Results 111 to 120 of about 5,531,484 (250)

Leucine‐rich glioma inactivated 1 (LGI1) is a ganglioside‐binding protein

FEBS Letters, EarlyView.
Neuronal hyperexcitability associated with a decrease/absence of the extracellular protein LGI1 has been suggested to be primarily due to the downregulation of Kv1 channel expression. The molecular mechanisms underlying this decrease have not yet been elucidated.
Kévin Debreux, Christian Lévêque, Fodil Azzaz, Marion Sangiardi, Sarosh R Irani, Michael Seagar, Jacques Fantini, Oussama El Far   +7 more
wiley   +1 more source

Clinical Deterioration Among Emergency Department Boarders: From Hallway Monitoring to a Structured Rescue System

Panorama of Emergency Medicine
Background: Emergency department (ED) boarding places admitted patients in an environment designed for rapid episodic assessment rather than longitudinal inpatient surveillance.
Mohammed Alkhanafsa, Jamil Wafi, Soud Deek   +2 more
doaj   +1 more source

A context‐dependent modulatory role for eIF6 in acquired resistance to vemurafenib in melanoma

FEBS Letters, EarlyView.
Acquired resistance to vemurafenib upregulates the translation factor eIF6 in melanoma cells. Silencing eIF6 in resistant cells reduces proliferation and partially restores drug sensitivity, whereas its overexpression increases sensitivity across melanoma lines regardless of BRAF status, via modulation of mTOR, S6K, and MAPK signaling.
George Kyriakopoulos, Antonia Petropoulou, Alexandra Anastogianni, Angelina Bania, Vassilis Stamatakis, Argyris Alexiou, Chi‐Ping Day, Glenn Merlino, Katerina Grafanaki, Constantinos Stathopoulos   +9 more
wiley   +1 more source

Host genetics predict clinical deterioration in HCV-related cirrhosis [PDF]

, 2014
Single nucleotide polymorphisms (SNPs) in the epidermal growth factor (EGF, rs4444903), patatin-like phospholipase domain-containing protein 3 (PNPLA3, rs738409) genes, and near the interleukin-28B (IL28B, rs12979860) gene are linked to treatment ...
Johnson, K. (K) B. (B), King, L. (L) Y. (Y), Fuchs, B. (B) C. (C), Chan, A. (A) T. (T), Corey, K. (K) E. (E), Zheng, H. (H), Hoshida, Y. (Y), Wei, L. (L), Tanabe, K. (K) K. (K), Ufere, N. (N), Gudewicz, T. (T), Baumert, T. (Thomas) F. (F), Chung, R. (R) T. (T), Ajayi, T. (T)   +13 more
core   +1 more source

Predicting Deterioration in Patients With Normotensive Acute Pulmonary Embolism Using Clinical‐Imaging Features: A Multicenter Prospective Cohort Study

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease
Background Prioritization of management strategies in patients with normotensive acute pulmonary embolism is based on the identification of individuals at risk for early deterioration.
Yizhuo Gao, Shibo Wei, Yuchen Liu, Zhenglun Yu, Shanshan Zhan, Binze Yang, Chuanxin Qi, Shougang Qi, Minggang Wang, Dong Jia   +9 more
doaj   +1 more source

Metastatic niche shaped by host factors influences disseminated cancer cell fate

FEBS Letters, EarlyView.
Metastasis is shaped not only by cancer cells but also by the environments they encounter. This review explores how factors such as aging, diet, the microbiome, lifestyle, and environmental exposures remodel organ‐specific niches in the lung, liver, bone, and brain, influencing where metastatic cells survive, remain dormant, or grow, and ultimately ...
Gwennan Delyth Ward, Álvaro Ruiz‐Tabas, Patricia Altea‐Manzano   +2 more
wiley   +1 more source

Night Physician–Nurse Collaboration: Developing the Scale of Physicians’ Difficulties and Exploring Related Factors in Acute Care Hospitals

Journal of Multidisciplinary Healthcare
Soichiro Hotta,1 Kaoru Ashida,2 Makoto Tanaka1 1Department of Adult Health Nursing, Graduate School of Health Care Sciences, Tokyo Medical and Dental University, Bunkyo-ku, Tokyo, Japan; 2Department of Nursing, College of Nursing, Kanto Gakuin University,
Hotta S, Ashida K, Tanaka M
doaj  

Predictors of in-hospital mortality in patients requiring transfer to the medical intensive care unit

Journal of the Pakistan Medical Association
Objective: To identify the factors associated with higher odds of in-hospital mortality among inpatients requiring transfer to the medical intensive care unit.
Huzefa Jibril, Muhammad Azhar, Ainan Arshad, Safia Awan, Syed Ahsan Ali, Muhammed Tariq   +5 more
doaj   +1 more source

The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers

Molecular Oncology, EarlyView.
The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce, Simone Bini, Marialuisa Sponziello, Giorgio Grani, Giulia Fiscon, Paola Paci, Lorenzo Farina, Rosa Falcone, Valentina Maggisano, Sebastiano Filetti, Cosimo Durante, Antonella Verrienti   +11 more
wiley   +1 more source

Optimal Inventory Policies for Weibull Deterioration under Trade Credit in Declining Market [PDF]

The aim of this study is to develop mathematical model for Weibull deterioration of items in inventory in declining market when the supplier offers his retailers a credit period to settle the accounts against the dues.
Nidhi Raykundaliya, Nita H. Shah
core