Results 121 to 130 of about 931,164 (251)

From mice to humans—divergent strategies for intestinal homeostasis and regeneration

FEBS Letters, EarlyView.
Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa, Shinya Sugimoto, Toshiro Sato   +2 more
wiley   +1 more source

Safety of a large language model-based clinical decision support system in African primary healthcare. [PDF]

Nat Health
Agweyu A, Mwaniki P, Musau W, Korom R, Isaaka L, Wanyama C, Kiptinness S, Adan N, Emmanuel-Fabula M, Mateen BA.   +9 more
europepmc   +1 more source

Phosphoinositides and inositol phosphates as molecular glues

FEBS Letters, EarlyView.
Inositol phosphates (IPs) and phosphoinositides (PIPs) regulate diverse eukaryotic processes. Beyond recruiting signaling proteins or acting as structural cofactors, recent studies suggest they mediate protein–protein interactions as natural molecular glues.
Aleshia Seaton‐Terry, Alexander J. Cutright, Mong Na Claire Loi, Jessica Martin, Joseph W. Gilligan, Jakub N. Kubina, Michael J. Arambula, Susanna Tanada Palmu, Daniella Zhou, Raymond D. Blind   +9 more
wiley   +1 more source

The use of an innovative clinical decision support system focused on psychosocial vulnerabilities during pregnancy: the Born in Belgium Professionals Platform. [PDF]

BMC Health Serv Res
Amuli K, Decabooter K, Germanes C, Van Parys AS, Eerens B, Verschelde S, Saey E, Nihoul M, Moulin M, Cornu P, Delvaux N, Jacobs A, Van den Berghe S, Feijen-de Jong E, Beeckman K.   +14 more
europepmc   +1 more source

Design and analysis strategies for robust microbiome ageing research

FEBS Letters, EarlyView.
The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik, İsmail Güderer, Yi Wang, Tayyaba Alvi, Prasoon Pandey, Handan Melike Dönertaş   +5 more
wiley   +1 more source

User-Centered Redesign of a Clinical Decision Support System for Pneumonia in the Emergency Department. [PDF]

Appl Clin Inform
Christensen MA, Beebe R, Chen A, Reale C, Faiman J, Wrenn JO, Gradwohl SC, Slagle JM, Weitkamp AO, Nance BA, Kuttler KG, Carr JR, Peltan ID, Brown SM, Dean NC, Anders S, Ward MJ.   +16 more
europepmc   +1 more source

Reconstructing enzyme evolution by protein engineering

FEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler, Markus R. Busch, Reinhard Sterner   +2 more
wiley   +1 more source

Effect of a Clinical Decision Support System on Team-Based Clinical Quiz Performance Among Japanese Medical Students: A Pre-Post Pilot Study. [PDF]

J Gen Fam Med
Isoda S, Hashimoto T, Nishizawa T, Sekiya S, Yamanaka S, Misawa M, Watari T, Ueda E, Suzuki T, Tokuda Y.   +9 more
europepmc   +1 more source

Decoding the dynamic extracellular matrix in cancer—3D models and bioscaffolds rewire the rules of tumor progression

FEBS Letters, EarlyView.
Cancer progression is regulated by the dynamic matrix code of the tumor microenvironment, which influences cellular behavior and disease development. Importantly, matrix remodeling in three‐dimensional cancer models more accurately reflects in vivo conditions compared to conventional two‐dimensional systems.
Sylvia Mangani, Konstantinos Spanopoulos, Zoi Piperigkou, Nikos K. Karamanos   +3 more
wiley   +1 more source

Predicting orchiectomy in testicular torsion using hybrid machine learning and explainable AI: a web-based clinical decision support system. [PDF]

World J Urol
Çift A, Kutlu H, Çoban F, Sulhan H, Sever S, Koç MK, Kılınç M, Kalyenci B.   +7 more
europepmc   +1 more source