Results 71 to 80 of about 404,737 (261)

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

FEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

Unobtrusive Monitoring of Clinical Deterioration in Smart Homes

Clinical deterioration (CD) is the physiological decompensation that incurs care escalation, protracted hospital stays, or even death. The early warning score (EWS) calculates the occurrence of CD based on five vital signs. However, there are limited reports regarding EWS monitoring in smart home settings.
Sharareh Rostam Niakan Kalhori, Mozhgan Tanhapour, Thomas M. Deserno   +2 more
openaire   +2 more sources

Transferrin receptor 1‐mediated iron uptake supports thermogenic activation in human cervical‐derived adipocytes

FEBS Letters, EarlyView.
In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai, Mizuki Seo, Gyath Karadsheh, Fachrur Rizal Mahendra, Máté Á Demény, Ferenc Győry, János András Mótyán, László Fésüs, Endre Kristóf, Rini Arianti   +9 more
wiley   +1 more source

Implementation of an AI-Based Clinical Decision Support System Predicting In-Hospital Cardiac Arrest in General Wards: A Multicenter Staggered-Implementation Study in Secondary Hospitals in Korea

Diagnostics
Background/Objectives: In-hospital cardiac arrest (IHCA) remains a devastating event associated with high morbidity and mortality among general ward patients.
Minjeong Kim, Dongjoon Yoo, Eunbi Noh, Yongwook Jeong, Minsoo Kim, Kyung-Jae Cho, Mincheol Kim, You Dong Sohn, Gyu Chong Cho   +8 more
doaj   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Improvement in Functional Outcome from 6 to 12 Months After Moderate and Severe Traumatic Brain Injury Is Frequent, But May Not Be Detected With the Glasgow Outcome Scale Extended

Neurotrauma Reports
The aims of this study were (1) to report outcome and change in outcome in patients with moderate and severe traumatic brain injury (mo/sTBI) between 6 and 12 months post-injury as measured by the Glasgow Outcome Scale Extended (GOSE), (2) to explore if ...
Rabea Iris Pantelatos, Jonas Stenberg, Turid Follestad, Oddrun Sandr?d, Cathrine Elisabeth Einarsen, Anne Vik, Toril Skandsen   +6 more
doaj   +3 more sources

Predicting Deterioration in Patients With Normotensive Acute Pulmonary Embolism Using Clinical‐Imaging Features: A Multicenter Prospective Cohort Study

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease
Background Prioritization of management strategies in patients with normotensive acute pulmonary embolism is based on the identification of individuals at risk for early deterioration.
Yizhuo Gao, Shibo Wei, Yuchen Liu, Zhenglun Yu, Shanshan Zhan, Binze Yang, Chuanxin Qi, Shougang Qi, Minggang Wang, Dong Jia   +9 more
doaj   +1 more source

Valosin‐containing protein counteracts ATP‐driven dissolution of FUS condensates through its ATPase activity in vitro

FEBS Letters, EarlyView.
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura, Shin‐ichi Tate, Kyota Yasuda   +2 more
wiley   +1 more source

Predictors of in-hospital mortality in patients requiring transfer to the medical intensive care unit

Journal of the Pakistan Medical Association
Objective: To identify the factors associated with higher odds of in-hospital mortality among inpatients requiring transfer to the medical intensive care unit.
Huzefa Jibril, Muhammad Azhar, Ainan Arshad, Safia Awan, Syed Ahsan Ali, Muhammed Tariq   +5 more
doaj   +1 more source

Linking neurogenesis, oligodendrogenesis, and myelination defects to neurodevelopmental disruption in primary mitochondrial disorders

FEBS Letters, EarlyView.
Mitochondrial remodeling shapes neural and glial lineage progression by matching metabolic supply with demand. Elevated OXPHOS supports differentiation and myelin formation, while myelin compaction lowers mitochondrial dependence, revealing mitochondria as key drivers of developmental energy adaptation.
Sahitya Ranjan Biswas, Porter L. Tomsick, Alicia M. Pickrell, Paul D. Morton   +3 more
wiley   +1 more source