Results 201 to 210 of about 935,725 (295)

MOCRA: A multi-algorithm clinical decision support system for the early detection of ovarian cancer. [PDF]

J Ovarian Res
Safaie A, Ghaffari P, Ghaderzadeh M, Salehnasab C.   +3 more
europepmc   +1 more source

Epigenetic heterogeneity and plasticity in therapy‐induced tumor states through single‐cell multi‐omics

Molecular Oncology, EarlyView.
Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim, Hwiyeong Lee, Jin Hong, Daechan Park   +3 more
wiley   +1 more source

Monitoring prostate cancer under androgen-deprivation therapy: insights from the implementation of a clinical decision support system dashboard. [PDF]

Front Oncol
Martínez-Pérez Á, Collantes G, Ruiz-Cerdá JL, Conde-Moreno A, Gironés R, Garcillán B, Amengual J, Gas ME.   +7 more
europepmc   +1 more source

PAK1 activation drives divergent resistance mechanisms to aromatase inhibition and tamoxifen in a luminal: A breast cancer model

Molecular Oncology, EarlyView.
Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller, Janina Müller, Efstathios‐Iason Vlachavas, Lukas Beumers, Lena Fleischhacker, Sara Burmester, Angelika Wörner, Sabine Karolus, Dominic Helm, Cindy Körner, Stefan Wiemann   +10 more
wiley   +1 more source

The use of decision support systems in making strategic decisions in local authorities : a comparative study of Egypt and the UK

The application of a modified Technology Acceptance Model (TAM) to determine the factors affecting the use of Decision Support Systems (DSS) in strategic decisionmaking in local authorities in both the UK and Egypt was the main core of this research ...
Elbeltagi, Ibrahim M.
core  

Policy, Financing, and Regulatory Barriers to Adopting AI-Powered Electrocardiography Interpretation Clinical Decision Support System in Ethiopia: A Qualitative Study. [PDF]

Int J Environ Res Public Health
Boltena MT, El-Khatib Z, Zewdie A, Springer P, Gebremedhn AT, Bukate TA, Fantaye YA, Mekoro M, Shargie MB, Kebede AS.   +9 more
europepmc   +1 more source

ZW4864‐mediated inhibition of the β‐catenin/BCL9/BCL9L complex reveals therapeutic potential in bladder cancer

Molecular Oncology, EarlyView.
BCL9 and BCL9L drive bladder cancer progression by enhancing β‐catenin signaling, promoting proliferation, migration, invasion, and organoid growth. Genetic depletion of BCL9(L) suppresses malignant phenotypes, while pharmacological disruption of the β‐catenin/BCL9(L) complex with ZW4864 inhibits canonical Wnt signaling and tumor‐associated cellular ...
Roland Kotolloshi, Mandy Berndt‐Paetz, Eileen Lerner, Gregoire Najjar, Anca Azoitei, Krishna Pal Singh, Shailendra Kumar Gupta, Olaf Wolkenhauer, Cagatay Günes, Otmar Huber, Marc‐Oliver Grimm, Daniel Steinbach   +11 more
wiley   +1 more source

Utility of a Smartphone-Based Clinical Decision Support System for Pressure Ulcer Management by Physicians: Randomized Crossover Pilot Study. [PDF]

JMIR Form Res
Ito T, Hirosawa T, Hayashi A, Yokose M, Shimizu T.   +4 more
europepmc   +1 more source

Mycobacterial cell division arrest and smooth‐to‐rough envelope transition using CRISPRi‐mediated genetic repression systems

FEBS Open Bio, EarlyView.
CRISPRI‐mediated gene silencing and phenotypic exploration in nontuberculous mycobacteria. In this Research Protocol, we describe approaches to control, monitor, and quantitatively assess CRISPRI‐mediated gene silencing in M. smegmatis and M. abscessus model organisms.
Vanessa Point, Wafaa Achache, Janïs Laudouze, Eliana Sepulveda Ramos, Mickaël Maziero, Céline Crauste, Stéphane Canaan, Pierre Santucci   +7 more
wiley   +1 more source

Application of intensive care information system in clinical decision support

Huli yanjiu, 2016
尉俊铮, 王欣然, 王硕, 翟凤杰, 应波, 韩斌如, 费小璐, 王力红   +7 more
doaj