Results 31 to 40 of about 13,627,543 (246)

Evidence‐Informed Multidisciplinary Consensus Guidance for the Psychosocial Care of Adolescents With High‐Risk Cancer: Recommendations From the Italian Association of Pediatric Hematology and Oncology

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Adolescents with high‐risk cancer face complex developmental, psychosocial, and ethical challenges that extend beyond disease‐directed treatment. Although international recommendations exist for communication, psychosocial care, pediatric palliative care, survivorship, and shared decision‐making, these have largely evolved within ...
Johanna M. C. Blom, Dorella Scarponi, Giulia Zucchetti, Teresa Perillo, Maria Montanaro, Elisa Marconi, Chiara Rutigliano, Paolo Colavero, Paola Quarello, Marina Bertolotti, Monica Cellini, Carlo Clerici, Maurizio Mascarin, Francesca Bomben, Andrea Ferrari, the expert workgroup   +15 more
wiley   +1 more source

Neoadjuvant FOLFOXIRI prior to chemoradiotherapy for high-risk (“ugly”) locally advanced rectal cancer: study protocol of a single-arm, multicentre, open-label, phase II trial (MEND-IT)

BMC Cancer, 2022
Background The presence of mesorectal fascia (MRF) invasion, grade 4 extramural venous invasion (EMVI), tumour deposits (TD) or extensive or bilateral extramesorectal (lateral) lymph nodes (LLN) on MRI has been suggested to identify patients with ...
K. van den Berg, D. P. Schaap, E. L. K. Voogt, T. E. Buffart, H. M. W. Verheul, J. W. B. de Groot, C. Verhoef, J. Melenhorst, J. M. L. Roodhart, J. H. W. de Wilt, H. L. van Westreenen, A. G. J. Aalbers, M. van ‘t Veer, C. A. M. Marijnen, J. Vincent, L. H. J. Simkens, N. A. J. B. Peters, M. Berbée, I. M. Werter, P. Snaebjornsson, H. M. U. Peulen, I. G. van Lijnschoten, M. J. Roef, G. A. P. Nieuwenhuijzen, J. G. Bloemen, J. M. W. E. Willems, G. J. M. Creemers, J. Nederend, H. J. T. Rutten, J. W. A. Burger   +29 more
doaj   +1 more source

Bridging the Loneliness Gap: Depression, Connectivity, and Isolation in Pediatric Oncology Patients and Their Peers

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Loneliness is associated with adverse physical and mental health outcomes and remains understudied in children and adolescents undergoing cancer therapy. Pediatric oncology patients may be at increased risk due to medical isolation and disruption of social networks.
Charlotte N. Stahlfeld, Scott H. Maurer, Michelle D. Watkinson, John Nury, Elise Barberis, Molly C. Mack   +5 more
wiley   +1 more source

Programmed death-ligand 1 expression and response to the anti-programmed death 1 antibody pembrolizumab in melanoma [PDF]

, 2016
Purpose: Expression of programmed death-ligand 1 (PD-L1) is a potential predictive marker for response and outcome after treatment with anti–programmed death 1 (PD-1).
Dronca, Roxana, Hodi, F. Stephen, Ribas, Antoni, Zarour, Hassane, Hamid, Omid, Dolled-Filhart, Marisa, Patnaik, Amita, Hersey, Peter, Kang, S. Peter, Daud, Adil I, Gangadhar, Tara C, Emancipator, Kenneth, Li, Xiaoyun Nicole, Weber, Jeffrey S, Kang, S Peter, Lunceford, Jared K, Joshua, Anthony M, Robert, Caroline, Roach, Charlotte, Joseph, Richard, Hodi, F Stephen, Hwu, Wen-Jen, Wolchok, Jedd D, Kefford, Richard, Ebbinghaus, Scot, Toland, Grant   +25 more
core   +1 more source

Early Body Mass Index z‐Score Change and Resolution of Severe Malnutrition in Children With Sickle Cell Anemia in a Low‐Income Setting: A Prospective Single‐Arm Extension Study

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Children with sickle cell anemia (SCA) in low‐income settings are at risk of severe malnutrition, but optimal nutritional management has not been established. We evaluated an intensified ready‐to‐use therapeutic food (RUTF) regimen in children with persistent severe malnutrition after initial treatment and assessed whether early ...
Safiya Gambo, Shehu Umar Abdullahi, Hassan Adam Murtala, Halima Kabir, Khadija A. Shamsu, Sari A. Acra, Virginia A. Stallings, Mark Rodeghier, Michael R. DeBaun, Lauren J. Klein   +9 more
wiley   +1 more source

Comparative Drug Response Profiling in Neuroblastoma Cell Lines and Patient‐Derived Tumor Organoids

Pediatric Blood &Cancer, EarlyView.
ABSTRACT High‐risk neuroblastoma remains a leading cause of pediatric cancer mortality, and improved preclinical models are needed to guide therapeutic developments. We screened seven high‐risk neuroblastoma cell lines and three patient‐derived tumor organoids with 528 compounds alongside bone marrow controls, and compared them with external datasets ...
Krzysztof Wierbiłowicz, Se Whee Sammy Park, Aironas Los, Ernest Liu, Nona Struyf, Tom Erkers, Sören Lehmann, Jan J. Molenaar, Jakob Stenman, Olli Kallioniemi, Päivi Östling, Brinton Seashore‐Ludlow, Kasper Karlsson   +12 more
wiley   +1 more source

Application of artificial intelligence in the assessment of clinical complete response after neoadjuvant therapy for rectal cancer

结直肠肛门外科
Preoperative neoadjuvant therapy has become the standard regimen in the comprehensive management of locally advanced rectal cancer. After neoadjuvant therapy, some patients achieve a state of clinical complete response (cCR) , providing an important ...
Li Shengsheng, Guo Yuchen
doaj   +1 more source

Impact of Radiation Therapy on Physical and Psychosocial Health of Adolescents and Young Adults: A Joint Report From the Children's Oncology Group AYA and Radiation Oncology Committees

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Rates of cancer among adolescents and young adults (AYA), age 15–39 years, are increasing. Consequently, radiation oncologists are treating more AYAs who have diagnoses spanning both pediatric and adult practices. Compared to pediatric and older adult patients, AYAs face a unique set of challenges.
Hesham Elhalawani, Rachel K. Peterson, Avani D. Rao, Laurie J. McKenzie, Ahmed Magdy Elmotayam, Leslie Chang, Michael Roth, Susan L. McGovern   +7 more
wiley   +1 more source

Small bowel metastasis during organ preservation in patients with esophageal squamous cell carcinoma: case report and literature review

Frontiers in Oncology
BackgroundFor patients with locally advanced esophageal squamous cell carcinoma (ESCC) who achieve a clinical complete response (cCR) after comprehensive treatment, organ preservation and observation-waiting strategies provide a more conservative ...
Qinxing Cao, Qinxing Cao, Hejiang Lu, Hejiang Lu, Liangbo Niu, Xiaofang Zhao, Li Yan, Yisha Liu, Minghui Pang, Minghui Pang   +9 more
doaj   +1 more source

Utility of rectoscopy in the assessment of response to neoadjuvant treatment for locally advanced rectal cancer

The Saudi Journal of Gastroenterology, 2016
Background/Aims: The management of locally advanced rectal cancer has changed substantially over the last few decades with neoadjuvant chemoradiotherapy. The aim of the present study is to compare the results between neoadjuvant post-treatment rectoscopy
Victor Lopez-Lopez, Jesus Abrisqueta, Juan Lujan, Quiteria Hernandez, Akiko Ono, Pascual Parrilla   +5 more
doaj   +1 more source