Results 61 to 70 of about 404,737 (261)

Prognosis of Long‐Term Continuous Renal Replacement Therapy and the Impact of Combined Continuous Intravenous Sodium Infusion Therapy

Therapeutic Apheresis and Dialysis, EarlyView.
ABSTRACT Introduction Patients requiring long‐term continuous renal replacement therapy (CRRT) generally have poor prognoses. This study evaluated whether adding continuous intravenous sodium infusion (cIVNa) is associated with improved hemodynamics and outcomes in patients undergoing long‐term CRRT for ≥ 7 days.
Akinori Yamaguchi, Atsuyoshi Mita, Kosuke Sonoda, Makoto Harada, Koji Hashimoto, Hiroshi Imamura, Yuji Kamijo   +6 more
wiley   +1 more source

Reciprocal control of viral infection and phosphoinositide dynamics

FEBS Letters, EarlyView.
Phosphoinositides, although scarce, regulate key cellular processes, including membrane dynamics and signaling. Viruses exploit these lipids to support their entry, replication, assembly, and egress. The central role of phosphoinositides in infection highlights phosphoinositide metabolism as a promising antiviral target.
Marie Déborah Bancilhon, Bruno Mesmin
wiley   +1 more source

Postoperative Monitoring for Clinical Deterioration

, 2014
Approximately 40 million surgeries take place annually in the United States, many of them requiring overnight or lengthier postoperative stays from the 5,000 or more hospitals that comprise our acute healthcare system. Throughout the twentieth century patients assumed that being surrounded by well trained nurses and physicians in hospitals guaranteed ...
openaire   +1 more source

Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?

FEBS Letters, EarlyView.
This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes, Guilherme M. Azevedo, Amanda P. Barcellos, Diana Bahia   +3 more
wiley   +1 more source

Predicting Clinical Deteriorations Using Wearable Sensors

, 2018
Introduction Acutely-ill hospitalised patients are at risk of clinical deteriorations such as cardiac arrest, admission to intensive care, or unexpected death. Currently, patients are manually assessed every 4-6 hours to determine the likelihood of subsequent deterioration.
Charlton, Peter H, Bonnici, Timothy, Tarassenko, Lionel, Watkinson, Peter J, Clifton, David A, Beale, Richard, Alastruey, Jordi   +6 more
openaire   +4 more sources

National Early Warning Score 2: transcultural adaptation to Brazilian Portuguese

Revista Gaúcha de Enfermagem, 2020
Objective: Cross-cultural adaptation of the National Early Warning Score 2 to Brazilian Portuguese. Methods: A methodological study of a cross-cultural adaptation of a scale, based on the Beaton et al.
Ana Paula Amestoy de Oliveira, Janete de Souza Urbanetto, Rita Catalina Aquino Caregnato   +2 more
doaj   +2 more sources

Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation

FEBS Letters, EarlyView.
Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe, Tanmay Kumar Mohanty, Rashna Bhandari, Dorothea Fiedler   +3 more
wiley   +1 more source

Progression of GBA1 severe and risk variants: a longitudinal mixed model analysis

Frontiers in Aging Neuroscience
IntroductionAn association between severe GBA1 variants and the progression of non-motor symptoms in PD has been reported, but the role of Parkinson’s-risk (PD-risk) GBA1 variants is less clear.MethodsWe assessed symptom progression in individuals with ...
Anne-Marie Hanff, Anne-Marie Hanff, Anne-Marie Hanff, Anne-Marie Hanff, Christopher McCrum, Armin Rauschenberger, Sinthuja Pachchek, Gloria A. Aguayo, Claire Pauly, Claire Pauly, Claire Pauly, Sonja R. Jónsdóttir, Sonja R. Jónsdóttir, Sonja R. Jónsdóttir, Olena Tsurkalenko, Olena Tsurkalenko, Olena Tsurkalenko, Olena Tsurkalenko, Laure Pauly, Laure Pauly, Laure Pauly, Zied Landoulsi, Zied Landoulsi, Anja K. Leist, Patrick May, Maurice P. Zeegers, Rejko Krüger, Rejko Krüger, Rejko Krüger   +28 more
doaj   +1 more source

Structural instability impairs function of the UDP‐xylose synthase 1 Ile181Asn variant associated with short‐stature genetic syndrome in humans

FEBS Letters, EarlyView.
The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li, Pedro A. Sánchez‐Murcia, Bernd Nidetzky   +2 more
wiley   +1 more source

Continuous Vital Signs Monitoring with a Wireless and Wearable Earsensor in Surgical Patients: A Clinical Validation Study

Sensors
(1) Background: Evidence on the clinical accuracy of wireless photoplethysmography (PPG)-based vital sign monitoring is limited. This study evaluated the accuracy, technical performance, and patient comfort of a novel PPG-based earsensor for measuring ...
Patrick van den Berge, Kim van Loon, Lianne Zevenbergen, Pascalle A. van den Heuvel, Martine J. M. Breteler   +4 more
doaj   +1 more source