Results 241 to 250 of about 1,803,951 (318)

Crucial parameters for precise copy number variation detection in formalin‐fixed paraffin‐embedded solid cancer samples

Molecular Oncology, EarlyView.
This study shows that copy number variations (CNVs) can be reliably detected in formalin‐fixed paraffin‐embedded (FFPE) solid cancer samples using ultra‐low‐pass whole‐genome sequencing, provided that key (pre)‐analytical parameters are optimized.
Hanne Goris, Vasiliki Siozopoulou, Léon C van Kempen, Anne Sieben, Ella Roelant, Stig Hellemans, Elyne Backx, Laure Sorber, Koen De Winne, Senada Koljenović, Karen Zwaenepoel   +10 more
wiley   +1 more source

A pilot feasibility study of human-centered design for cirrhosis care: Development and pilot testing of SMARTLiver prototype, a FHIR-based clinical decision support system for hepatology. [PDF]

PLOS Digit Health
Sunchu K, Desai AP, Vuppalanchi R, Purkayastha S.   +3 more
europepmc   +1 more source

Phenotypic and genotypic characterization of single circulating tumor cells in the follow‐up of high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Single circulating tumor cells (sCTCs) from high‐grade serous ovarian cancer patients were enriched, imaged, and genomically profiled using WGA and NGS at different time points during treatment. sCTCs revealed enrichment of alterations in Chromosomes 2, 7, and 12 as well as persistent or emerging oncogenic CNAs, supporting sCTC identity.
Carolin Salmon, Rui P. L. Neves, Nikolas H. Stoecklein, Sven‐Thorsten Liffers, Jens Siveke, Jan D. Kuhlmann, Pauline Wimberger, Paul Buderath, Rainer Kimmig, Sabine Kasimir‐Bauer   +9 more
wiley   +1 more source

Application of intensive care information system in clinical decision support

Huli yanjiu, 2016
尉俊铮, 王欣然, 王硕, 翟凤杰, 应波, 韩斌如, 费小璐, 王力红   +7 more
doaj  

Basic components of a rule⁃driven clinical nursing decision support system:an example of an intelligent delirium nursing clinical decision aid support system

Huli yanjiu, 2022
ZHANG Shan, CUI Wei, WU Ying
doaj  

Cost-effectiveness of a clinical decision support system for atrial fibrillation: an RCT-based modelling study. [PDF]

Eur Heart J Digit Health
Persson Lindell O, Henriksson M, Karlsson LO, Nilsson S, Charitakis E, Janzon M.   +5 more
europepmc   +1 more source

Reducing incorrect antibiotic dosing and enhancing prescriber adherence through a real‐time, patient‐specific clinical decision support system: A post‐implementation evaluation [PDF]

Shiou‐Haur Liang, Cheng‐Loong Liang, Wang‐Chun Chen, Chun‐Kai Huang, Chung‐Hsu Lai, I‐Fan Lin, H K Chang, Yung‐Chia Hsu, Chiu‐Yen Yeh, Pin‐Ru Chang‐Chien, F. Liu, Chia‐Ta Tsai   +11 more
openalex   +1 more source

Combining antibody conjugates with cytotoxic and immune‐stimulating payloads maximizes anti‐cancer activity

Molecular Oncology, EarlyView.
Methods to improve antibody–drug conjugate (ADC) treatment durability in cancer therapy are needed. We utilized ADCs and immune‐stimulating antibody conjugates (ISACs), which are made from two non‐competitive antibodies, to enhance the entry of toxic payloads into cancer cells and deliver immunostimulatory agents into immune cells.
Tiexin Wang, Dong Jun Koo, Peter M. Tessier, Greg M. Thurber   +3 more
wiley   +1 more source

Clinical practice, decision-making, and use of clinical decision support systems in invasive mechanical ventilation: a narrative review [PDF]

Mayur Murali, Melody Ni, Dan Stieper Karbing, Stephen Edward Rees, Matthieu Komorowski, Dominic C. Marshall, Padmanabhan Ramnarayan, Brijesh Patel   +7 more
openalex   +1 more source

Dammarenediol II enhances etoposide‐induced apoptosis by targeting O‐GlcNAc transferase and Akt/GSK3β/mTOR signaling in liver cancer

Molecular Oncology, EarlyView.
Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee, Byung‐Cheol Han, Gi‐Bang Koo, Jihye Park, Mijin Kwon, Young Bin Park, Jae‐Mun Choi, Seung‐Ho Lee, Sangho Roh   +8 more
wiley   +1 more source