13.6MB)

, 2015
Issue, Complete
core   +1 more source

Clinical complete response as a surrogate for pathological response in bladder cancer: a systematic review and meta-analysis. [PDF]

BJU Int
Roessler N, Miszczyk M, Gontero P, Dematteis A, Miyajima K, Inoue S, Oberneder K, von Deimling M, Schuettfort VM, Vetterlein MW, Szabados B, Rajwa P, Karakiewicz PI, Teoh JY, Fisch M, Shariat SF.   +15 more
europepmc   +1 more source

Partial FAK suppression promotes tumor growth, an effect reversed by macrophage p110δ PI3K inactivation

Molecular Oncology, EarlyView.
Partial inhibition of focal adhesion kinase (FAK) can paradoxically promote tumor growth, rather than simply producing a weaker antitumor effect than that observed with strong FAK suppression. In breast cancer and melanoma models, targeting p110δ PI3K, particularly in macrophages, counteracted these tumor‐promoting effects, highlighting the importance ...
Lydia Xenou, Niki Tzenaki, Anna Tsapara, Maria Tzardi, Evangelia A. Papakonstanti   +4 more
wiley   +1 more source

Download the Complete Issue (23MB)

, 2016
Issue, Complete
core   +1 more source

Case Report: rapid clinical complete response to Iparomlimab and Tuvonralimab combined with radiotherapy and chemotherapy in a patient with MSS/pMMR locally advanced rectal cancer. [PDF]

Front Oncol
Wang J, Yang T, Zhou J, Chen W, Wang G, Mei C, Chen Z, Li J, Shen T.   +8 more
europepmc   +1 more source