Results 121 to 130 of about 28,420,668 (240)

Leucine‐rich glioma inactivated 1 (LGI1) is a ganglioside‐binding protein

FEBS Letters, EarlyView.
Neuronal hyperexcitability associated with a decrease/absence of the extracellular protein LGI1 has been suggested to be primarily due to the downregulation of Kv1 channel expression. The molecular mechanisms underlying this decrease have not yet been elucidated.
Kévin Debreux, Christian Lévêque, Fodil Azzaz, Marion Sangiardi, Sarosh R Irani, Michael Seagar, Jacques Fantini, Oussama El Far   +7 more
wiley   +1 more source

Decision discovery using clinical decision support system decision log data for supporting the nurse decision-making process

BMC Medical Informatics and Decision Making
Background Decision-making in healthcare is increasingly complex; notably in hospital environments where the information density is high, e.g., emergency departments, oncology departments, and psychiatry departments. This study aims to discover decisions
Matthijs Berkhout, Koen Smit, Johan Versendaal   +2 more
doaj   +1 more source

Emotion-Adaptive Large Language Model–Driven Clinical Decision Support: User Evaluation of the Empathic Clinical Decision Support System Framework for Trust and Explainability

JMIR Human Factors
BackgroundThe increasing prevalence of cannabis use has motivated researchers to develop computational behavioral models that predict usage patterns and related health impacts in naturalistic environments.
Tongze Zhang, Sang Won Bae, Tammy Chung, Anind K Dey   +3 more
doaj   +1 more source

A context‐dependent modulatory role for eIF6 in acquired resistance to vemurafenib in melanoma

FEBS Letters, EarlyView.
Acquired resistance to vemurafenib upregulates the translation factor eIF6 in melanoma cells. Silencing eIF6 in resistant cells reduces proliferation and partially restores drug sensitivity, whereas its overexpression increases sensitivity across melanoma lines regardless of BRAF status, via modulation of mTOR, S6K, and MAPK signaling.
George Kyriakopoulos, Antonia Petropoulou, Alexandra Anastogianni, Angelina Bania, Vassilis Stamatakis, Argyris Alexiou, Chi‐Ping Day, Glenn Merlino, Katerina Grafanaki, Constantinos Stathopoulos   +9 more
wiley   +1 more source

Metastatic niche shaped by host factors influences disseminated cancer cell fate

FEBS Letters, EarlyView.
Metastasis is shaped not only by cancer cells but also by the environments they encounter. This review explores how factors such as aging, diet, the microbiome, lifestyle, and environmental exposures remodel organ‐specific niches in the lung, liver, bone, and brain, influencing where metastatic cells survive, remain dormant, or grow, and ultimately ...
Gwennan Delyth Ward, Álvaro Ruiz‐Tabas, Patricia Altea‐Manzano   +2 more
wiley   +1 more source

DECISION SUPPORT SYSTEM FOR MANAGING AND DETERMINING INTERNATIONAL CLASS PROGRAM: GA AND AHP APPROACH [PDF]

, 2010
This study proposes a new method, a hybrid model for managing and determining the proposed International class based on many criteria of academic performance in university.
Jati, Handaru
core  

Smaller is better: nanobodies meet NMR

FEBS Letters, EarlyView.
Nanobodies are single‐domain antigen‐binding fragments derived from camelid heavy chain antibodies. Their small size, high stability, and exceptional specificity make nanobodies uniquely useful probes for NMR studies of protein dynamics, transient conformational states, and protein–protein interactions.
Oleg Y. Dmitriev
wiley   +1 more source

An Artificial Intelligence Driven Clinical Decision Support System for Patient Triage

Engineering Proceedings
The medical triage platform, by integrating clinical and informatics components, aims to optimize patient flow in emergency and outpatient services. Case variability and the need for rapid prioritization can significantly influence medical decisions and ...
Mădălin Geru, Andreea Matei, Flavia-Iuliana Neculai, Andreea-Larisa Țiploiu, Călin Corciovă, Robert Fuior   +5 more
doaj   +1 more source

User-adapted Clinical Decision Support System

, 2005
Clinical Decision Support Systems (CDSSs) have been one of the challenging real-world applications of artificial intelligence techniques for decades. CDSSs built so far mainly deal with explicit medical knowledge, typically encoded into a knowledge base.
Paolo Carli, M. Cristofolini, Cristofolini, Mario, Sboner, Andrea, BELLAZZI, RICCARDO, Carli, Paolo, Riccardo Bellazzi   +6 more
core  

The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers

Molecular Oncology, EarlyView.
The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce, Simone Bini, Marialuisa Sponziello, Giorgio Grani, Giulia Fiscon, Paola Paci, Lorenzo Farina, Rosa Falcone, Valentina Maggisano, Sebastiano Filetti, Cosimo Durante, Antonella Verrienti   +11 more
wiley   +1 more source