Results 91 to 100 of about 5,531,484 (250)

Inflection points in hearing deterioration: clinical characteristics of NIHL from steady-state noise exposure [PDF]

Objectives To explore the clinical characteristics of noise-induced hearing loss (NIHL) caused by long-term exposure to steady-state noise and find a possible inflection point time leading to hearing deterioration.
Liu, Gang, Xiaoli Zhang, Wu, Wei, Zhang, Xiaoli, Boya Fan, Wang, Gang, Gang Liu, Yulin Kang, Kang, Yulin, Fan, Boya, Wei Wu, Gang Wang, Han Wang, Wang, Han   +13 more
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Recognising and responding to in-hospital clinical deterioration: An integrative review of interprofessional practice issues [PDF]

, 2017
Aims and Objectives: To identify, appraise and synthesise current evidence regarding organisation-wide interprofessional practice issues that facilitate or inhibit effective recognition and response to clinical deterioration, using a theoretical rapid ...
Elliott, Doug, Debra Jackson, Emily Allen, Jackson, Debra, Jackson, D, Allen, E., Jackson, D., Elliott, D, Allen, E, Doug Elliott, Elliott, D., Allen, Emily   +11 more
core   +1 more source

Association between packed red blood cell transfusion and clinical deterioration in neonatal necrotizing enterocolitis: a systematic review and meta-analysis

Annals of Medicine
Background No systematic review has evaluated the existing evidence regarding the association between packed red blood cell (pRBC) transfusion and clinical worsening of necrotizing enterocolitis (NEC) in neonates. This systematic review and meta-analysis
Jinglan Huang, Qian Gao, Ziqing Xu, Hua Wang   +3 more
doaj   +1 more source

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

Progression of GBA1 severe and risk variants: a longitudinal mixed model analysis

Frontiers in Aging Neuroscience
IntroductionAn association between severe GBA1 variants and the progression of non-motor symptoms in PD has been reported, but the role of Parkinson’s-risk (PD-risk) GBA1 variants is less clear.MethodsWe assessed symptom progression in individuals with ...
Anne-Marie Hanff, Anne-Marie Hanff, Anne-Marie Hanff, Anne-Marie Hanff, Christopher McCrum, Armin Rauschenberger, Sinthuja Pachchek, Gloria A. Aguayo, Claire Pauly, Claire Pauly, Claire Pauly, Sonja R. Jónsdóttir, Sonja R. Jónsdóttir, Sonja R. Jónsdóttir, Olena Tsurkalenko, Olena Tsurkalenko, Olena Tsurkalenko, Olena Tsurkalenko, Laure Pauly, Laure Pauly, Laure Pauly, Zied Landoulsi, Zied Landoulsi, Anja K. Leist, Patrick May, Maurice P. Zeegers, Rejko Krüger, Rejko Krüger, Rejko Krüger   +28 more
doaj   +1 more source

Epigenetic reprogramming of lineage switching in cancer

FEBS Letters, EarlyView.
Cancer cells rarely commit to a single identity. Epigenetic mechanisms and tumor microenvironment cues push epithelial cells toward flexible, hybrid states that can shift into mesenchymal, neuroendocrine, or stem‐like fates, driving metastasis, drug resistance, and tumor heterogeneity. Targeting the epigenetic regulators behind these transitions, using
Ezgi Boyvatlı, Burcu Akman, Ezgi Bağırsakçı, Nese Atabey, Serap Erkek‐Ozhan   +4 more
wiley   +1 more source

Prevalence of clinical deterioration in the pre‐hospital setting

Emergency Medicine Australasia
AbstractObjectiveImproved understanding of the deteriorating patient in the pre‐hospital setting may result in earlier recognition and response. Considering the effects of undetected deterioration are profound, it is fundamental to report the prevalence of pre‐hospital clinical deterioration to advance our understanding.
Emma Bourke‐Matas, Tan Doan, Kelly‐Ann Bowles, Emma Bosley   +3 more
openaire   +2 more sources

Autophagy and mitophagy in pancreatic β‐cell homeostasis and their involvement in diabetes pathophysiology

FEBS Letters, EarlyView.
This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee, Mingming Tong, Anna L. Gloyn   +2 more
wiley   +1 more source

Partial depletion of plasminogen activator inhibitor‐1 decreases subcutaneous fat cell hypertrophy and liver cholesterol in high‐fat‐fed female mice

FEBS Letters, EarlyView.
Obesity raises blood levels of PAI‐1, a protein linked to metabolic dysfunction‐associated steatotic liver disease in people with obesity. In female mice fed a high‐fat diet, partially lowering PAI‐1 led to smaller subcutaneous fat cells and lower liver cholesterol, without changing body weight or insulin sensitivity.
Claudia E. Ramirez Bustamante, Robert Sharp, Pradip K. Saha, Elizabeth S. Anaya, Elizabeth L. Lieu, Evelyn L. de Groot, Pooja Patel, Mi Jeong Heo, Aaron R. Cox, Kang Ho Kim, Sean M. Hartig   +10 more
wiley   +1 more source

Determine Initial Cause for Current Premature Portland Cement Concrete Pavement Deterioration Final Report; TR-406, 2000 [PDF]

, 2000
A detailed investigation has been conducted on core samples taken from 17 portland cement concrete pavements located in Iowa. The goal of the investigation was to help to clarify the root cause of the premature deterioration problem that has become ...

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