Results 131 to 140 of about 404,737 (261)

Development and validation of three risk prediction models for clinical deterioration of patients after craniotomy: a retrospective cohort study in China. [PDF]

BMJ Open
Xu L, Luo Z, Xu H, Tang Y, Wang L, Peng L.   +5 more
europepmc   +1 more source

Derivation and characterization of retinal pigment epithelium from urine‐derived iPSCs

FEBS Open Bio, EarlyView.
Age‐related macular degeneration causes vision loss via RPE dysfunction and loss. Traditional iPSC therapies rely on invasive biopsies, limiting scalability. Here, we utilize urine‐derived stem cells as an accessible source to generate u‐iPSCs, successfully differentiated into pigmented RPE. This “Urine‐to‐Retina” platform provides a promising path for
Daniella Beiner, Hainan Zhu, Carol Christine Bosholm, Heuy‐Ching Wang, Tracy Criswell, Anthony Atala, Jian‐Xing Ma, Yuanyuan Zhang   +7 more
wiley   +1 more source

Treatment Recommendations for Clinical Deterioration on the Wards: Development and Validation of Machine Learning Models. [PDF]

JMIR AI
Pulick E, Carey KA, Qyli T, Oguss MK, Picart JK, Penumalee L, Nezirova LK, Tully ST, Gilbert ER, Shah NS, Ravichandran U, Afshar M, Edelson DP, Mintz Y, Churpek MM.   +14 more
europepmc   +1 more source

Pharmacological inhibition of the PERK pathway modulates hepatocellular carcinoma growth and immune signaling

FEBS Open Bio, EarlyView.
Pharmacological inhibition of PERK in a DEN‐induced mouse model of liver cancer does not reduce tumor burden but alters cellular stress signaling. Despite blocking PERK activity, downstream stress responses, including CHOP expression, remain active, suggesting compensatory mechanisms within the unfolded protein response that may influence tumor ...
Ada Lerma‐Clavero, Maria Kopsida, Nathalie Arendt, Hans Lennernäs, Markus Sjöblom, Femke Heindryckx   +5 more
wiley   +1 more source

Early‐life high‐fat diet exposure increases Achilles tendon stiffness and induces transcriptomic alterations

FEBS Open Bio, EarlyView.
Early‐life exposure to a high‐fat diet altered intact Achilles tendons in rat offspring, making them thinner, stiffer, and molecularly distinct even without injury. These findings suggest that developmental high‐fat diet exposure may impair tendon quality and increase susceptibility to mechanical overload or tendon injury later in life.
Heyong Yin, Ziyang Yuan, Wenli Jiang, Ai Guo   +3 more
wiley   +1 more source

Contrast Reflux Into IVC in Acute Pulmonary Embolism Predicts Clinical Deterioration Risk. [PDF]

Pulm Circ
Leverone NA, Singer AG, Lopez AA, Ellberg C, Henry PJ, Kabadi AA, Self AA, Leverone DM, Yen A, Hahn L, Karunamuni J, Weihe E, Yang JZ, McGuire WC, Papamatheakis DG, Morris TA, Fernandes TM.   +16 more
europepmc   +1 more source

The C‐terminal region of KIF26B is indispensable for nephron progenitor condensation and kidney formation in mice

FEBS Open Bio, EarlyView.
KIF26B plays an important role in kidney development. We engineered mice lacking the C‐terminal region of KIF26B and found severe kidney defects, including bilateral renal agenesis, similar to full Kif26b knockout mice. The mutation disrupted nephron progenitor condensation and reduced Gdnf‐Wnt11 signaling, showing that the KIF26B C‐terminal region is ...
Yuta Yamamura, Kengo Furuichi, Hiromitsu Akamatsu, Naoki Yamamoto, Sako Keisuke, Akihiko Koshino, Taichiro Minami, Megumi Oshima, Akinori Hara, Norihiko Sakai, Miho Shimizu, Kenta Takahashi, Minako Yamamura, Shin‐ichi Horike, Takiko Daikoku, Kenichi Harada, Yohei Shinmyo, Hiroshi Kawasaki, Takashi Wada, Yasunori Iwata   +19 more
wiley   +1 more source

Intracranial haemorrhage without early clinical deterioration after mechanical thrombectomy: rethinking the "asymptomatic" label. [PDF]

Eur Stroke J
Riegler C, Nolte CH, von Rennenberg R, Bollweg K, Hahn M, Uphaus T, Alegiani A, Illies T, Wischmann J, Kellert L, Bernkopf K, Wunderlich S, Hennersdorf F, Poli S, Mann L, Keil F, Jamous A, Ernst MS, Bürkle F, Wiesmann M, Akkurt B, Faizy T, Audebert HJ, Wattjes MP, Siebert E, Nawabi J.   +25 more
europepmc   +1 more source

Time‐restricted feeding prior to Mycobacterium tuberculosis infection reduces tissue CD4+ T cells with limited impact on bacterial clearance

FEBS Open Bio, EarlyView.
Time‐restricted feeding (TRF) in mice increased liver fatty acid oxidation and decreased fatty acid biosynthesis. These alterations persisted when TRF was discontinued and the host was infected with Mycobacterium tuberculosis. Pre‐exposure to TRF did not alter tissue (lung and spleen) mycobacterial burden but significantly reduced CD3+ T cells in lungs
Ashish Gupta, Nidhi Yadav, Subhasmita Das, R. Rajendra Kumar Reddy, Nupur Sharma, Amol Ratnakar Suryawanshi, Jaswinder Singh Maras, Ranjan Kumar Nanda   +7 more
wiley   +1 more source

Assessing Clinical Deterioration in Children With Dark-Coloured Skin: A Scoping Review. [PDF]

J Clin Nurs
Kelly C, Leslie GD, Laird P, Stokes S, Gill FJ.   +4 more
europepmc   +1 more source