Results 191 to 200 of about 584,812 (251)

Inhibition of cyclin‐dependent kinases 12/13 using CT7439 as a treatment for colorectal cancer with CDK12 upregulation

Molecular Oncology, EarlyView.
The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington, Divya L. Dayanidhi, Mohammad Zokaasadi, John B. Mantyh, Pelumi D. Olawuni, Gabrielle Rupprecht, Jeremy M. Force, Shannon McCall, Ashwani K. Bahl, David S. Hsu, Jason A. Somarelli   +10 more
wiley   +1 more source

Evaluating the role of clinical decision support systems in medication safety for older people: a systematic review. [PDF]

Age Ageing
Ng Y, Hsu JTY, Ng NNE, Ong JZE, Hsu JLJ, Sulaimi F, Tan HK, Tang ASP, Ng QX.   +8 more
europepmc   +1 more source

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

Molecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq, Marc Terrones, Felicia Rodrigues Fortes, Anne Schepers, Alessia Denis, Christophe Deben, Ken Op de Beeck, Guy Van Camp, Geert Vandeweyer   +8 more
wiley   +1 more source

Chat GPT vs. Clinical Decision Support Systems in the Analysis of Drug-Drug Interactions. [PDF]

Clin Pharmacol Ther
Bischof T, Al Jalali V, Zeitlinger M, Jorda A, Hana M, Singeorzan KN, Riesenhuber N, Stemer G, Schoergenhofer C.   +8 more
europepmc   +1 more source

ZW4864‐mediated inhibition of the β‐catenin/BCL9/BCL9L complex reveals therapeutic potential in bladder cancer

Molecular Oncology, EarlyView.
BCL9 and BCL9L drive bladder cancer progression by enhancing β‐catenin signaling, promoting proliferation, migration, invasion, and organoid growth. Genetic depletion of BCL9(L) suppresses malignant phenotypes, while pharmacological disruption of the β‐catenin/BCL9(L) complex with ZW4864 inhibits canonical Wnt signaling and tumor‐associated cellular ...
Roland Kotolloshi, Mandy Berndt‐Paetz, Eileen Lerner, Gregoire Najjar, Anca Azoitei, Krishna Pal Singh, Shailendra Kumar Gupta, Olaf Wolkenhauer, Cagatay Günes, Otmar Huber, Marc‐Oliver Grimm, Daniel Steinbach   +11 more
wiley   +1 more source

Impact of clinical decision support systems (CDSS) on clinical outcomes and healthcare delivery in low- and middle-income countries: protocol for a systematic review and meta-analysis. [PDF]

BMJ Open
Jain G, Bodade A, Pati S.
europepmc   +1 more source

Circulating microRNA signatures of cachexia and cancer in Canis familiaris as a comparative oncology model for human disease

Molecular Oncology, EarlyView.
Circulating microRNAs as biomarkers of cachexia and sex‐specific cancer in senior dogs. In 25 client‐owned dogs, four circulating miRNAs (miR‐15a, miR‐15b, miR‐16, miR‐140) were downregulated in cachexia, with miR‐16 the strongest individual biomarker (AUC = 0.899).
Soon‐Seok Park, Kyongman An, Gyeonghwa Kim, Soo‐Nyun Choi, Hong‐Ki Lee, Keun Hur, Kyu‐Shik Jeong   +6 more
wiley   +1 more source

Correction: Adaptive questionnaires for facilitating patient data entry in clinical decision support systems: methods and application to STOPP/ START v2. [PDF]

BMC Med Inform Decis Mak
Lamy JB, Mouazer A, Léguillon R, Lelong R, Darmoni S, Sedki K, Dubois S, Falcoff H.   +7 more
europepmc   +1 more source

Designing Clinical Decision Support Systems (CDSS)-A User-Centered Lens of the Design Characteristics, Challenges, and Implications: Systematic Review. [PDF]

J Med Internet Res
Bayor AA, Li J, Yang IA, Varnfield M.
europepmc   +1 more source

Digitization in nursing processes and the use of clinical decision support systems: do they improve perinatal indicators? [PDF]

BMC Pregnancy Childbirth
Özkan A, Acar Z.
europepmc   +1 more source