Results 191 to 200 of about 931,164 (251)

Epigenetic heterogeneity and plasticity in therapy‐induced tumor states through single‐cell multi‐omics

Molecular Oncology, EarlyView.
Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim, Hwiyeong Lee, Jin Hong, Daechan Park   +3 more
wiley   +1 more source

Drug-Induced QT Prolongation: Associations Between Risk Classifications in a Swedish Clinical Decision Support System and Clinical Outcomes. [PDF]

Clin Pharmacol Ther
Nordqvist O, Björneld O, Bergman P, Wettermark B, Lincke A, Andersson ML, Hammar T.   +6 more
europepmc   +1 more source

PAK1 activation drives divergent resistance mechanisms to aromatase inhibition and tamoxifen in a luminal: A breast cancer model

Molecular Oncology, EarlyView.
Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller, Janina Müller, Efstathios‐Iason Vlachavas, Lukas Beumers, Lena Fleischhacker, Sara Burmester, Angelika Wörner, Sabine Karolus, Dominic Helm, Cindy Körner, Stefan Wiemann   +10 more
wiley   +1 more source

Influence of a clinical decision support system on the anticoagulation treatment knowledge, attitude and practice of general practitioners and their using experience: a mixed method study. [PDF]

BMC Prim Care
Ru X, Wang T, Gao J, Yang H, Gao J, Kong B, Yuan G, Yang Q, Ma Y, Pan Z.   +9 more
europepmc   +1 more source

Spatial and single‐nuclei transcriptomics reveals idiosyncratic and generic patterns in papillary and anaplastic thyroid cancers

Molecular Oncology, EarlyView.
Matched spatial transcriptomics and single‐nuclei RNA‐seq were generated for anaplastic and BRAFV600E papillary thyroid cancers revealing generic and tumor‐specific states occurring in cancer cells and in the tumor microenvironment. In this context, cancer dedifferentiation mirrored organoid maturation through ordered thyroid marker gain/loss ...
Adrien Tourneur, Joel Rodrigues Vitória, Manuel Saiselet, Ligia Craciun, Denis Larsimont, Anne Lefort, Frédérick Libert, Carine Maenhaut, Sabine Costagliola, Maxime Tarabichi, Mirian Romitti, Vincent Detours   +11 more
wiley   +1 more source

Commentary on "A preoperative nomogram and web-based clinical decision support system for predicting early renal function after living donor kidney transplantation". [PDF]

Int J Surg
Luo H, Wang Y, Long H.
europepmc   +1 more source

A qualitative interview study to investigate opportunities for improvement in routine asthma care using a clinical decision support system. [PDF]

Sci Rep
Tibble H, Garcia Iglesias J, Chung A.
europepmc   +1 more source

Advancing treat-to-target in SLE: a pilot study using a clinical decision support system. [PDF]

Lupus Sci Med
Parra Sánchez AR, Vos K, van Hall O, Bultink IEM, Tsang-A-Sjoe M, Voskuyl A, van Vollenhoven RF.   +6 more
europepmc   +1 more source

Assessing TDApp: An AI-based clinical decision support system for ADHD treatment recommendations. [PDF]

Front Psychiatry
Baykova E, Raya Ò, Lombardía C, Gonzalvo B, Andreu I, Losada D, Falkenhain T, Cunill R, Serrano D, Rigau D, Ramírez-Saco D, López B, Castells X.   +12 more
europepmc   +1 more source

Visual analysis of research hot topics and trends of clinical decision support system based on CiteSpace. [PDF]

Langenbecks Arch Surg
Wang S, Yu L.
europepmc   +1 more source