Results 121 to 130 of about 1,803,951 (318)

A Clinical Decision-Support System Based on Three-Stage Integrated Image Analysis for Diagnosing Lung Disease [PDF]

, 2020
Ching‐Hsue Cheng, Hsien-Hsiu Chen, Tai-Liang Chen   +2 more
openalex   +1 more source

Capture and Reuse of Knowledge in ICT-based Decisional Environments [PDF]

Health care practitioners continually confront with a wide range of challenges, seeking to making difficult diagnoses, avoiding errors, ensuring highest quality, maximizing efficacy and reducing costs.
Florin Gheorghe FILIP, Ioana Andreea STANESCU   +1 more
core  

A clinician-mediated, longitudinal tracking system for the follow-up of clinical results [PDF]

, 2005
Thesis (S.M.)--Harvard-MIT Division of Health Sciences and Technology, 2005.Includes bibliographical references (p. 36-37).Failure to follow-up on abnormal tests is a common clinical concern comprising the quality of care.
Rosenthal, Daniel Todd
core  

PICALM::MLLT10 translocated leukemia

FEBS Letters, EarlyView.
This comprehensive review of PICALM::MLLT10 translocated acute leukemia provides an in‐depth review of the structure and function of CALM, AF10, and the fusion oncoprotein (1). The multifaceted molecular mechanisms of oncogenesis, including nucleocytoplasmic shuttling (2), epigenetic modifications (3), and disruption of endocytosis (4), are then ...
John M. Cullen, Antonia C. Nakatsugawa, Natalie Barton, Henry Haines, Gary S. Stein, Janet L. Stein, Daniel S. Wechsler, Jessica L. Heath   +7 more
wiley   +1 more source

Cell wall target fragment discovery using a low‐cost, minimal fragment library

FEBS Letters, EarlyView.
LoCoFrag100 is a fragment library made up of 100 different compounds. Similarity between the fragments is minimized and 10 different fragments are mixed into a single cocktail, which is soaked to protein crystals. These crystals are analysed by X‐ray crystallography, revealing the binding modes of the bound fragment ligands.
Kaizhou Yan, Mathew Stanley, Olawale Raimi, Andrew T. Ferenbach, Helge C Dorfmueller, Daan M. F. van Aalten   +5 more
wiley   +1 more source

β‐TrCP overexpression enhances cisplatin sensitivity by depleting BRCA1

Molecular Oncology, EarlyView.
Low levels of β‐TrCP (Panel A) allow the accumulation of BRCA1 and CtIP, which facilitate the repair of cisplatin‐induced DNA damage via homologous recombination (HR) and promote tumor cell survival. In contrast, high β‐TrCP expression (Panel B) leads to BRCA1 and CtIP degradation, impairing HR repair, resulting in persistent DNA damage and apoptosis ...
Rocío Jiménez‐Guerrero, Alejandro Belmonte‐Fernández, Mónica González‐Moreno, Laura Rodríguez‐Cordero, Begoña Pérez‐Valderrama, Joaquín Herrero‐Ruíz, Francisco Romero, Carmen Sáez, Miguel Á. Japón   +8 more
wiley   +1 more source

Clinical Decision Support Systems [PDF]

, 2011
Dinevski, Dejan, Bele, Uroš, Šarenac, Tomislav, Rajkovič, Uroš, Šušteršič, Olga   +4 more
openaire   +4 more sources

AI-based algorithm for clinical decision support system in colonoscopy

, 2023
Д. А. Мтвралашвили, Д. Г. Шахматов, А. А. Ликутов, A. G. Zapolsky, D. I. Suslova, Aleksandr Borodinov, О. И. Сушков, С. И. Ачкасов   +7 more
openalex   +2 more sources

Nicotinamide N‐methyltransferase promotes drug resistance in lung cancer, as revealed by nascent proteomic profiling

Molecular Oncology, EarlyView.
AZD9291 has shown promise in targeted cancer therapy but is limited by resistance. In this study, we employed metabolic labeling and LC–MS/MS to profile time‐resolved nascent protein perturbations, allowing dynamic tracking of drug‐responsive proteins. We demonstrated that increased NNMT expression is associated with drug resistance, highlighting NNMT ...
Zhanwu Hou, Zhen Wang, Fei Yang, Xiao Han, Lei Li, Huadong Liu   +5 more
wiley   +1 more source

Clinical Decision Support Systems [PDF]

Neurosurgery, 2012
Edie E. Zusman, Yuriy Vinokur
openaire   +2 more sources