Results 191 to 200 of about 1,059,545 (258)

Reprogramming tumor cells with LCOR mRNA nanotherapy to enhance immunotherapy

Molecular Oncology, EarlyView.
LCOR (Ligand‐dependent corepressor) mRNA encapsulated in polymeric nanoparticles restores LCOR activity in tumor cells, constraining aggressive tumor cell states and increasing tumor immunogenicity. This reprogramming makes tumor cells more vulnerable to T‐cell attack and enhances their response to immune‐checkpoint immunotherapy.
Gabriel Serra‐Mir, Elena Haro‐Martínez, Sandra Blasco‐Benito, Chiara Cannatà, José Ángel Palomeque, Anna López‐Plana, Maria Sanz‐Flores, Marc Sabartés, Cristina Fornaguera, Toni Celià‐Terrassa   +9 more
wiley   +1 more source

The association between nurses' personality types and attitudes towards older patients and their clinical decision-making styles. [PDF]

BMC Nurs
Salarvand S, Ajamian M, Goodarzi E.
europepmc   +1 more source

Optimization of seminal extracellular vesicle isolation protocols for cancer biomarker analysis using proteomic profiling

Molecular Oncology, EarlyView.
This paper shows that size‐exclusion chromatography and sequential centrifugation applied to seminal plasma enrich for different populations of extracellular vesicles. This may significantly affect the detection and analysis of extracellular vesicle‐associated cancer biomarkers.
Elen Telumyan, Beatriz Martín‐Gracia, Eva Bassols‐Citores, Krizia Sagini, Maria K. Andersen, Tuula A. Nyman, May‐Britt Tessem, Morten B. Rye, Alicia Llorente   +8 more
wiley   +1 more source

The first 72 hours of acute pancreatitis: patterns of variability in early clinical decision-making. [PDF]

World J Emerg Surg
Rodrigo Rodrigo M, Gómez Vallvé N, López Gordo S, González-Castillo AM, Pavel M, Llàcer E, Estalella L, Guerrero MA, Memba R, Jorba I Martín R, Ramírez-Maldonado E.   +10 more
europepmc   +1 more source

Engineering IL‐4 resistant proinflammatory human myeloid cells for cancer immunotherapy

Molecular Oncology, EarlyView.
We developed a scalable workflow to generate proinflammatory human myeloid cells. CRISPR/Cas9‐edited CD34+ hematopoietic stem and progenitor cells were expanded and differentiated with M‐CSF. Deletion of STAT6 or STAT6/NFKB1 enhanced macrophage proinflammatory gene expression and cytokine secretion in the presence of IL‐4 while maintaining antibody ...
Theresa Barberi, Alan D. Friedman
wiley   +1 more source

Correction to "Emergency Department Crowding and Diagnostic Safety: An Underrecognized Risk to Clinical Decision Making". [PDF]

J Am Coll Emerg Physicians Open
europepmc   +1 more source

The use of albuminuria and proteinuria for regulatory clinical decision making: a perspective from European regulators. [PDF]

Nephrol Dial Transplant
Holtkamp F, Gudmundsdottir H, van Doorn KJ, Vetter T.   +3 more
europepmc   +1 more source

Non-Invasive Assessment of Coronary Microvascular Dysfunction: From Flow Quantification to Clinical Decision Making. [PDF]

Medicina (Kaunas)
Theofilis P, Sakalidis A, Dimitriadis K, Karakasis P, Papanikolaou A, Iliakis P, Vordoni A, Vlachakis PK, Tsioufis P, Adamopoulou E, Panoulas V, Aznaouridis K, Tsioufis K, Tousoulis D.   +13 more
europepmc   +1 more source