Results 171 to 180 of about 677,579 (283)

Intracranial haemorrhage without early clinical deterioration after mechanical thrombectomy: rethinking the "asymptomatic" label. [PDF]

Eur Stroke J
Riegler C, Nolte CH, von Rennenberg R, Bollweg K, Hahn M, Uphaus T, Alegiani A, Illies T, Wischmann J, Kellert L, Bernkopf K, Wunderlich S, Hennersdorf F, Poli S, Mann L, Keil F, Jamous A, Ernst MS, Bürkle F, Wiesmann M, Akkurt B, Faizy T, Audebert HJ, Wattjes MP, Siebert E, Nawabi J.   +25 more
europepmc   +1 more source

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source

Assessing Clinical Deterioration in Children With Dark-Coloured Skin: A Scoping Review. [PDF]

J Clin Nurs
Kelly C, Leslie GD, Laird P, Stokes S, Gill FJ.   +4 more
europepmc   +1 more source

Pancreatic transplantation using duct occlusion technique [PDF]

, 1988
Abendroth, D., Illner, Wolf-Dieter, Land, Walter, Landgraf, R.   +3 more
core   +1 more source

E2A selectively regulates TGF‐β–induced apoptosis in KRAS‐mutant non‐small cell lung cancer

Molecular Oncology, EarlyView.
Ability to induce apoptosis by TGF‐β is frequently lost in advanced lung adenocarcinoma despite intact TGF‐β signaling. We identify E2A as a mutant KRAS–dependent mediator of resistance to TGF‐β–induced apoptosis. TGF‐β induces E2A via SMAD3 in mutant KRAS cells, and E2A silencing restores apoptosis and enhances radiation response in cell lines ...
Sergei Chuikov, Shiva Krishna Katkam, Zhefan Wang, Venkateshwar G. Keshamouni   +3 more
wiley   +1 more source

Analysis of Influencing Factors of Junior ICU Nurses' Recognition and Response Abilities to Clinical Deterioration: A Cross-Sectional Study. [PDF]

Crit Care Res Pract
Guo X, Wang X, Xu C, Wang Y, Li X, Xiong L, Jin H.   +6 more
europepmc   +1 more source

The Need for a Standard Outcome for Clinical Deterioration in Children's Hospitals. [PDF]

Pediatrics, 2023
Galligan MM, Sosa T, Dewan M.
europepmc   +1 more source

Establishment of a coculture system for Porphyromonas gingivalis and head and neck squamous cell carcinoma using spheroid culture and LATS inhibition

FEBS Open Bio, EarlyView.
We established a spheroid coculture system enabling viable Porphyromonas gingivalis–HNSCC interactions under normoxic conditions. Inhibition of LATS1/2 maintains tumor cells in an undifferentiated state, which may promote spheroid growth and create a more permissive environment for bacterial persistence.
Yurika Nakajima, Shogo Okazaki, Muneaki Tamura, Shuichi Sato, Kenichi Imai   +4 more
wiley   +1 more source

Antibiofilm activity of a chionodracine‐derived peptide by NMR‐based metabolomics of cell‐free supernatant of Acinetobacter baumannii clinical strains

FEBS Open Bio, EarlyView.
KHS‐Cnd peptide is able to impair biofilm formation and disaggregate mature biofilms in Acinetobacter baumannii clinical isolates. Differences in extracellular metabolites reflect changes in biofilm metabolism due to KHS‐Cnd treatment. Among the differentially represented extracellular metabolites upon KHS‐Cnd treatment, the significantly altered ...
Fernando Porcelli, Enrico Landi, Francesco Maiurano, Irene Paris, Rosanna Papa, Marco Artini, Laura Selan, Stefano Borocci, Francesco Buonocore, Esther Imperlini   +9 more
wiley   +1 more source

Vital signs as biomarkers of early clinical deterioration in pediatric emergency departments: physiology, interpretation, and innovations: a narrative review. [PDF]

Int J Emerg Med
Alsabri M, Mourid MR, Saleh AR, Oyedele TJ, Ata IM, Darawish SM, Patel A, Rouh FA, Carr LA.   +8 more
europepmc   +1 more source