Results 41 to 50 of about 404,737 (261)

Using clinical simulation to assess a new paediatric ESCALATION system education package: Empirical research mixed methods

Nursing Open
Aim The aim of the study was to assess the suitability of an online education package to prepare health professionals to use a new paediatric early warning system. Design Quasi‐experimental mixed methods using co‐production.
Alannah Cooper, Rebecca Iten, Gavin D. Leslie, David Barrett, Marguerite Lane, Jonathon Mould, Prasanthy Hamsanathan, Scott Stokes, Pania Falconer, Margaret Wood, Samantha Cheesman, Fenella J. Gill   +11 more
doaj   +1 more source

Serological Benefit of SARS‐CoV‐2 Vaccination Relative to Infection in Children With Acute Lymphoblastic Leukemia

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Children with acute lymphoblastic leukemia (ALL) are at risk of severe outcomes from SARS‐CoV‐2 (SCV2). In the post‐pandemic context, where most children have been infected with SCV2, there are limited data on whether vaccination remains beneficial in children with ALL.
Janna R. Shapiro, Freda Qi, Karen Colwill, Alina D. Dorogy, Ying Liu, Michelle Science, Anne‐Claude Gingras, James M. Rini, Sumit Gupta, Sarah Alexander, Shelly Bolotin, Tania H. Watts   +11 more
wiley   +1 more source

Deep Sequencing of FLT3‐ITD Enables Response Evaluation and Post‐Treatment Monitoring in Childhood AML: An Exploratory Study

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background An internal tandem duplication in the gene encoding Fms‐like tyrosine kinase 3 (FLT3‐ITD) is associated with high relapse risk and poor prognosis in acute myeloid leukemia (AML) and plays a crucial role in treatment decisions. Measurable residual disease (MRD) analysis of FLT3‐ITD during and after treatment has shown prognostic ...
Sofie Johansson Alm, Bea Tornberg, Erik Delsing Malmberg, Henrik Hasle, Kristian Løvvik Juul‐Dam, Lars Palmqvist, Borhan R. Saeed, Giti Shah Barkhordar, Anastasia Soboli, Anna Staffas, Jonas Abrahamsson, Linda Fogelstrand   +11 more
wiley   +1 more source

Contactless and continuous monitoring of respiratory rate in a hospital ward: a clinical validation study

Frontiers in Physiology
IntroductionContinuous monitoring of respiratory rate in hospital wards can provide early detection of clinical deterioration, thereby reducing mortality, reducing transfers to intensive care units, and reducing the hospital length of stay.
Ståle Toften, Jonas T. Kjellstadli, Jørn Kværness, Line Pedersen, Line Pedersen, Lars E. Laugsand, Lars E. Laugsand, Ole K. F. Thu, Ole K. F. Thu   +8 more
doaj   +1 more source

Claudin‐6 Protein Expression in Atypical Teratoid/Rhabdoid Tumors Is Strongly Enriched in the Molecular Subgroup AT/RT‐TYR

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Claudin‐6 has emerged as a promising immunotherapeutic target, yet protein‐level data in atypical teratoid/rhabdoid tumors (AT/RTs) have been inconsistent. We analyzed 36 well‐characterized AT/RT samples and found membranous claudin‐6 protein expression in 58% of cases, with striking enrichment in the molecular subgroup AT/RT‐TYR (100%) and ...
Victoria E. Fincke, Christian Thomas, Michael C. Frühwald, Pascal D. Johann, Martin Hasselblatt   +4 more
wiley   +1 more source

Use of National Early Warning Score for observation for increased risk for clinical deterioration during post-ICU care at a surgical ward

Therapeutics and Clinical Risk Management, 2019
Pia Katrin Klepstad,1 Trond Nordseth,2,3 Normunds Sikora,4 Pål Klepstad2,5 1Faculty of Medicine, Riga Stradins University, Riga, Latvia; 2Department of Circulation and Medical Imaging, Faculty of Medicine and Health Sciences, Norwegian University ...
Klepstad PK, Nordseth T, Sikora N, Klepstad P   +3 more
doaj  

Outcomes of Vital Sign Monitoring of an Acute Surgical Cohort With Wearable Sensors and Digital Alerting Systems: A Pragmatically Designed Cohort Study and Propensity-Matched Analysis

Frontiers in Bioengineering and Biotechnology, 2022
Background: The implementation and efficacy of wearable sensors and alerting systems in acute secondary care have been poorly described.Objectives: to pragmatically test one such system and its influence on clinical outcomes in an acute surgical cohort ...
Fahad Mujtaba Iqbal, Meera Joshi, Rosanna Fox, Tonia Koutsoukou, Arti Sharma, Mike Wright, Sadia Khan, Hutan Ashrafian, Ara Darzi   +8 more
doaj   +1 more source

Emapalumab for Immune Effector Cell‐Associated Hemophagocytic Lymphohistiocytosis‐Like Syndrome Following CD19‐Directed CAR‐T in Two Patients With B‐ALL: Clinical and Biomarker Correlates

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Immune effector cell‐associated hemophagocytic lymphohistiocytosis‐like syndrome (IEC‐HS) is a life‐threatening hyperinflammatory toxicity distinct from cytokine release syndrome (CRS) and neurotoxicity following chimeric antigen receptor T‐cell (CAR‐T) therapy. In a single‐institution retrospective cohort of pediatric and young adult patients
Thomas J. Galletta, Jeremy D. Rubinstein, Christopher E. Dandoy, Ruby Khoury, Angela Faulhaber, Christine L. Phillips, Christa Krupski   +6 more
wiley   +1 more source

A Study of NEWS Vital Signs in the Emergency Department for Predicting Short- and Medium-Term Mortality Using Decision Tree Analysis

Applied Sciences
Early detection of clinical deterioration in emergency department (ED) patients is critical for timely interventions. This study evaluated the predictive performance of the National Early Warning Score (NEWS) parameters using machine learning.
Serena Sibilio, Gianni Turcato, Bastiaan Van Grootven, Marta Ziller, Francesco Brigo, Arian Zaboli   +5 more
doaj   +1 more source

The Role of Hematopoietic Cell Transplantation in Ataxia‐Telangiectasia

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Ataxia‐telangiectasia (A‐T) is a DNA repair disorder characterized by neurodegeneration, immunodeficiency, and cancer predisposition. Hematopoietic cell transplantation (HCT) is an established therapy in related disorders such as Fanconi anemia (FA) and Nijmegen breakage syndrome (NBS), but its role in A‐T is unclear.
Laila Alkhouli, Seth Rotz, Masatoshi Takagi, Richa Sharma   +3 more
wiley   +1 more source